FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179689858> ?p ?o ?g. }

• W3179689858 endingPage "4" @default.
• W3179689858 startingPage "4" @default.
• W3179689858 abstract "Abstract:In 2018 newly diagnosed urothelial carcinoma (UC) in Russia were registered in 14,446 cases, including 26% pts in stage III-IV. Thus, for every fourth Russian, UC is first detected in a neglected stage. Due to the Guidelines EAU-2017, cystectomy or alternative therapy with bladder preservation used in the treatment of such patients. Chemotherapy in UC pts (M-VAC, GC and other’s) is accompanied with side effects (myelosuppression, dyspepsia, neuroplegia, etc.) that reduce the patient's QoL and, thus, the effectiveness of therapy.PURPOSE.  To evaluate the effectiveness of regional (i/arterial) ChTer based on platinum drugs in patients with locally advanced UC.MATERIALS AND METHODS. We evaluated the results of regional ChTer in 36 patients with UC in stages T3a-4?N0-1M0G2-3 (8 women, 28 males in median age 65,4±4,2 y.o.) in 1998- 2003 ??. Earlier 21 pts received organ-preserving treatment (TURB + neoadjuvant / adjuvant ChTer), with a short clinical effect. All the patients after the catheterization and angiography of the uroperitoneal arteries received courses (from 6 to 36, median 18) of the regional ChTer (cisplatin, 50 mg / m² and adriablastin, 20 mg / m²) and metostrexate (20 mg / m²) + vinblastine (0, 7 mg / m²) intravenously, by the standard MVAC courses. After finishing of ChTer, the main group of pts was observed during 12-60 months (average 28 months) and over the next 10 years they were studied for their overall survival by a prospective study method.RESULTS. Long-term use of regional ChTer with standard three-week interruptions contributed to partial and complete tumor response in 22 (61.1%) cases. During 24 months after ChTer there were no signs of tumor growth in the bladders of 13 (26.9%) pts. The effect of the treatment was determined by Grade, tumor Stage, the presence of N+ and the previous oncological anamnesis. In 6 (16.7%) cases, with beam and endoscopic confirmation of the tumor progression, we performed salvage cystectomies. Due to the histological report, in 2 bladders were not any tumor cells, which were regarded as a medicinal pathomorphosis.After 12 months after treatment (16 ChTer courses), 2 patients refused to follow up due to the increase of chronic renal failure: ureterohydronephrosis-II, which required palliative nephrostomy. In first 5 years of follow-up, 10 (27.7%) pts died, among them 6 – with tumor progression. The general toxicity was manifested as moderate myelosuppression (G-I, -II neutropenia and G-II thrombocytopenia). The five-year overall survival (OS) rate was 72.3%, which was consistent with the indicator obtained by foreign researchers. The OS was determined by the tumor Stage of the, the Age and severity of the Concomitant pathology, and the presence of N+. According to results of follow-up, 9 (25.0%) pts survived 10 years with a functioning bladder. The initial stage of UC in 5 cases was pT3aN0M0G2, in 2 - pT3aN0M0G3, in 1 case – pT3bN1M0G2 and 1 – pT4aN0M0G2. At the beginning of the study, all surviving patients were younger than 65.CONCLUSIONS:  Regional Chemotherapy was effective in more than 61.1% of UC pT3a-4?N0-1M0G2-3 (complete / partial remission, tumor stabilization). Minimization of side effects was achieved due to selective intra-arterial administration of the drug to the tumor, with a decrease of the medication dose. The life expectancy in 25.0% cases exceeded ten years, which is ahead of the average for pts with locally advanced UC and allows us to confidently talk about the need for further research in this direction." @default.
• W3179689858 created "2021-07-19" @default.
• W3179689858 creator A5059392415 @default.
• W3179689858 date "2021-01-01" @default.
• W3179689858 modified "2023-09-24" @default.
• W3179689858 title "Results of Organ-Sparring Treatment of Muscle-Invasive Urothelial Carcinoma" @default.
• W3179689858 hasPublicationYear "2021" @default.
• W3179689858 type Work @default.
• W3179689858 sameAs 3179689858 @default.
• W3179689858 citedByCount "0" @default.
• W3179689858 crossrefType "journal-article" @default.
• W3179689858 hasAuthorship W3179689858A5059392415 @default.
• W3179689858 hasConcept C121608353 @default.
• W3179689858 hasConcept C126322002 @default.
• W3179689858 hasConcept C126894567 @default.
• W3179689858 hasConcept C141071460 @default.
• W3179689858 hasConcept C146357865 @default.
• W3179689858 hasConcept C151730666 @default.
• W3179689858 hasConcept C2775910329 @default.
• W3179689858 hasConcept C2776694085 @default.
• W3179689858 hasConcept C2777132456 @default.
• W3179689858 hasConcept C2778239845 @default.
• W3179689858 hasConcept C2780352672 @default.
• W3179689858 hasConcept C3019882237 @default.
• W3179689858 hasConcept C71924100 @default.
• W3179689858 hasConcept C86803240 @default.
• W3179689858 hasConceptScore W3179689858C121608353 @default.
• W3179689858 hasConceptScore W3179689858C126322002 @default.
• W3179689858 hasConceptScore W3179689858C126894567 @default.
• W3179689858 hasConceptScore W3179689858C141071460 @default.
• W3179689858 hasConceptScore W3179689858C146357865 @default.
• W3179689858 hasConceptScore W3179689858C151730666 @default.
• W3179689858 hasConceptScore W3179689858C2775910329 @default.
• W3179689858 hasConceptScore W3179689858C2776694085 @default.
• W3179689858 hasConceptScore W3179689858C2777132456 @default.
• W3179689858 hasConceptScore W3179689858C2778239845 @default.
• W3179689858 hasConceptScore W3179689858C2780352672 @default.
• W3179689858 hasConceptScore W3179689858C3019882237 @default.
• W3179689858 hasConceptScore W3179689858C71924100 @default.
• W3179689858 hasConceptScore W3179689858C86803240 @default.
• W3179689858 hasLocation W31796898581 @default.
• W3179689858 hasOpenAccess W3179689858 @default.
• W3179689858 hasPrimaryLocation W31796898581 @default.
• W3179689858 hasRelatedWork W113979827 @default.
• W3179689858 hasRelatedWork W1846302749 @default.
• W3179689858 hasRelatedWork W1974356997 @default.
• W3179689858 hasRelatedWork W2035388912 @default.
• W3179689858 hasRelatedWork W2066875518 @default.
• W3179689858 hasRelatedWork W2151384619 @default.
• W3179689858 hasRelatedWork W2156811053 @default.
• W3179689858 hasRelatedWork W2172534426 @default.
• W3179689858 hasRelatedWork W2221936497 @default.
• W3179689858 hasRelatedWork W2401002890 @default.
• W3179689858 hasRelatedWork W2417318446 @default.
• W3179689858 hasRelatedWork W28087387 @default.
• W3179689858 hasRelatedWork W2999041143 @default.
• W3179689858 hasRelatedWork W3016744253 @default.
• W3179689858 hasRelatedWork W3029255199 @default.
• W3179689858 hasRelatedWork W3029662101 @default.
• W3179689858 hasRelatedWork W3031190030 @default.
• W3179689858 hasRelatedWork W3097818331 @default.
• W3179689858 hasRelatedWork W585349003 @default.
• W3179689858 hasRelatedWork W87095225 @default.
• W3179689858 isParatext "false" @default.
• W3179689858 isRetracted "false" @default.
• W3179689858 magId "3179689858" @default.
• W3179689858 workType "article" @default.