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• W3180744913 abstract "The cannabinoid CB1 receptor is the most abundant G protein coupled receptor (GPCR) in the central nervous system, which mediates the functional response to endocannabinoids and Cannabis compounds. A variety of ligands for CB1 receptors have been developed as promising drug candidates for the treatment of neurological disorders. New high-resolution structures of CB1 receptor in different functional states have significantly improved our molecular understanding of CB1 ligand interactions, selectivity, receptor activation and allosteric modulation. These advances have paved the way for development of novel ligands for different therapeutic applications. In this review, we describe the structural determinants for modulation of CB1 receptors by different types of ligands, as well as the differences between CB1 and its homologous, the CB2 receptor. LINKED ARTICLES: This article is part of a themed issue on Structure Guided Pharmacology of Membrane Proteins (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.14/issuetoc." @default.
• W3180744913 created "2021-07-19" @default.
• W3180744913 creator A5035737725 @default.
• W3180744913 creator A5048501797 @default.
• W3180744913 date "2021-08-12" @default.
• W3180744913 modified "2023-10-16" @default.
• W3180744913 title "Molecular basis for ligand modulation of the cannabinoid CB₁ receptor" @default.
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• W3180744913 doi "https://doi.org/10.1111/bph.15627" @default.
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