Matches in SemOpenAlex for { <https://semopenalex.org/work/W3180738526> ?p ?o ?g. }
- W3180738526 endingPage "7206" @default.
- W3180738526 startingPage "7206" @default.
- W3180738526 abstract "The modern lifestyle brings both excessive fructose consumption and daily exposure to stress which could lead to metabolic disturbances and type 2 diabetes. Muscles are important points of glucose and lipid metabolism, with a crucial role in the maintenance of systemic energy homeostasis. We investigated whether 9-week fructose-enriched diet, with and without exposure to 4-week unpredictable stress, disturbs insulin signaling in the skeletal muscle of male rats and evaluated potential contributory roles of muscle lipid metabolism, glucocorticoid signaling and inflammation. The combination of fructose-enriched diet and stress increased peroxisome proliferator-activated receptors-α and -δ and stimulated lipid uptake, lipolysis and β-oxidation in the muscle of fructose-fed stressed rats. Combination of treatment also decreased systemic insulin sensitivity judged by lower R-QUICKI, and lowered muscle protein content and stimulatory phosphorylations of insulin receptor supstrate-1 and Akt, as well as the level of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor. At the same time, increased levels of protein tyrosine phosphatase-1B, nuclear factor-κB, tumor necrosis factor-α, were observed in the muscle of fructose-fed stressed rats. Based on these results, we propose that decreased glucocorticoid signaling in the skeletal muscle can make a setting for lipid-induced inflammation and the development of insulin resistance in fructose-fed stressed rats." @default.
- W3180738526 created "2021-07-19" @default.
- W3180738526 creator A5000194404 @default.
- W3180738526 creator A5001002379 @default.
- W3180738526 creator A5004307398 @default.
- W3180738526 creator A5004493415 @default.
- W3180738526 creator A5026567817 @default.
- W3180738526 creator A5056460386 @default.
- W3180738526 creator A5091647539 @default.
- W3180738526 date "2021-07-04" @default.
- W3180738526 modified "2023-10-05" @default.
- W3180738526 title "Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress" @default.
- W3180738526 cites W1601325022 @default.
- W3180738526 cites W1764140709 @default.
- W3180738526 cites W1786183411 @default.
- W3180738526 cites W1908031530 @default.
- W3180738526 cites W1968787277 @default.
- W3180738526 cites W1974793156 @default.
- W3180738526 cites W1978660595 @default.
- W3180738526 cites W1992339013 @default.
- W3180738526 cites W1998493448 @default.
- W3180738526 cites W2002923743 @default.
- W3180738526 cites W2005109641 @default.
- W3180738526 cites W2011421119 @default.
- W3180738526 cites W2013829707 @default.
- W3180738526 cites W2014671368 @default.
- W3180738526 cites W2016712537 @default.
- W3180738526 cites W2021871393 @default.
- W3180738526 cites W2023423740 @default.
- W3180738526 cites W2026295605 @default.
- W3180738526 cites W2026424902 @default.
- W3180738526 cites W2027689592 @default.
- W3180738526 cites W2030643479 @default.
- W3180738526 cites W2031637294 @default.
- W3180738526 cites W2033954596 @default.
- W3180738526 cites W2036845348 @default.
- W3180738526 cites W2042917553 @default.
- W3180738526 cites W2048488935 @default.
- W3180738526 cites W2049578370 @default.
- W3180738526 cites W2052506761 @default.
- W3180738526 cites W2059237923 @default.
- W3180738526 cites W2061519585 @default.
- W3180738526 cites W2065133613 @default.
- W3180738526 cites W2072243718 @default.
- W3180738526 cites W2077742058 @default.
- W3180738526 cites W2077991483 @default.
- W3180738526 cites W2079328243 @default.
- W3180738526 cites W2088262190 @default.
- W3180738526 cites W2096345851 @default.
- W3180738526 cites W2100232797 @default.
- W3180738526 cites W2103151410 @default.
- W3180738526 cites W2107662827 @default.
- W3180738526 cites W2109694255 @default.
- W3180738526 cites W2114671826 @default.
- W3180738526 cites W2115366040 @default.
- W3180738526 cites W2116629441 @default.
- W3180738526 cites W2117716503 @default.
- W3180738526 cites W2120489134 @default.
- W3180738526 cites W2120790798 @default.
- W3180738526 cites W2128138273 @default.
- W3180738526 cites W2129324527 @default.
- W3180738526 cites W2129445147 @default.
- W3180738526 cites W2135179675 @default.
- W3180738526 cites W2142083023 @default.
- W3180738526 cites W2152007541 @default.
- W3180738526 cites W2160524748 @default.
- W3180738526 cites W2163974655 @default.
- W3180738526 cites W2165613956 @default.
- W3180738526 cites W2166491773 @default.
- W3180738526 cites W2167790121 @default.
- W3180738526 cites W2170869159 @default.
- W3180738526 cites W2256190165 @default.
- W3180738526 cites W2269764438 @default.
- W3180738526 cites W2296267219 @default.
- W3180738526 cites W2508503562 @default.
- W3180738526 cites W2515697377 @default.
- W3180738526 cites W2536871625 @default.
- W3180738526 cites W2554921668 @default.
- W3180738526 cites W2558537355 @default.
- W3180738526 cites W2561422649 @default.
- W3180738526 cites W2656568860 @default.
- W3180738526 cites W2741004727 @default.
- W3180738526 cites W2741345040 @default.
- W3180738526 cites W2797136457 @default.
- W3180738526 cites W2800625592 @default.
- W3180738526 cites W2801380455 @default.
- W3180738526 cites W2806834451 @default.
- W3180738526 cites W2905987070 @default.
- W3180738526 cites W2955731873 @default.
- W3180738526 cites W2973136559 @default.
- W3180738526 cites W2998861678 @default.
- W3180738526 cites W3008268369 @default.
- W3180738526 cites W3025263382 @default.
- W3180738526 cites W4253244719 @default.
- W3180738526 doi "https://doi.org/10.3390/ijms22137206" @default.
- W3180738526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8269441" @default.
- W3180738526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34281257" @default.
- W3180738526 hasPublicationYear "2021" @default.