Matches in SemOpenAlex for { <https://semopenalex.org/work/W3180751330> ?p ?o ?g. }
- W3180751330 abstract "Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn's disease, suggesting it is a potential therapeutic target.This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets." @default.
- W3180751330 created "2021-07-19" @default.
- W3180751330 creator A5001641032 @default.
- W3180751330 creator A5004872611 @default.
- W3180751330 creator A5006775393 @default.
- W3180751330 creator A5007827508 @default.
- W3180751330 creator A5011176849 @default.
- W3180751330 creator A5011402003 @default.
- W3180751330 creator A5016217407 @default.
- W3180751330 creator A5018107648 @default.
- W3180751330 creator A5019352309 @default.
- W3180751330 creator A5021945660 @default.
- W3180751330 creator A5024004432 @default.
- W3180751330 creator A5026779717 @default.
- W3180751330 creator A5026788418 @default.
- W3180751330 creator A5027955775 @default.
- W3180751330 creator A5028044706 @default.
- W3180751330 creator A5028653276 @default.
- W3180751330 creator A5035504682 @default.
- W3180751330 creator A5036752858 @default.
- W3180751330 creator A5040217879 @default.
- W3180751330 creator A5045428672 @default.
- W3180751330 creator A5046698872 @default.
- W3180751330 creator A5052693979 @default.
- W3180751330 creator A5054973403 @default.
- W3180751330 creator A5056408708 @default.
- W3180751330 creator A5062248785 @default.
- W3180751330 creator A5073302847 @default.
- W3180751330 creator A5075155340 @default.
- W3180751330 creator A5079372832 @default.
- W3180751330 creator A5083660817 @default.
- W3180751330 creator A5085517085 @default.
- W3180751330 creator A5088404253 @default.
- W3180751330 creator A5089769587 @default.
- W3180751330 creator A5090099436 @default.
- W3180751330 date "2021-07-06" @default.
- W3180751330 modified "2023-10-14" @default.
- W3180751330 title "Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease" @default.
- W3180751330 cites W1596389679 @default.
- W3180751330 cites W1902117070 @default.
- W3180751330 cites W1964284218 @default.
- W3180751330 cites W1975705143 @default.
- W3180751330 cites W1977709885 @default.
- W3180751330 cites W1982401091 @default.
- W3180751330 cites W1984068087 @default.
- W3180751330 cites W1989568128 @default.
- W3180751330 cites W1997524935 @default.
- W3180751330 cites W1999388825 @default.
- W3180751330 cites W2002513358 @default.
- W3180751330 cites W2013624623 @default.
- W3180751330 cites W2026298980 @default.
- W3180751330 cites W2032623914 @default.
- W3180751330 cites W2036647854 @default.
- W3180751330 cites W2039671079 @default.
- W3180751330 cites W2051118414 @default.
- W3180751330 cites W2059145105 @default.
- W3180751330 cites W2073836327 @default.
- W3180751330 cites W2077955816 @default.
- W3180751330 cites W2080987301 @default.
- W3180751330 cites W2084830302 @default.
- W3180751330 cites W2087246553 @default.
- W3180751330 cites W2098499808 @default.
- W3180751330 cites W2099294505 @default.
- W3180751330 cites W2106036991 @default.
- W3180751330 cites W2108369987 @default.
- W3180751330 cites W2118743532 @default.
- W3180751330 cites W2128149258 @default.
- W3180751330 cites W2159582900 @default.
- W3180751330 cites W2163013660 @default.
- W3180751330 cites W2195303995 @default.
- W3180751330 cites W2248907500 @default.
- W3180751330 cites W2310542696 @default.
- W3180751330 cites W2324862792 @default.
- W3180751330 cites W2476039382 @default.
- W3180751330 cites W2528694978 @default.
- W3180751330 cites W2547154161 @default.
- W3180751330 cites W2547161721 @default.
- W3180751330 cites W2547214152 @default.
- W3180751330 cites W2547678018 @default.
- W3180751330 cites W2550031966 @default.
- W3180751330 cites W2550992104 @default.
- W3180751330 cites W2559004714 @default.
- W3180751330 cites W2559028527 @default.
- W3180751330 cites W2560857678 @default.
- W3180751330 cites W2571503386 @default.
- W3180751330 cites W2584228070 @default.
- W3180751330 cites W2594275078 @default.
- W3180751330 cites W2611696724 @default.
- W3180751330 cites W2613603864 @default.
- W3180751330 cites W2617668257 @default.
- W3180751330 cites W2734046086 @default.
- W3180751330 cites W2752951716 @default.
- W3180751330 cites W2763920193 @default.
- W3180751330 cites W2767230743 @default.
- W3180751330 cites W2767891136 @default.
- W3180751330 cites W2770092353 @default.
- W3180751330 cites W2789239950 @default.
- W3180751330 cites W2803664483 @default.
- W3180751330 cites W2804737546 @default.
- W3180751330 cites W2805983714 @default.