FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179635229> ?p ?o ?g. }

• W3179635229 endingPage "3272" @default.
• W3179635229 startingPage "3260" @default.
• W3179635229 abstract "Cerebrovascular reactivity (CVR) deficits in adolescents with concussion may persist after resolution of neurological symptoms. Whether or not CVR deficits predict long term neurological function is unknown. We used adolescent mice closed head injury (CHI) models (54 g, 107 cm or 117 cm drop height), followed by blood oxygenation level dependent (BOLD)-functional MRI with CO 2 challenge to assess CVR and brain connectivity. At one week, 3HD 107 cm mice showed delayed BOLD responses (p = 0.0074), normal striatal connectivity , and an impaired respiratory rate response to CO 2 challenge (p = 0.0061 in ΔRmax). The 107 cm group developed rotarod deficits at 6 months (p = 0.02) and altered post-CO 2 brain connectivity (3-fold increase in striatum to motor cortex correlation coefficient) by one year, but resolved their CVR and respiratory rate impairments, and did not develop cognitive or circadian activity deficits. In contrast, the 117 cm group had persistent CVR (delay time: p = 0.016; washout time: p = 0.039) and circadian activity deficits (free-running period: 23.7 hr in sham vs 23.9 hr in 3HD; amplitude: 0.15 in sham vs 0.2 in 3HD; peak activity: 18 in sham vs 21 in 3HD) at one year. Persistent CVR deficits after concussion may portend long-term neurological dysfunction. Further studies are warranted to determine the utility of CVR to predict chronic neurological outcome after mild traumatic brain injury." @default.
• W3179635229 created "2021-07-19" @default.
• W3179635229 creator A5013885426 @default.
• W3179635229 creator A5030278996 @default.
• W3179635229 creator A5030374908 @default.
• W3179635229 creator A5033476536 @default.
• W3179635229 creator A5048404758 @default.
• W3179635229 creator A5049338127 @default.
• W3179635229 creator A5060453417 @default.
• W3179635229 creator A5060893966 @default.
• W3179635229 creator A5068685410 @default.
• W3179635229 creator A5072836685 @default.
• W3179635229 creator A5078730545 @default.
• W3179635229 creator A5083117986 @default.
• W3179635229 date "2021-07-06" @default.
• W3179635229 modified "2023-09-30" @default.
• W3179635229 title "Persistent CO₂ reactivity deficits are associated with neurological dysfunction up to one year after repetitive mild closed head injury in adolescent mice" @default.
• W3179635229 cites W1542758806 @default.
• W3179635229 cites W1561556868 @default.
• W3179635229 cites W1563954785 @default.
• W3179635229 cites W176552710 @default.
• W3179635229 cites W1940088424 @default.
• W3179635229 cites W1965498307 @default.
• W3179635229 cites W1971432878 @default.
• W3179635229 cites W1977061412 @default.
• W3179635229 cites W1984305500 @default.
• W3179635229 cites W2000180742 @default.
• W3179635229 cites W2003695051 @default.
• W3179635229 cites W2009898156 @default.
• W3179635229 cites W2018299673 @default.
• W3179635229 cites W2021706041 @default.
• W3179635229 cites W2033958089 @default.
• W3179635229 cites W2034579949 @default.
• W3179635229 cites W2050096761 @default.
• W3179635229 cites W2058509758 @default.
• W3179635229 cites W2059878187 @default.
• W3179635229 cites W2062769941 @default.
• W3179635229 cites W2064338536 @default.
• W3179635229 cites W2065403797 @default.
• W3179635229 cites W2068351868 @default.
• W3179635229 cites W2076256914 @default.
• W3179635229 cites W2078803304 @default.
• W3179635229 cites W2079776123 @default.
• W3179635229 cites W2104591424 @default.
• W3179635229 cites W2131375848 @default.
• W3179635229 cites W2141460918 @default.
• W3179635229 cites W2149159573 @default.
• W3179635229 cites W2151975160 @default.
• W3179635229 cites W2160025504 @default.
• W3179635229 cites W2165702652 @default.
• W3179635229 cites W2173135046 @default.
• W3179635229 cites W2198344835 @default.
• W3179635229 cites W2199850701 @default.
• W3179635229 cites W2215310868 @default.
• W3179635229 cites W2278483058 @default.
• W3179635229 cites W2299094852 @default.
• W3179635229 cites W2342996989 @default.
• W3179635229 cites W2464606638 @default.
• W3179635229 cites W2470893332 @default.
• W3179635229 cites W2482417927 @default.
• W3179635229 cites W2563562100 @default.
• W3179635229 cites W2585312316 @default.
• W3179635229 cites W2595085771 @default.
• W3179635229 cites W2616216465 @default.
• W3179635229 cites W2736091234 @default.
• W3179635229 cites W2754904662 @default.
• W3179635229 cites W2766754126 @default.
• W3179635229 cites W2766792024 @default.
• W3179635229 cites W2770162116 @default.
• W3179635229 cites W2793182394 @default.
• W3179635229 cites W2802445858 @default.
• W3179635229 cites W2884980874 @default.
• W3179635229 cites W2885985659 @default.
• W3179635229 cites W2886441802 @default.
• W3179635229 cites W2901295066 @default.
• W3179635229 cites W2980770587 @default.
• W3179635229 cites W2982099630 @default.
• W3179635229 cites W2984937892 @default.
• W3179635229 cites W3000121803 @default.
• W3179635229 cites W3017141168 @default.
• W3179635229 cites W3029190726 @default.
• W3179635229 cites W3032857192 @default.
• W3179635229 cites W3032953656 @default.
• W3179635229 cites W3112280796 @default.
• W3179635229 cites W338840253 @default.
• W3179635229 doi "https://doi.org/10.1177/0271678x211021771" @default.
• W3179635229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34229511" @default.
• W3179635229 hasPublicationYear "2021" @default.
• W3179635229 type Work @default.
• W3179635229 sameAs 3179635229 @default.
• W3179635229 citedByCount "4" @default.
• W3179635229 countsByYear W31796352292022 @default.
• W3179635229 countsByYear W31796352292023 @default.
• W3179635229 crossrefType "journal-article" @default.
• W3179635229 hasAuthorship W3179635229A5013885426 @default.
• W3179635229 hasAuthorship W3179635229A5030278996 @default.
• W3179635229 hasAuthorship W3179635229A5030374908 @default.
• W3179635229 hasAuthorship W3179635229A5033476536 @default.

• next