Matches in SemOpenAlex for { <https://semopenalex.org/work/W3180067217> ?p ?o ?g. }
- W3180067217 endingPage "379" @default.
- W3180067217 startingPage "369" @default.
- W3180067217 abstract "Prader–Willi syndrome (PWS) is a complex neurodevelopmental disorder, arising from a loss of paternity expressed genetic material on the imprinted chromosome locus 15q11-q13. Despite increasing clarity on the underlying genetic defects, the molecular basis of the condition remains poorly understood. Hypothalamic dysfunction is widely recognized as the basis of the core symptoms of PWS, which include a deficiency in growth hormone and reproductive hormones, circadian rhythm abnormalities, and a lack of satiety, leading to an extreme obesity, among others. Genome-wide gene expression analysis (transcriptomics) offers an unbiased interrogation of complex disease pathogenesis and a potential window into the dysregulated pathways involved in disease. In this chapter, we review the findings from recent work investigating the PWS hypothalamic transcriptome, discuss the significance of the findings in relation to the clinical presentation and molecular underpinnings of PWS, and highlight future research directions." @default.
- W3180067217 created "2021-07-19" @default.
- W3180067217 creator A5044245453 @default.
- W3180067217 date "2021-01-01" @default.
- W3180067217 modified "2023-10-12" @default.
- W3180067217 title "Transcriptomics of the Prader–Willi syndrome hypothalamus" @default.
- W3180067217 cites W1539043236 @default.
- W3180067217 cites W1922423641 @default.
- W3180067217 cites W1936565989 @default.
- W3180067217 cites W1964697541 @default.
- W3180067217 cites W1978715316 @default.
- W3180067217 cites W1979369962 @default.
- W3180067217 cites W1980782305 @default.
- W3180067217 cites W1990777401 @default.
- W3180067217 cites W1995647101 @default.
- W3180067217 cites W2007239552 @default.
- W3180067217 cites W2012362930 @default.
- W3180067217 cites W2014534727 @default.
- W3180067217 cites W2016392763 @default.
- W3180067217 cites W2019552384 @default.
- W3180067217 cites W2023733917 @default.
- W3180067217 cites W2030204732 @default.
- W3180067217 cites W2037208036 @default.
- W3180067217 cites W2045641591 @default.
- W3180067217 cites W2054275187 @default.
- W3180067217 cites W2061448757 @default.
- W3180067217 cites W2076783259 @default.
- W3180067217 cites W2094446860 @default.
- W3180067217 cites W2097330821 @default.
- W3180067217 cites W2100980426 @default.
- W3180067217 cites W2114729479 @default.
- W3180067217 cites W2118314203 @default.
- W3180067217 cites W2124140144 @default.
- W3180067217 cites W2125158041 @default.
- W3180067217 cites W2127621191 @default.
- W3180067217 cites W2128098876 @default.
- W3180067217 cites W2130410032 @default.
- W3180067217 cites W2131330949 @default.
- W3180067217 cites W2149070866 @default.
- W3180067217 cites W2153055403 @default.
- W3180067217 cites W2161649767 @default.
- W3180067217 cites W2161688901 @default.
- W3180067217 cites W2211882660 @default.
- W3180067217 cites W2214074259 @default.
- W3180067217 cites W2276757459 @default.
- W3180067217 cites W2336417482 @default.
- W3180067217 cites W2526037587 @default.
- W3180067217 cites W2526546796 @default.
- W3180067217 cites W2560760305 @default.
- W3180067217 cites W2573094324 @default.
- W3180067217 cites W2584332996 @default.
- W3180067217 cites W2586421092 @default.
- W3180067217 cites W2595343902 @default.
- W3180067217 cites W2614642503 @default.
- W3180067217 cites W2753908609 @default.
- W3180067217 cites W2772553845 @default.
- W3180067217 cites W2794512822 @default.
- W3180067217 cites W2802669613 @default.
- W3180067217 cites W2808798188 @default.
- W3180067217 cites W2898876238 @default.
- W3180067217 cites W2900044275 @default.
- W3180067217 cites W2907797628 @default.
- W3180067217 cites W2911076174 @default.
- W3180067217 cites W2950595506 @default.
- W3180067217 cites W2963367647 @default.
- W3180067217 cites W2985225008 @default.
- W3180067217 cites W2989971001 @default.
- W3180067217 cites W2999227631 @default.
- W3180067217 cites W3029566839 @default.
- W3180067217 cites W3043048574 @default.
- W3180067217 cites W3047690237 @default.
- W3180067217 cites W4210361961 @default.
- W3180067217 cites W4294216483 @default.
- W3180067217 doi "https://doi.org/10.1016/b978-0-12-820683-6.00027-0" @default.
- W3180067217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34238471" @default.
- W3180067217 hasPublicationYear "2021" @default.
- W3180067217 type Work @default.
- W3180067217 sameAs 3180067217 @default.
- W3180067217 citedByCount "6" @default.
- W3180067217 countsByYear W31800672172021 @default.
- W3180067217 countsByYear W31800672172022 @default.
- W3180067217 countsByYear W31800672172023 @default.
- W3180067217 crossrefType "book-chapter" @default.
- W3180067217 hasAuthorship W3180067217A5044245453 @default.
- W3180067217 hasConcept C104317684 @default.
- W3180067217 hasConcept C126322002 @default.
- W3180067217 hasConcept C150194340 @default.
- W3180067217 hasConcept C162317418 @default.
- W3180067217 hasConcept C2779134260 @default.
- W3180067217 hasConcept C54355233 @default.
- W3180067217 hasConcept C60644358 @default.
- W3180067217 hasConcept C71924100 @default.
- W3180067217 hasConcept C84597430 @default.
- W3180067217 hasConcept C86803240 @default.
- W3180067217 hasConceptScore W3180067217C104317684 @default.
- W3180067217 hasConceptScore W3180067217C126322002 @default.
- W3180067217 hasConceptScore W3180067217C150194340 @default.
- W3180067217 hasConceptScore W3180067217C162317418 @default.