FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3180428305> ?p ?o ?g. }

• W3180428305 endingPage "513" @default.
• W3180428305 startingPage "511" @default.
• W3180428305 abstract "Background Vitamin B12 deficiency has been associated with a very wide spectrum of neurologic manifestations and the majority of cases occur in infants, pregnant women, and elderly people. In children, common neurological complications include neuropathy, neuropsychiatric features, infantile tremor syndrome, developmental delay, cognitive decline, spastic paraparesis due to subacute combined degeneration of cord, seizures, encephalopathy, extrapyramidal features, and neuropathy. Vitamin B12 is known to cause sensory ataxia, along with impaired position and vibration sense, as well as variable spasticity, as a part of subacute combined degeneration of the spinal cord. However, only a few cases of isolated cerebellar ataxia caused by vitamin B12 deficiency have been reported in published literature. Methods and results We are reporting a case of isolated cerebellar ataxia progressing over months in a 13-year-old boy. He also had associated knuckle hyperpigmentation, megaloblastic anemia and his magnetic resonance imaging of the brain was normal. Complete blood count showed hemoglobin of 8.6 gm/dl and peripheral smear showed macrovalocytes and few hypersegmented neutrophils. Serum vitamin B12 level was low (134 pg/mL). He was started on daily intramuscular vitamin B12 supplementation and he showed a favorable response after the first week. Conclusions Clinicians need to consider vitamin B12 deficiency as one of the rare etiological possibilities in children presenting with isolated subacute onset/chronic ataxia, as supplementation of this vitamin is likely to cause a complete reversal of ataxia in such children. Vitamin B12 deficiency has been associated with a very wide spectrum of neurologic manifestations and the majority of cases occur in infants, pregnant women, and elderly people. In children, common neurological complications include neuropathy, neuropsychiatric features, infantile tremor syndrome, developmental delay, cognitive decline, spastic paraparesis due to subacute combined degeneration of cord, seizures, encephalopathy, extrapyramidal features, and neuropathy. Vitamin B12 is known to cause sensory ataxia, along with impaired position and vibration sense, as well as variable spasticity, as a part of subacute combined degeneration of the spinal cord. However, only a few cases of isolated cerebellar ataxia caused by vitamin B12 deficiency have been reported in published literature. We are reporting a case of isolated cerebellar ataxia progressing over months in a 13-year-old boy. He also had associated knuckle hyperpigmentation, megaloblastic anemia and his magnetic resonance imaging of the brain was normal. Complete blood count showed hemoglobin of 8.6 gm/dl and peripheral smear showed macrovalocytes and few hypersegmented neutrophils. Serum vitamin B12 level was low (134 pg/mL). He was started on daily intramuscular vitamin B12 supplementation and he showed a favorable response after the first week. Clinicians need to consider vitamin B12 deficiency as one of the rare etiological possibilities in children presenting with isolated subacute onset/chronic ataxia, as supplementation of this vitamin is likely to cause a complete reversal of ataxia in such children." @default.
• W3180428305 created "2021-07-19" @default.
• W3180428305 creator A5001204433 @default.
• W3180428305 creator A5013830001 @default.
• W3180428305 creator A5014203677 @default.
• W3180428305 creator A5015028541 @default.
• W3180428305 creator A5026624294 @default.
• W3180428305 date "2021-10-01" @default.
• W3180428305 modified "2023-10-16" @default.
• W3180428305 title "Megaloblastic wobbliness: A reversible neurological condition" @default.
• W3180428305 cites W1967873911 @default.
• W3180428305 cites W1970053993 @default.
• W3180428305 cites W1974290676 @default.
• W3180428305 cites W2056539915 @default.
• W3180428305 cites W2059675298 @default.
• W3180428305 cites W2114212825 @default.
• W3180428305 cites W2799588758 @default.
• W3180428305 cites W2945609838 @default.
• W3180428305 cites W3035665979 @default.
• W3180428305 doi "https://doi.org/10.1016/j.clnesp.2021.06.019" @default.
• W3180428305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34620364" @default.
• W3180428305 hasPublicationYear "2021" @default.
• W3180428305 type Work @default.
• W3180428305 sameAs 3180428305 @default.
• W3180428305 citedByCount "0" @default.
• W3180428305 crossrefType "journal-article" @default.
• W3180428305 hasAuthorship W3180428305A5001204433 @default.
• W3180428305 hasAuthorship W3180428305A5013830001 @default.
• W3180428305 hasAuthorship W3180428305A5014203677 @default.
• W3180428305 hasAuthorship W3180428305A5015028541 @default.
• W3180428305 hasAuthorship W3180428305A5026624294 @default.
• W3180428305 hasConcept C118552586 @default.
• W3180428305 hasConcept C126322002 @default.
• W3180428305 hasConcept C141071460 @default.
• W3180428305 hasConcept C187212893 @default.
• W3180428305 hasConcept C2775892965 @default.
• W3180428305 hasConcept C2778621155 @default.
• W3180428305 hasConcept C2779012798 @default.
• W3180428305 hasConcept C2779405478 @default.
• W3180428305 hasConcept C2779750884 @default.
• W3180428305 hasConcept C2780168130 @default.
• W3180428305 hasConcept C2780906641 @default.
• W3180428305 hasConcept C2910828645 @default.
• W3180428305 hasConcept C42219234 @default.
• W3180428305 hasConcept C71924100 @default.
• W3180428305 hasConcept C90924648 @default.
• W3180428305 hasConceptScore W3180428305C118552586 @default.
• W3180428305 hasConceptScore W3180428305C126322002 @default.
• W3180428305 hasConceptScore W3180428305C141071460 @default.
• W3180428305 hasConceptScore W3180428305C187212893 @default.
• W3180428305 hasConceptScore W3180428305C2775892965 @default.
• W3180428305 hasConceptScore W3180428305C2778621155 @default.
• W3180428305 hasConceptScore W3180428305C2779012798 @default.
• W3180428305 hasConceptScore W3180428305C2779405478 @default.
• W3180428305 hasConceptScore W3180428305C2779750884 @default.
• W3180428305 hasConceptScore W3180428305C2780168130 @default.
• W3180428305 hasConceptScore W3180428305C2780906641 @default.
• W3180428305 hasConceptScore W3180428305C2910828645 @default.
• W3180428305 hasConceptScore W3180428305C42219234 @default.
• W3180428305 hasConceptScore W3180428305C71924100 @default.
• W3180428305 hasConceptScore W3180428305C90924648 @default.
• W3180428305 hasLocation W31804283051 @default.
• W3180428305 hasLocation W31804283052 @default.
• W3180428305 hasOpenAccess W3180428305 @default.
• W3180428305 hasPrimaryLocation W31804283051 @default.
• W3180428305 hasRelatedWork W2032108998 @default.
• W3180428305 hasRelatedWork W2103454594 @default.
• W3180428305 hasRelatedWork W2114212825 @default.
• W3180428305 hasRelatedWork W2151922950 @default.
• W3180428305 hasRelatedWork W2414334988 @default.
• W3180428305 hasRelatedWork W2469982683 @default.
• W3180428305 hasRelatedWork W2771074994 @default.
• W3180428305 hasRelatedWork W3084480196 @default.
• W3180428305 hasRelatedWork W3180428305 @default.
• W3180428305 hasRelatedWork W3199894846 @default.
• W3180428305 hasVolume "45" @default.
• W3180428305 isParatext "false" @default.
• W3180428305 isRetracted "false" @default.
• W3180428305 magId "3180428305" @default.
• W3180428305 workType "article" @default.