Matches in SemOpenAlex for { <https://semopenalex.org/work/W3180113013> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3180113013 abstract "As protocells transitioned from structures bound by membranes made of simple amphiphiles, such as fatty acids, to structures containing phospholipid membranes, they became nearly impermeable to charged species. Yet, the ability to transport ions across membranes was vital to regulating cellular volume, pH homeostasis, generating energy and sensing the environment. For this reason, life evolved ion channels, protein structures surrounding water-filled pores in the membrane that facilitated ion transport. In contemporary cells, ion channels are complex protein assemblies. Could the same function be carried out, even if less efficiently and selectively, by much simpler peptides at the origins of life? To answer this question, we turned to trichogen (GAIV), an 11-residue peptide that was found to permeabilize membrane, causing leakage of the vesicle content including ions. Since GAIV is synthesized non-gnomically, it represents as excellent model for the earliest, poorly optimized channels. Understanding the mechanism by which short peptides, such as GAIV, mediate ion transport across membranes provides crucial information on the emergence, structure and the mechanism of action of the earliest ion channels. In this study, we used extensive molecular dynamics (MD) simulations to investigate directly spontaneous assembly of GAIV peptide and its structural dynamics, the formation of an induced water pore across the membrane and consequently ion conduction through the membrane." @default.
- W3180113013 created "2021-07-19" @default.
- W3180113013 creator A5035883012 @default.
- W3180113013 creator A5089542086 @default.
- W3180113013 date "2019-06-24" @default.
- W3180113013 modified "2023-09-27" @default.
- W3180113013 title "Emergence of Simple Ion Channels by Self-Assembly of Short Peptides" @default.
- W3180113013 hasPublicationYear "2019" @default.
- W3180113013 type Work @default.
- W3180113013 sameAs 3180113013 @default.
- W3180113013 citedByCount "0" @default.
- W3180113013 crossrefType "journal-article" @default.
- W3180113013 hasAuthorship W3180113013A5035883012 @default.
- W3180113013 hasAuthorship W3180113013A5089542086 @default.
- W3180113013 hasConcept C114032466 @default.
- W3180113013 hasConcept C12554922 @default.
- W3180113013 hasConcept C130316041 @default.
- W3180113013 hasConcept C137143421 @default.
- W3180113013 hasConcept C145148216 @default.
- W3180113013 hasConcept C147597530 @default.
- W3180113013 hasConcept C159467904 @default.
- W3180113013 hasConcept C170493617 @default.
- W3180113013 hasConcept C171250308 @default.
- W3180113013 hasConcept C178790620 @default.
- W3180113013 hasConcept C185592680 @default.
- W3180113013 hasConcept C192562407 @default.
- W3180113013 hasConcept C2779281246 @default.
- W3180113013 hasConcept C2780727160 @default.
- W3180113013 hasConcept C41625074 @default.
- W3180113013 hasConcept C50254741 @default.
- W3180113013 hasConcept C55493867 @default.
- W3180113013 hasConcept C59593255 @default.
- W3180113013 hasConcept C86803240 @default.
- W3180113013 hasConcept C99975950 @default.
- W3180113013 hasConceptScore W3180113013C114032466 @default.
- W3180113013 hasConceptScore W3180113013C12554922 @default.
- W3180113013 hasConceptScore W3180113013C130316041 @default.
- W3180113013 hasConceptScore W3180113013C137143421 @default.
- W3180113013 hasConceptScore W3180113013C145148216 @default.
- W3180113013 hasConceptScore W3180113013C147597530 @default.
- W3180113013 hasConceptScore W3180113013C159467904 @default.
- W3180113013 hasConceptScore W3180113013C170493617 @default.
- W3180113013 hasConceptScore W3180113013C171250308 @default.
- W3180113013 hasConceptScore W3180113013C178790620 @default.
- W3180113013 hasConceptScore W3180113013C185592680 @default.
- W3180113013 hasConceptScore W3180113013C192562407 @default.
- W3180113013 hasConceptScore W3180113013C2779281246 @default.
- W3180113013 hasConceptScore W3180113013C2780727160 @default.
- W3180113013 hasConceptScore W3180113013C41625074 @default.
- W3180113013 hasConceptScore W3180113013C50254741 @default.
- W3180113013 hasConceptScore W3180113013C55493867 @default.
- W3180113013 hasConceptScore W3180113013C59593255 @default.
- W3180113013 hasConceptScore W3180113013C86803240 @default.
- W3180113013 hasConceptScore W3180113013C99975950 @default.
- W3180113013 hasLocation W31801130131 @default.
- W3180113013 hasOpenAccess W3180113013 @default.
- W3180113013 hasPrimaryLocation W31801130131 @default.
- W3180113013 hasRelatedWork W1509327864 @default.
- W3180113013 hasRelatedWork W1589309289 @default.
- W3180113013 hasRelatedWork W1993984194 @default.
- W3180113013 hasRelatedWork W2011020621 @default.
- W3180113013 hasRelatedWork W2050414897 @default.
- W3180113013 hasRelatedWork W2058474241 @default.
- W3180113013 hasRelatedWork W2159877851 @default.
- W3180113013 hasRelatedWork W2199868862 @default.
- W3180113013 hasRelatedWork W2341870847 @default.
- W3180113013 hasRelatedWork W2403916482 @default.
- W3180113013 hasRelatedWork W2583759459 @default.
- W3180113013 hasRelatedWork W2743828414 @default.
- W3180113013 hasRelatedWork W2945443882 @default.
- W3180113013 hasRelatedWork W3033977315 @default.
- W3180113013 hasRelatedWork W3198454619 @default.
- W3180113013 hasRelatedWork W643356450 @default.
- W3180113013 hasRelatedWork W807365973 @default.
- W3180113013 hasRelatedWork W8143855 @default.
- W3180113013 hasRelatedWork W97847535 @default.
- W3180113013 hasRelatedWork W2184681623 @default.
- W3180113013 isParatext "false" @default.
- W3180113013 isRetracted "false" @default.
- W3180113013 magId "3180113013" @default.
- W3180113013 workType "article" @default.