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- W3179721071 abstract "Liver cancer is still a horrible threat to people’s health worldwide. Herein, we aimed to explore the mechanism underlying microRNA (miR)-64’s role in liver cancer progression to provide novel insight into therapy. Expression of miR-64 in liver cancer cells was determined by RT-qPCR. Luciferase reporter gene assay detected the potential binding between miR-64 and X-box binding protein 1 (XBP1). Cancer cells were transfected with specific plasmids of XBP1, followed by MTT experiment and Ttranswell assay to assess invasion and proliferation. miR-64 was highly expressed in liver cancer cells and positively correlated with cell proliferation, invasion, and metastasis. miR-64 targeted and inhibited XBP1 expression. Overexpression of miR-64 significantly resulted in increased cell viability and invasion. Taken altogether, miR-64 promotes liver cancer through inhibiting XBP1, providing insight into miR-64-based targeted therapy against liver cancer." @default.
- W3179721071 created "2021-07-19" @default.
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- W3179721071 date "2021-08-01" @default.
- W3179721071 modified "2023-09-27" @default.
- W3179721071 title "MicroRNA-64 Promotes Progression of Liver Cancer Through Targeting X-Box Binding Protein 1 (XBP1)" @default.
- W3179721071 doi "https://doi.org/10.1166/jbt.2021.2737" @default.
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