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- W3180512882 abstract "<h3>Background</h3> Genital infections burden and frequency of detrimental, non-Lactobacillus dominated vaginal microbiota (VMB) are high in sub-Saharan Africa. In countries such as Tanzania these challenges overlap with, and possibly contribute to, maternal complications. <h3>Objectives</h3> This study reported on prevalence of common, and often curable, Chlamydia trachomatis (CT), Neisseria gonorrhea (NG), Trichomonas vaginalis (TV), Mycoplasma genitalium (MG), human papillomavirus (HPV) infections, and on VMB composition among pregnant and post-delivery women in Pemba Island, Tanzania. <h3>Methods</h3> Vaginal swabs were collected at two timepoints during pregnancy and once after delivery by Pemba Biobank. Molecular assays were used to detect HPV, CT, NG, TV, and MG in samples from 438 individual women. IS-pro kit was used to characterize the VMB in a subset of women (n=90) based on 16S-23S rDNA interspacer region length. VMB were defined based on dominant species. Shannon diversity index, for number (richness) and relative abundance of species, was calculated and Mann-Whitney test used for analysis. <h3>Results</h3> In samples from 20.5% of the women, at least one pathogen was detected. Infection with HPV was the most prevalent (10.3%), followed by TV (7.1%), CT (4.6%), MG (2.1%), and NG (0%). The most common VMB were Lactobacillus-dominant during pregnancy (77% at first, and 81% at second timepoint), and non-Lactobacillus-dominant (73.9%) postdelivery. The Shannon diversity was lower during pregnancy than postdelivery (p=0.03). A decrease in VMB richness (p=0.02) was observed during pregnancy. Klebsiella species and Streptococcus anginosus were the most common microorganisms with pathogenic potential (pathobionts) at all timepoints. A high abundance of pathobionts was seen in women with non-Lactobacillus-dominant VMB. At second timepoint during pregnancy, 67% of the women carrying a genital pathogen had Lactobacillus iners-dominant VMB. <h3>Conclusion</h3> This study contributes knowledge on VMB composition and its changes during pregnancy and post-delivery, as well as simultaneous presence of pathobionts and genital pathogens." @default.
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- W3180512882 date "2021-07-01" @default.
- W3180512882 modified "2023-09-27" @default.
- W3180512882 title "P032 Vaginal microbiota characteristics and genital infections among pregnant women in Pemba island, Tanzania" @default.
- W3180512882 doi "https://doi.org/10.1136/sextrans-2021-sti.179" @default.
- W3180512882 hasPublicationYear "2021" @default.
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