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- W3179776416 abstract "Alcohol use disorder (AUD) is one of the most common, but still poorly treated, psychiatric conditions. Developing new treatments requires a better understanding of the aetiology of symptoms and evaluation of novel therapeutic targets in preclinical studies. Recent developments in our understanding of the reinforcement‐based cognitive biases (RBCBs) that contribute to the development of AUD and its treatment offer new opportunities for both clinical and preclinical research. In this review, we first briefly describe psychological and cognitive theories that involve various aspects of reinforcement sensitivity in the development, maintenance, and recurrence of alcohol addiction. Furthermore, in separate sections, we describe studies investigating RBCBs and their neural, neurochemical, and pharmacological correlates, and we discuss possible interactions between RBCBs and trajectories of AUD. Finally, we describe how recent translational studies using state‐of‐the‐art animal models can facilitate our understanding of the role of reinforcement sensitivity and RBCBs in various aspects of AUD. LINKED ARTICLES This article is part of a themed issue on New discoveries and perspectives in mental and pain disorders. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.17/issuetoc" @default.
- W3179776416 created "2021-07-19" @default.
- W3179776416 creator A5015342296 @default.
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- W3179776416 creator A5087045730 @default.
- W3179776416 date "2021-07-29" @default.
- W3179776416 modified "2023-09-26" @default.
- W3179776416 title "Reinforcement‐based cognitive biases as vulnerability factors in alcohol addiction: From humans to animal models" @default.
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