Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179730861> ?p ?o ?g. }
- W3179730861 endingPage "108719" @default.
- W3179730861 startingPage "108719" @default.
- W3179730861 abstract "Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of glutamate is of paramount importance for normal brain function and relies on an intricate metabolic collaboration between neurons and astrocytes. Glutamate is extensively recycled between neurons and astrocytes in a process known as the glutamate-glutamine cycle. The recycling of glutamate is closely linked to brain energy metabolism and is essential to sustain glutamatergic neurotransmission. However, a considerable amount of glutamate is also metabolized and serves as a metabolic hub connecting glucose and amino acid metabolism in both neurons and astrocytes. Disruptions in glutamate clearance, leading to neuronal overstimulation and excitotoxicity, have been implicated in several neurodegenerative diseases. Furthermore, the link between brain energy homeostasis and glutamate metabolism is gaining attention in several neurological conditions. In this review, we provide an overview of the dynamics of synaptic glutamate homeostasis and the underlying metabolic processes with a cellular focus on neurons and astrocytes. In particular, we review the recently discovered role of neuronal glutamate uptake in synaptic glutamate homeostasis and discuss current advances in cellular glutamate metabolism in the context of Alzheimer's disease and Huntington's disease. Understanding the intricate regulation of glutamate-dependent metabolic processes at the synapse will not only increase our insight into the metabolic mechanisms of glutamate homeostasis, but may reveal new metabolic targets to ameliorate neurodegeneration." @default.
- W3179730861 created "2021-07-19" @default.
- W3179730861 creator A5013198207 @default.
- W3179730861 creator A5014672129 @default.
- W3179730861 creator A5020753227 @default.
- W3179730861 creator A5040759848 @default.
- W3179730861 creator A5056110350 @default.
- W3179730861 creator A5060434388 @default.
- W3179730861 date "2021-09-01" @default.
- W3179730861 modified "2023-10-17" @default.
- W3179730861 title "Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration" @default.
- W3179730861 cites W118386170 @default.
- W3179730861 cites W1509365529 @default.
- W3179730861 cites W1511828264 @default.
- W3179730861 cites W1513628006 @default.
- W3179730861 cites W1513808048 @default.
- W3179730861 cites W1568074666 @default.
- W3179730861 cites W1644388421 @default.
- W3179730861 cites W1820155366 @default.
- W3179730861 cites W18347505 @default.
- W3179730861 cites W1896952141 @default.
- W3179730861 cites W1900227502 @default.
- W3179730861 cites W1942543173 @default.
- W3179730861 cites W1955394435 @default.
- W3179730861 cites W1964063168 @default.
- W3179730861 cites W1965044068 @default.
- W3179730861 cites W1965703692 @default.
- W3179730861 cites W1965902234 @default.
- W3179730861 cites W1966768428 @default.
- W3179730861 cites W1968322702 @default.
- W3179730861 cites W1969400861 @default.
- W3179730861 cites W1969713114 @default.
- W3179730861 cites W1971639674 @default.
- W3179730861 cites W1971719161 @default.
- W3179730861 cites W1972161610 @default.
- W3179730861 cites W1972188596 @default.
- W3179730861 cites W1972340177 @default.
- W3179730861 cites W1973049965 @default.
- W3179730861 cites W1973175579 @default.
- W3179730861 cites W1977451474 @default.
- W3179730861 cites W1978723069 @default.
- W3179730861 cites W1979436304 @default.
- W3179730861 cites W1979889191 @default.
- W3179730861 cites W1980770383 @default.
- W3179730861 cites W1981872171 @default.
- W3179730861 cites W1982228941 @default.
- W3179730861 cites W1982879661 @default.
- W3179730861 cites W1983197885 @default.
- W3179730861 cites W1983540399 @default.
- W3179730861 cites W1984089779 @default.
- W3179730861 cites W1985335404 @default.
- W3179730861 cites W1985459796 @default.
- W3179730861 cites W1987437287 @default.
- W3179730861 cites W1991701465 @default.
- W3179730861 cites W1992521533 @default.
- W3179730861 cites W1993418561 @default.
- W3179730861 cites W1993617599 @default.
- W3179730861 cites W1993891203 @default.
- W3179730861 cites W1994243055 @default.
- W3179730861 cites W1995297071 @default.
- W3179730861 cites W1997727568 @default.
- W3179730861 cites W1999150303 @default.
- W3179730861 cites W1999389160 @default.
- W3179730861 cites W1999631359 @default.
- W3179730861 cites W2000367085 @default.
- W3179730861 cites W2000791958 @default.
- W3179730861 cites W2001725826 @default.
- W3179730861 cites W2003410399 @default.
- W3179730861 cites W2004195391 @default.
- W3179730861 cites W2006251549 @default.
- W3179730861 cites W2009812273 @default.
- W3179730861 cites W2010484888 @default.
- W3179730861 cites W2011348009 @default.
- W3179730861 cites W2012601853 @default.
- W3179730861 cites W2012606399 @default.
- W3179730861 cites W2015747402 @default.
- W3179730861 cites W2016575029 @default.
- W3179730861 cites W2016763790 @default.
- W3179730861 cites W2017349018 @default.
- W3179730861 cites W2017901987 @default.
- W3179730861 cites W2022908550 @default.
- W3179730861 cites W2022999587 @default.
- W3179730861 cites W2025478209 @default.
- W3179730861 cites W2028002685 @default.
- W3179730861 cites W2029919028 @default.
- W3179730861 cites W2030071933 @default.
- W3179730861 cites W2030116713 @default.
- W3179730861 cites W2031878163 @default.
- W3179730861 cites W2034103437 @default.
- W3179730861 cites W2034175695 @default.
- W3179730861 cites W2034283216 @default.
- W3179730861 cites W2035351488 @default.
- W3179730861 cites W2035466313 @default.
- W3179730861 cites W2037959100 @default.
- W3179730861 cites W2039711331 @default.
- W3179730861 cites W2040934617 @default.
- W3179730861 cites W2042414264 @default.
- W3179730861 cites W2042422091 @default.