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• W3179645531 startingPage "4132" @default.
• W3179645531 abstract "This review is dedicated to Professor William A. Denny's discovery of XR5944 (also known as MLN944). XR5944 is a DNA-targeted agent with exceptionally potent antitumor activity and a novel DNA binding mode, bis-intercalation and major groove binding, as well as a novel mechanism of action, transcription inhibition. This novel anticancer compound represents a remarkable accomplishment resulting from two decades of drug discovery by Professor Denny and coworkers. Here, we review our work on the structural study of the DNA binding mode of XR5944 and mechanistic study of XR5944 action." @default.
• W3179645531 created "2021-07-19" @default.
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• W3179645531 date "2021-07-07" @default.
• W3179645531 modified "2023-10-15" @default.
• W3179645531 title "Novel DNA Bis-Intercalator XR5944 as a Potent Anticancer Drug—Design and Mechanism of Action" @default.
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• W3179645531 doi "https://doi.org/10.3390/molecules26144132" @default.
• W3179645531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8304338" @default.
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• W3179645531 hasPublicationYear "2021" @default.
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