Matches in SemOpenAlex for { <https://semopenalex.org/work/W3180824529> ?p ?o ?g. }
- W3180824529 endingPage "18" @default.
- W3180824529 startingPage "7" @default.
- W3180824529 abstract "Glucagon is a potent glucose-elevating hormone that is secreted by pancreatic α-cells. While well-controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypoglycaemia, it is increasingly apparent that defects in the regulation of glucagon secretion contribute to impaired counter-regulation and hyperglycaemia in diabetes. It has therefore been proposed that pharmacological interventions targeting glucagon secretion/signalling can have great potential in improving glycaemic control of patients with diabetes. However, despite decades of research, a consensus on the precise mechanisms of glucose regulation of glucagon secretion is yet to be reached. Second messengers are a group of small intracellular molecules that relay extracellular signals to the intracellular signalling cascade, modulating cellular functions. There is a growing body of evidence that second messengers, such as cAMP and Ca2+, play critical roles in α-cell glucose-sensing and glucagon secretion. In this review, we discuss the impact of second messengers on α-cell electrical activity, intracellular Ca2+ dynamics and cell exocytosis. We highlight the possibility that the interaction between different second messengers may play a key role in the glucose-regulation of glucagon secretion." @default.
- W3180824529 created "2021-07-19" @default.
- W3180824529 creator A5024329533 @default.
- W3180824529 creator A5046482887 @default.
- W3180824529 date "2022-03-01" @default.
- W3180824529 modified "2023-10-16" @default.
- W3180824529 title "Regulation of α‐cell glucagon secretion: The role of second messengers" @default.
- W3180824529 cites W1492821183 @default.
- W3180824529 cites W1498846294 @default.
- W3180824529 cites W1530967097 @default.
- W3180824529 cites W1571595997 @default.
- W3180824529 cites W1591245254 @default.
- W3180824529 cites W1608643486 @default.
- W3180824529 cites W1907518241 @default.
- W3180824529 cites W1964812502 @default.
- W3180824529 cites W1964830836 @default.
- W3180824529 cites W1965398610 @default.
- W3180824529 cites W1968498807 @default.
- W3180824529 cites W1970723166 @default.
- W3180824529 cites W1970911184 @default.
- W3180824529 cites W1983286754 @default.
- W3180824529 cites W1983396112 @default.
- W3180824529 cites W1984541901 @default.
- W3180824529 cites W1985501043 @default.
- W3180824529 cites W1988801692 @default.
- W3180824529 cites W1992753036 @default.
- W3180824529 cites W1995274673 @default.
- W3180824529 cites W1995896550 @default.
- W3180824529 cites W1997883454 @default.
- W3180824529 cites W1998983314 @default.
- W3180824529 cites W1999722905 @default.
- W3180824529 cites W2001180476 @default.
- W3180824529 cites W2002770807 @default.
- W3180824529 cites W2009127988 @default.
- W3180824529 cites W2009724144 @default.
- W3180824529 cites W2009765916 @default.
- W3180824529 cites W2010820226 @default.
- W3180824529 cites W2011151996 @default.
- W3180824529 cites W2012064273 @default.
- W3180824529 cites W2014131324 @default.
- W3180824529 cites W2014716037 @default.
- W3180824529 cites W2015746168 @default.
- W3180824529 cites W2021517048 @default.
- W3180824529 cites W2021920528 @default.
- W3180824529 cites W2025233052 @default.
- W3180824529 cites W2025993954 @default.
- W3180824529 cites W2026272591 @default.
- W3180824529 cites W2028731653 @default.
- W3180824529 cites W2029559333 @default.
- W3180824529 cites W2030386197 @default.
- W3180824529 cites W2032015223 @default.
- W3180824529 cites W2032445998 @default.
- W3180824529 cites W2037789705 @default.
- W3180824529 cites W2039629780 @default.
- W3180824529 cites W2041346929 @default.
- W3180824529 cites W2041526142 @default.
- W3180824529 cites W2041733763 @default.
- W3180824529 cites W2042669615 @default.
- W3180824529 cites W2042950885 @default.
- W3180824529 cites W2044851240 @default.
- W3180824529 cites W2046901610 @default.
- W3180824529 cites W2048335012 @default.
- W3180824529 cites W2050636523 @default.
- W3180824529 cites W2051338604 @default.
- W3180824529 cites W2053936620 @default.
- W3180824529 cites W2054111620 @default.
- W3180824529 cites W2054750378 @default.
- W3180824529 cites W2058024825 @default.
- W3180824529 cites W2058747947 @default.
- W3180824529 cites W2059328843 @default.
- W3180824529 cites W2062524235 @default.
- W3180824529 cites W2062589221 @default.
- W3180824529 cites W2064908943 @default.
- W3180824529 cites W2065492264 @default.
- W3180824529 cites W2068377236 @default.
- W3180824529 cites W2068443011 @default.
- W3180824529 cites W2072682099 @default.
- W3180824529 cites W2073736156 @default.
- W3180824529 cites W2074528335 @default.
- W3180824529 cites W2083322345 @default.
- W3180824529 cites W2084948079 @default.
- W3180824529 cites W2085275630 @default.
- W3180824529 cites W2086294808 @default.
- W3180824529 cites W2086687315 @default.
- W3180824529 cites W2092834109 @default.
- W3180824529 cites W2093284652 @default.
- W3180824529 cites W2099084891 @default.
- W3180824529 cites W2101814428 @default.
- W3180824529 cites W2102877564 @default.
- W3180824529 cites W2103121999 @default.
- W3180824529 cites W2105951582 @default.
- W3180824529 cites W2106036385 @default.
- W3180824529 cites W2106259414 @default.
- W3180824529 cites W2106340518 @default.
- W3180824529 cites W2106657141 @default.
- W3180824529 cites W2109770201 @default.
- W3180824529 cites W2113192133 @default.
- W3180824529 cites W2113278846 @default.