FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3181024885> ?p ?o ?g. }

• W3181024885 abstract "Temperate phages (active prophages induced from bacteria) help control pathogenicity, modulate community structure, and maintain gut homeostasis 1 . Complete phage genome sequences are indispensable for understanding phage biology. Traditional plaque techniques are inapplicable to temperate phages due to the lysogenicity of these phages, which curb the identification and characterization of temperate phages. Existing in silico tools for prophage prediction usually fail to detect accurate and complete temperate phage genomes 2–5 . In this study, by a novel computational method mining both the integrated active prophages and their spontaneously induced forms (temperate phages), we obtained 192,326 complete temperate phage genomes from bacterial next-generation sequencing (NGS) data, hence expanded the existing number of complete temperate phage genomes by more than 100-fold. The reliability of our method was validated by wet-lab experiments. The experiments demonstrated that our method can accurately determine the complete genome sequences of the temperate phages, with exact flanking sites ( attP and attB sites), outperforming other state-of-the-art prophage prediction methods. Our analysis indicates that temperate phages are likely to function in the evolution of microbes by 1) cross-infecting different bacterial host species; 2) transferring antibiotic resistance and virulence genes; and 3) interacting with hosts through restriction-modification and CRISPR/anti-CRISPR systems. This work provides a comprehensive complete temperate phage genome database and relevant information, which can serve as a valuable resource for phage research." @default.
• W3181024885 created "2021-07-19" @default.
• W3181024885 creator A5000169719 @default.
• W3181024885 creator A5002703845 @default.
• W3181024885 creator A5003880960 @default.
• W3181024885 creator A5009069936 @default.
• W3181024885 creator A5009962684 @default.
• W3181024885 creator A5010276529 @default.
• W3181024885 creator A5036569823 @default.
• W3181024885 creator A5037433135 @default.
• W3181024885 creator A5045599780 @default.
• W3181024885 creator A5046303550 @default.
• W3181024885 creator A5053095942 @default.
• W3181024885 creator A5056714859 @default.
• W3181024885 creator A5068306950 @default.
• W3181024885 creator A5069638807 @default.
• W3181024885 creator A5070403561 @default.
• W3181024885 creator A5078370564 @default.
• W3181024885 creator A5083428910 @default.
• W3181024885 creator A5088670866 @default.
• W3181024885 date "2021-07-15" @default.
• W3181024885 modified "2023-09-25" @default.
• W3181024885 title "Mining bacterial NGS data vastly expands the complete genomes of temperate phages" @default.
• W3181024885 cites W1826681000 @default.
• W3181024885 cites W1957125121 @default.
• W3181024885 cites W1976907618 @default.
• W3181024885 cites W1977893904 @default.
• W3181024885 cites W1985776863 @default.
• W3181024885 cites W2002650712 @default.
• W3181024885 cites W2030640784 @default.
• W3181024885 cites W2034134994 @default.
• W3181024885 cites W2043083543 @default.
• W3181024885 cites W2043522409 @default.
• W3181024885 cites W2047032063 @default.
• W3181024885 cites W2050783903 @default.
• W3181024885 cites W2055101979 @default.
• W3181024885 cites W2055822804 @default.
• W3181024885 cites W2060181264 @default.
• W3181024885 cites W2060573994 @default.
• W3181024885 cites W2063756105 @default.
• W3181024885 cites W2067791889 @default.
• W3181024885 cites W2076796342 @default.
• W3181024885 cites W2078476027 @default.
• W3181024885 cites W2096093282 @default.
• W3181024885 cites W2099968189 @default.
• W3181024885 cites W2100363512 @default.
• W3181024885 cites W2101350700 @default.
• W3181024885 cites W2106822056 @default.
• W3181024885 cites W2119859604 @default.
• W3181024885 cites W2130124027 @default.
• W3181024885 cites W2131271579 @default.
• W3181024885 cites W2131781913 @default.
• W3181024885 cites W2132641202 @default.
• W3181024885 cites W2133253129 @default.
• W3181024885 cites W2133620956 @default.
• W3181024885 cites W2134852597 @default.
• W3181024885 cites W2141394464 @default.
• W3181024885 cites W2142428670 @default.
• W3181024885 cites W2151183612 @default.
• W3181024885 cites W2156607023 @default.
• W3181024885 cites W2157235926 @default.
• W3181024885 cites W2158406706 @default.
• W3181024885 cites W2159284171 @default.
• W3181024885 cites W2171434257 @default.
• W3181024885 cites W2173913502 @default.
• W3181024885 cites W2294361662 @default.
• W3181024885 cites W2345791363 @default.
• W3181024885 cites W2472063060 @default.
• W3181024885 cites W2475445019 @default.
• W3181024885 cites W2521519758 @default.
• W3181024885 cites W2571820890 @default.
• W3181024885 cites W2747183034 @default.
• W3181024885 cites W2757079914 @default.
• W3181024885 cites W2763831277 @default.
• W3181024885 cites W2790921906 @default.
• W3181024885 cites W2801432714 @default.
• W3181024885 cites W2803245377 @default.
• W3181024885 cites W2890546854 @default.
• W3181024885 cites W2901652748 @default.
• W3181024885 cites W2910721672 @default.
• W3181024885 cites W2919702830 @default.
• W3181024885 cites W2927961455 @default.
• W3181024885 cites W2974645752 @default.
• W3181024885 cites W3010746544 @default.
• W3181024885 cites W4247252467 @default.
• W3181024885 cites W4248046275 @default.
• W3181024885 doi "https://doi.org/10.1101/2021.07.15.452192" @default.
• W3181024885 hasPublicationYear "2021" @default.
• W3181024885 type Work @default.
• W3181024885 sameAs 3181024885 @default.
• W3181024885 citedByCount "3" @default.
• W3181024885 countsByYear W31810248852021 @default.
• W3181024885 countsByYear W31810248852022 @default.
• W3181024885 crossrefType "posted-content" @default.
• W3181024885 hasAuthorship W3181024885A5000169719 @default.
• W3181024885 hasAuthorship W3181024885A5002703845 @default.
• W3181024885 hasAuthorship W3181024885A5003880960 @default.
• W3181024885 hasAuthorship W3181024885A5009069936 @default.
• W3181024885 hasAuthorship W3181024885A5009962684 @default.
• W3181024885 hasAuthorship W3181024885A5010276529 @default.

• next