FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3180685402> ?p ?o ?g. }

• W3180685402 abstract "To prevent SARS-CoV2 infection, mRNA vaccines have been developed including the mRNA-1273 (Moderna, Inc., Cambridge, MA, USA), a lipid nanoparticle-encapsulated mRNA vaccine.1 In some individuals, a cutaneous localized reaction with erythema and swelling on the upper arm at the injection site occurs which is referred as ‘COVID arm’.2, 3 It is considered as delayed-type hypersensitivity reaction (DTHR) and occurs mostly in individuals after vaccination with the Moderna vaccine, but rarely with other mRNA vaccines.2, 3 Whereas the clinical presentation is well characterized, the data on the histological features of this reaction are very sparse. The clinicopathological features of the patients and biopsies are summarized in Table 1. In all three patients, an erythema occurred on the left upper arm 6–7 days after the first injection of the Moderna (mRNA-1273 SARS-CoV2) vaccine. Skin biopsies were performed from the centre of the erythema in two patients and from the periphery in one patient. Histology revealed subtle and only very focal epidermal changes with spongiosis and exocytosis of a few lymphocytes in all biopsies. There was a perivascular and occasionally sleeve-like inflammatory infiltrate in the upper and mid dermis which was predominantly composed of small lymphocytes with an admixture of a variable number of eosinophilic granulocytes (Figs 1a and 2a,b). Immunophenotyping revealed that the lymphocytic component consisted almost exclusively of CD3-positive T cells with an admixture of only very few CD20-positive B cells. CD4-positive T cells accounted for 60–90% of all T cells and CD8-positive T cells for the remaining 10–40% (Fig. 1b,c). FOXP3-positive regulatory T-helper cells (Tregs) accounted for 5–10% of the lymphocytes. In addition, few CD56-positive T/NK cells, scattered CD138-positive plasma cells and CD123-positive plasmacytoid dendritic cells (PDCs) were present. The histological findings in our series are compatible with erythema annulare centrifugum (EAC) and are similar to the findings of previously reported six skin biopsies.2, 4, 5 Our data expand the immunophenotypic profile as they document the presence of few B cells including plasma cells, PDCs and Tregs. Post-vaccine EAC is an immunological reaction pattern which can be interpreted as a DHRT. It is distinct from the urticarial aspect of an acute-type allergic reaction (urticaria) and from contact allergic spongiotic dermatitis as classic localized DTHR. The predominance of CD4+ T cells can be explained by the strong response of CD4-positive type 1 helper T cells elicited by the vaccine.6 As in other hypersensitivity reactions, eosinophils are present at variable number. Post-vaccine EAC represents the histomorphological correlate for a localized DTHR known as COVID arm due mRNA vaccines. Remarkably, this immunological reaction pattern was also observed as a complication of COVID-19.7 The pathogenesis of EAC has not yet been elucidated in detail. Various triggers have been identified such as food components and drugs including immunotherapy.8 Lymphocytes from patients with EAC showed an increased release of IFN-γ.9 The COVID-19 mRNA vaccine BNT162b1 induces T-helper type 1-skewed T-cell immune responses with expansion of CD4+ and CD8+ T cells which are specific to the receptor-binding domain of the SARS-CoV-2 spike protein and produce interferon-γ.10 These findings support the concept of EAC as a T-cell-mediated DTHR in which IFN-γ is a crucial pathogenetic factor. It is still unclear which component of the Moderna vaccine is responsible for the induction of post-vaccine EAC. The mRNA encoding the spike protein itself seems not to be the primary culprit as also other mRNA vaccines very rarely induce the same reaction. In conclusion, the histomorphological correlate of the localized cutaneous DTHR to mRNA vaccines against SARS-CoV-2 corresponds to EAC as an immunological reaction pattern. The patients in this manuscript have given written informed consent to publication of their case details. None to declare." @default.
• W3180685402 created "2021-07-19" @default.
• W3180685402 creator A5010728477 @default.
• W3180685402 creator A5032513522 @default.
• W3180685402 creator A5041361796 @default.
• W3180685402 creator A5044776949 @default.
• W3180685402 creator A5047562457 @default.
• W3180685402 creator A5056222569 @default.
• W3180685402 date "2021-07-24" @default.
