FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179900590> ?p ?o ?g. }

• W3179900590 endingPage "112292" @default.
• W3179900590 startingPage "112292" @default.
• W3179900590 abstract "The ever-growing threat of drug-resistant pathogens and their biofilms based persistent, chronic infections has created an urgent call for new strategies to deal with multidrug resistant bacteria (MDR). Near-infrared (NIR) laser-induced photothermal treatment (PTT) of gold nanorods (AuNRs) disinfects microbes by local heating with low possibility to develop resistant. However, PTT disinfection strategy of AuNRs alone shows less efficiency in killing multidrug resistant strains (i.e. Methicillin-resistant Staphylococcus aureus, MRSA) and their matured biofilms. Herein, a novel synergistic chemo-photothermal integrated antimicrobial platform (P(Cip-b-CB)-AuNRs) was fabricated which show enhanced killing efficiency against MRSA in both planktonic and biofilm phenotypes. Polymethacrylate copolymers with pendant ciprofloxacin (Cip) and the carboxyl betaine groups (P(Cip-b-CB)) were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization. P(Cip-b-CB) was decorated onto AuNRs via gold−thiol bond which resulted in AuNRs with acidic-induced surface charge-switchable activities and lipase triggered Cip release properties (P(Cip-b-CB)-AuNRs). The lower pH value and overexpress of lipase are characteristics for microenvironment of microbial infections and their biofilms, which ensure the targeting on, penetration into and on-demand release of Cip from the nanocomposites in bacterial infection sites and their biofilms. The bacterial cell membrane was disrupt by photothermal therapy which could improve its permeability and sensitivity to antibiotics, meanwhile lipase-triggered release of Cip ensures a high concentration of antibiotics at the site of bacterial infection. Besides their NIR induced PTT disinfection activities, the increased local temperature generated by NIR light irradiation accelerated Cip release which further enhanced the antibacterial efficiency, leading to synergistic antibacterial activities of chemo-photothermal therapy. Taken together, the designed synergistic chemo-photothermal integrated antimicrobial platform is a promising antibacterial agent for fighting MDR bacterial infections and their biofilms." @default.
• W3179900590 created "2021-07-19" @default.
• W3179900590 creator A5000437731 @default.
• W3179900590 creator A5009217219 @default.
• W3179900590 creator A5013862275 @default.
• W3179900590 creator A5033684869 @default.
• W3179900590 creator A5033867543 @default.
• W3179900590 creator A5049769892 @default.
• W3179900590 creator A5050226492 @default.
• W3179900590 creator A5053869162 @default.
• W3179900590 creator A5067584941 @default.
• W3179900590 date "2021-09-01" @default.
• W3179900590 modified "2023-09-25" @default.
• W3179900590 title "Ciprofloxacin conjugated gold nanorods with pH induced surface charge transformable activities to combat drug resistant bacteria and their biofilms" @default.
• W3179900590 cites W1855057195 @default.
• W3179900590 cites W2033781967 @default.
• W3179900590 cites W2036890691 @default.
• W3179900590 cites W2073556554 @default.
• W3179900590 cites W2176406695 @default.
• W3179900590 cites W2312435830 @default.
• W3179900590 cites W2339396284 @default.
• W3179900590 cites W2343726445 @default.
• W3179900590 cites W2407415576 @default.
• W3179900590 cites W2527952809 @default.
• W3179900590 cites W2549697151 @default.
• W3179900590 cites W2572187615 @default.
• W3179900590 cites W2747454487 @default.
• W3179900590 cites W2785454860 @default.
• W3179900590 cites W2805977284 @default.
• W3179900590 cites W2888964766 @default.
• W3179900590 cites W2889392915 @default.
• W3179900590 cites W2889529929 @default.
• W3179900590 cites W2894668217 @default.
• W3179900590 cites W2895174551 @default.
• W3179900590 cites W2896255116 @default.
• W3179900590 cites W2897876614 @default.
• W3179900590 cites W2899315312 @default.
• W3179900590 cites W2901561937 @default.
• W3179900590 cites W2908304439 @default.
• W3179900590 cites W2908459122 @default.
• W3179900590 cites W2936274291 @default.
• W3179900590 cites W2938042422 @default.
• W3179900590 cites W2942392835 @default.
• W3179900590 cites W2955358713 @default.
• W3179900590 cites W2976923567 @default.
• W3179900590 cites W2977110700 @default.
• W3179900590 cites W2992606422 @default.
• W3179900590 cites W3006762758 @default.
• W3179900590 cites W3011038856 @default.
• W3179900590 cites W3015360354 @default.
• W3179900590 cites W3028422537 @default.
• W3179900590 doi "https://doi.org/10.1016/j.msec.2021.112292" @default.
• W3179900590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34474843" @default.
• W3179900590 hasPublicationYear "2021" @default.
• W3179900590 type Work @default.
• W3179900590 sameAs 3179900590 @default.
• W3179900590 citedByCount "19" @default.
• W3179900590 countsByYear W31799005902021 @default.
• W3179900590 countsByYear W31799005902022 @default.
• W3179900590 countsByYear W31799005902023 @default.
• W3179900590 crossrefType "journal-article" @default.
• W3179900590 hasAuthorship W3179900590A5000437731 @default.
• W3179900590 hasAuthorship W3179900590A5009217219 @default.
• W3179900590 hasAuthorship W3179900590A5013862275 @default.
• W3179900590 hasAuthorship W3179900590A5033684869 @default.
• W3179900590 hasAuthorship W3179900590A5033867543 @default.
• W3179900590 hasAuthorship W3179900590A5049769892 @default.
• W3179900590 hasAuthorship W3179900590A5050226492 @default.
• W3179900590 hasAuthorship W3179900590A5053869162 @default.
• W3179900590 hasAuthorship W3179900590A5067584941 @default.
• W3179900590 hasConcept C126201875 @default.
• W3179900590 hasConcept C171250308 @default.
• W3179900590 hasConcept C178790620 @default.
• W3179900590 hasConcept C182606246 @default.
• W3179900590 hasConcept C185592680 @default.
• W3179900590 hasConcept C192562407 @default.
• W3179900590 hasConcept C2778512257 @default.
• W3179900590 hasConcept C4937899 @default.
• W3179900590 hasConcept C501593827 @default.
• W3179900590 hasConcept C523546767 @default.
• W3179900590 hasConcept C54355233 @default.
• W3179900590 hasConcept C55493867 @default.
• W3179900590 hasConcept C58123911 @default.
• W3179900590 hasConcept C86803240 @default.
• W3179900590 hasConcept C89423630 @default.
• W3179900590 hasConceptScore W3179900590C126201875 @default.
• W3179900590 hasConceptScore W3179900590C171250308 @default.
• W3179900590 hasConceptScore W3179900590C178790620 @default.
• W3179900590 hasConceptScore W3179900590C182606246 @default.
• W3179900590 hasConceptScore W3179900590C185592680 @default.
• W3179900590 hasConceptScore W3179900590C192562407 @default.
• W3179900590 hasConceptScore W3179900590C2778512257 @default.
• W3179900590 hasConceptScore W3179900590C4937899 @default.
• W3179900590 hasConceptScore W3179900590C501593827 @default.
• W3179900590 hasConceptScore W3179900590C523546767 @default.
• W3179900590 hasConceptScore W3179900590C54355233 @default.
• W3179900590 hasConceptScore W3179900590C55493867 @default.
• W3179900590 hasConceptScore W3179900590C58123911 @default.

• next