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- W3180982014 abstract "Allergic diseases, including atopic dermatitis (AD), induce type 2 helper T (Th2) cell-dominant immune responses. Miquelianin (quercetin 3-O-glucuronide, MQL) is an active compound in Rosae multiflorae fructus extract with anti-allergic properties. Here, we investigate the anti-allergic effects of MQL in an ovalbumin (OVA)-induced Th2-dominant mouse model and the associated mechanisms. Oral MQL suppressed cytokine and IL-2 production and proliferation of Th2 cells and upregulated heme oxygenase-1 (HO-1) in splenocytes. Ex vivo MQL suppressed Th1- and Th2-related immune responses by inhibiting CD4+ T cell proliferation, and upregulated HO-1 in CD4+ T cells by activating C-Raf–ERK1/2–Nrf2 pathway via induction of reactive oxygen species generation. In a trimellitic anhydride-induced AD-like mouse model, both topical and oral MQL ameliorated AD symptoms by suppressing Th2 immune responses. Our results suggest that MQL is a potential therapeutic agent for CD4+ T cell-mediated diseases, including allergic diseases." @default.
- W3180982014 created "2021-07-19" @default.
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- W3180982014 date "2021-07-13" @default.
- W3180982014 modified "2023-10-13" @default.
- W3180982014 title "Miquelianin Inhibits Allergic Responses in Mice by Suppressing CD4+ T Cell Proliferation" @default.
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- W3180982014 doi "https://doi.org/10.3390/antiox10071120" @default.
- W3180982014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8301087" @default.
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