• W3180685402 modified "2023-09-26" @default.
• W3180685402 title "‘COVID arm’ – histological features of a delayed‐type hypersensitivity reaction to Moderna mRNA‐1273 SARS‐CoV2 vaccine" @default.
• W3180685402 cites W2057467261 @default.
• W3180685402 cites W2134112793 @default.
• W3180685402 cites W3090717270 @default.
• W3180685402 cites W3090844627 @default.
• W3180685402 cites W3117253039 @default.
• W3180685402 cites W3134328924 @default.
• W3180685402 cites W3150660033 @default.
• W3180685402 cites W3152594203 @default.
• W3180685402 cites W3160582230 @default.
• W3180685402 cites W4205483821 @default.
• W3180685402 doi "https://doi.org/10.1111/jdv.17506" @default.
• W3180685402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8447314" @default.
• W3180685402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34242422" @default.
• W3180685402 hasPublicationYear "2021" @default.
• W3180685402 type Work @default.
• W3180685402 sameAs 3180685402 @default.
• W3180685402 citedByCount "14" @default.
• W3180685402 countsByYear W31806854022021 @default.
• W3180685402 countsByYear W31806854022022 @default.
• W3180685402 crossrefType "journal-article" @default.
• W3180685402 hasAuthorship W3180685402A5010728477 @default.
• W3180685402 hasAuthorship W3180685402A5032513522 @default.
• W3180685402 hasAuthorship W3180685402A5041361796 @default.
• W3180685402 hasAuthorship W3180685402A5044776949 @default.
• W3180685402 hasAuthorship W3180685402A5047562457 @default.
• W3180685402 hasAuthorship W3180685402A5056222569 @default.
• W3180685402 hasBestOaLocation W31806854021 @default.
• W3180685402 hasConcept C142724271 @default.
• W3180685402 hasConcept C196166836 @default.
• W3180685402 hasConcept C203014093 @default.
• W3180685402 hasConcept C2778478263 @default.
• W3180685402 hasConcept C2779121184 @default.
• W3180685402 hasConcept C2779915019 @default.
• W3180685402 hasConcept C2780182102 @default.
• W3180685402 hasConcept C553184892 @default.
• W3180685402 hasConcept C57742111 @default.
• W3180685402 hasConcept C71924100 @default.
• W3180685402 hasConceptScore W3180685402C142724271 @default.
• W3180685402 hasConceptScore W3180685402C196166836 @default.
• W3180685402 hasConceptScore W3180685402C203014093 @default.
• W3180685402 hasConceptScore W3180685402C2778478263 @default.
• W3180685402 hasConceptScore W3180685402C2779121184 @default.
• W3180685402 hasConceptScore W3180685402C2779915019 @default.
• W3180685402 hasConceptScore W3180685402C2780182102 @default.
• W3180685402 hasConceptScore W3180685402C553184892 @default.
• W3180685402 hasConceptScore W3180685402C57742111 @default.
• W3180685402 hasConceptScore W3180685402C71924100 @default.
• W3180685402 hasIssue "11" @default.
• W3180685402 hasLocation W31806854021 @default.
• W3180685402 hasLocation W31806854022 @default.
• W3180685402 hasLocation W31806854023 @default.
• W3180685402 hasOpenAccess W3180685402 @default.
• W3180685402 hasPrimaryLocation W31806854021 @default.
• W3180685402 hasRelatedWork W101245337 @default.
• W3180685402 hasRelatedWork W1629037931 @default.
• W3180685402 hasRelatedWork W1989973775 @default.
• W3180685402 hasRelatedWork W2027869779 @default.
• W3180685402 hasRelatedWork W2038848310 @default.
• W3180685402 hasRelatedWork W2041629147 @default.
• W3180685402 hasRelatedWork W2051528762 @default.
• W3180685402 hasRelatedWork W2890026552 @default.
• W3180685402 hasRelatedWork W3180685402 @default.
• W3180685402 hasRelatedWork W4243517178 @default.
• W3180685402 hasVolume "35" @default.
• W3180685402 isParatext "false" @default.
• W3180685402 isRetracted "false" @default.
• W3180685402 magId "3180685402" @default.
• W3180685402 workType "article" @default.