Matches in SemOpenAlex for { <https://semopenalex.org/work/W3180382007> ?p ?o ?g. }
- W3180382007 endingPage "544" @default.
- W3180382007 startingPage "540" @default.
- W3180382007 abstract "A large number of protease inhibitors have been found from leeches, which are essential in various physiological and biological processes. In the curret study, a novel elastase inhibitor was purified and characterized from the leech of Hirudinaria manillensis, which was named HMEI-A. Primary structure analysis showed that HMEI-A belonged to a new family of proteins. HMEI-A exerted inhibitory effects on elastase and showed potent abilities to inhibit elastase with an inhibition constant (Ki) of 1.69 × 10-8 mol·L-1. Further study showed that HMEI-A inhibited the formation of neutrophil extracellular trap (NET). These results suggested that HMEI-A from the leech of H. manillensis is a novel elastase inhibitor which can suppress NET formation. It may play a significant role in blood-sucking of leeches and is a potential candidate as an anti-inflammatory agent." @default.
- W3180382007 created "2021-07-19" @default.
- W3180382007 creator A5006722654 @default.
- W3180382007 creator A5010238428 @default.
- W3180382007 creator A5019603661 @default.
- W3180382007 creator A5026809283 @default.
- W3180382007 creator A5030904455 @default.
- W3180382007 creator A5047669982 @default.
- W3180382007 creator A5081512782 @default.
- W3180382007 date "2021-07-01" @default.
- W3180382007 modified "2023-09-25" @default.
- W3180382007 title "Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis" @default.
- W3180382007 cites W1508206237 @default.
- W3180382007 cites W1608575731 @default.
- W3180382007 cites W1965435949 @default.
- W3180382007 cites W1977573362 @default.
- W3180382007 cites W1981334376 @default.
- W3180382007 cites W1988714638 @default.
- W3180382007 cites W2004756198 @default.
- W3180382007 cites W2013450677 @default.
- W3180382007 cites W2019210852 @default.
- W3180382007 cites W2061932620 @default.
- W3180382007 cites W2067543189 @default.
- W3180382007 cites W2067937943 @default.
- W3180382007 cites W2070117107 @default.
- W3180382007 cites W2090149802 @default.
- W3180382007 cites W2115959782 @default.
- W3180382007 cites W2129694418 @default.
- W3180382007 cites W2143152020 @default.
- W3180382007 cites W2157243313 @default.
- W3180382007 cites W2159498185 @default.
- W3180382007 cites W2172191543 @default.
- W3180382007 cites W2478242109 @default.
- W3180382007 cites W2743397125 @default.
- W3180382007 cites W2786765075 @default.
- W3180382007 cites W2808736826 @default.
- W3180382007 doi "https://doi.org/10.1016/s1875-5364(21)60054-7" @default.
- W3180382007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34247778" @default.
- W3180382007 hasPublicationYear "2021" @default.
- W3180382007 type Work @default.
- W3180382007 sameAs 3180382007 @default.
- W3180382007 citedByCount "1" @default.
- W3180382007 countsByYear W31803820072023 @default.
- W3180382007 crossrefType "journal-article" @default.
- W3180382007 hasAuthorship W3180382007A5006722654 @default.
- W3180382007 hasAuthorship W3180382007A5010238428 @default.
- W3180382007 hasAuthorship W3180382007A5019603661 @default.
- W3180382007 hasAuthorship W3180382007A5026809283 @default.
- W3180382007 hasAuthorship W3180382007A5030904455 @default.
- W3180382007 hasAuthorship W3180382007A5047669982 @default.
- W3180382007 hasAuthorship W3180382007A5081512782 @default.
- W3180382007 hasConcept C134018914 @default.
- W3180382007 hasConcept C136764020 @default.
- W3180382007 hasConcept C17077164 @default.
- W3180382007 hasConcept C180746962 @default.
- W3180382007 hasConcept C181199279 @default.
- W3180382007 hasConcept C185592680 @default.
- W3180382007 hasConcept C203014093 @default.
- W3180382007 hasConcept C2776317360 @default.
- W3180382007 hasConcept C2776714187 @default.
- W3180382007 hasConcept C2776914184 @default.
- W3180382007 hasConcept C2781044401 @default.
- W3180382007 hasConcept C28406088 @default.
- W3180382007 hasConcept C41008148 @default.
- W3180382007 hasConcept C55493867 @default.
- W3180382007 hasConcept C86803240 @default.
- W3180382007 hasConcept C98274493 @default.
- W3180382007 hasConceptScore W3180382007C134018914 @default.
- W3180382007 hasConceptScore W3180382007C136764020 @default.
- W3180382007 hasConceptScore W3180382007C17077164 @default.
- W3180382007 hasConceptScore W3180382007C180746962 @default.
- W3180382007 hasConceptScore W3180382007C181199279 @default.
- W3180382007 hasConceptScore W3180382007C185592680 @default.
- W3180382007 hasConceptScore W3180382007C203014093 @default.
- W3180382007 hasConceptScore W3180382007C2776317360 @default.
- W3180382007 hasConceptScore W3180382007C2776714187 @default.
- W3180382007 hasConceptScore W3180382007C2776914184 @default.
- W3180382007 hasConceptScore W3180382007C2781044401 @default.
- W3180382007 hasConceptScore W3180382007C28406088 @default.
- W3180382007 hasConceptScore W3180382007C41008148 @default.
- W3180382007 hasConceptScore W3180382007C55493867 @default.
- W3180382007 hasConceptScore W3180382007C86803240 @default.
- W3180382007 hasConceptScore W3180382007C98274493 @default.
- W3180382007 hasIssue "7" @default.
- W3180382007 hasLocation W31803820071 @default.
- W3180382007 hasLocation W31803820072 @default.
- W3180382007 hasOpenAccess W3180382007 @default.
- W3180382007 hasPrimaryLocation W31803820071 @default.
- W3180382007 hasRelatedWork W1965618318 @default.
- W3180382007 hasRelatedWork W2003408138 @default.
- W3180382007 hasRelatedWork W2063301225 @default.
- W3180382007 hasRelatedWork W2098109427 @default.
- W3180382007 hasRelatedWork W2144470297 @default.
- W3180382007 hasRelatedWork W2394939538 @default.
- W3180382007 hasRelatedWork W2491451478 @default.
- W3180382007 hasRelatedWork W2507793338 @default.
- W3180382007 hasRelatedWork W4225959193 @default.
- W3180382007 hasRelatedWork W4241370722 @default.