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• W3181208303 abstract "Abstract The understanding of HIV-1 pathogenesis and clinical progression is incomplete because of the variable contribution of host, immune and viral factors. The involvement of viral factors has been investigated in extreme clinical phenotypes from rapid progressors to long-term non-progressors (LTNPs). Among HIV-1 proteins, the envelope glycoprotein complex (Env) has concentrated many studies for its important role in the immune response and in the first steps of viral replication. In this study, we analyzed the contribution of 41 Envs from 24 patients with different clinical progression rates and viral loads (VLs), LTNP-Elite Controllers (LTNP-ECs); Viremic LTNPs (vLTNPs), and non-controller’s individuals contemporary to LTNPs or recent, named Old and Modern progressors. We analyzed the Env expression, the fusion and cell-to-cell transfer capacities as well as viral infectivity. The sequence and phylogenetic analysis of Envs were also performed. In every functional characteristic, the Envs from subjects with viral control (LTNP-ECs and vLTNPs) showed significant lower performance compared to those from the progressor individuals (Old and Modern). Regarding sequence analysis, the variable loops of the gp120 subunit of the Env (i.e., V2, V4 and mainly V5) of the progressor individuals showed longer and more glycosylated sequences than controller subjects. Therefore, HIV-1 Envs presenting poor viral functions and shorter sequences were associated with viremic control and the non-progressor clinical phenotype, whereas functional Envs were associated with the lack of virological control and progressor clinical phenotypes. These correlations support the central role of Env genotypic and phenotypic characteristics in the in vivo HIV-1 infection and pathogenesis. IMPORTANCE The role of the virus in the pathogenesis of HIV-1 infection has not been investigated in isolates from individuals with different progression rates. In this work, we studied the properties of the envelope glycoprotein complex (Env) in individuals with different progression rates to elucidate its role in pathogenesis. We estimated the Env expression, the CD4 binding, the fusion and cell-to-cell viral transfer capacities that affect the infectivity of the viral Envs in recombinant viruses. The Envs from individuals which control viral replication and lack clinical progression (LTNP-ECs and vLTNPs) showed lower functional capacities than from subjects with clinical progression (Old and Modern). The functional increase of the Envs characteristics was associated with an increase in viral infectivity and in increased length of variable loops and the number of glycosylation sites of the Env (gp120/SU). These results support the concept that viral characteristics contribute to viral infection and pathogenesis." @default.
• W3181208303 created "2021-07-19" @default.
• W3181208303 creator A5004140307 @default.
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• W3181208303 creator A5088003575 @default.
• W3181208303 date "2021-07-09" @default.
• W3181208303 modified "2023-10-17" @default.
• W3181208303 title "The characteristics of the HIV-1 Env glycoprotein contribute to viral pathogenesis" @default.
• W3181208303 cites W1586015366 @default.
• W3181208303 cites W1883609085 @default.
• W3181208303 cites W1898340442 @default.
• W3181208303 cites W1923928177 @default.
• W3181208303 cites W1963495157 @default.
• W3181208303 cites W1965019797 @default.
• W3181208303 cites W1969955685 @default.
• W3181208303 cites W1971777539 @default.
• W3181208303 cites W1972777241 @default.
• W3181208303 cites W1974477822 @default.
• W3181208303 cites W1976466060 @default.
• W3181208303 cites W1981164507 @default.
• W3181208303 cites W1981440980 @default.
• W3181208303 cites W1982721121 @default.
• W3181208303 cites W1986152436 @default.
• W3181208303 cites W1986207039 @default.
• W3181208303 cites W1989035987 @default.
• W3181208303 cites W1991614900 @default.
• W3181208303 cites W1991656500 @default.
• W3181208303 cites W1993328343 @default.
• W3181208303 cites W1995355944 @default.
• W3181208303 cites W1996183144 @default.
• W3181208303 cites W1996335506 @default.
• W3181208303 cites W1998541327 @default.
• W3181208303 cites W2001276044 @default.
• W3181208303 cites W2002574877 @default.
• W3181208303 cites W2002915433 @default.
• W3181208303 cites W2012659064 @default.
• W3181208303 cites W2016582810 @default.
• W3181208303 cites W2017519756 @default.
• W3181208303 cites W2017551575 @default.
• W3181208303 cites W2019559865 @default.
• W3181208303 cites W2020096299 @default.
• W3181208303 cites W2027501809 @default.
• W3181208303 cites W2027738518 @default.
• W3181208303 cites W2034053987 @default.
• W3181208303 cites W2035653019 @default.
• W3181208303 cites W2039473791 @default.
• W3181208303 cites W2043683168 @default.
• W3181208303 cites W2046584457 @default.
• W3181208303 cites W2049355625 @default.
• W3181208303 cites W2053002571 @default.
• W3181208303 cites W2055379037 @default.
• W3181208303 cites W2059804447 @default.
• W3181208303 cites W2060507246 @default.
• W3181208303 cites W2062148688 @default.
• W3181208303 cites W2064502505 @default.
• W3181208303 cites W2064930458 @default.
• W3181208303 cites W2069815189 @default.
• W3181208303 cites W2076366830 @default.
• W3181208303 cites W2078282991 @default.
• W3181208303 cites W2080702547 @default.
• W3181208303 cites W2089023942 @default.
• W3181208303 cites W2091706084 @default.
• W3181208303 cites W2092220076 @default.
• W3181208303 cites W2092821075 @default.
• W3181208303 cites W2097125112 @default.
• W3181208303 cites W2097538995 @default.
• W3181208303 cites W2098439468 @default.
• W3181208303 cites W2103160360 @default.
• W3181208303 cites W2103937124 @default.
• W3181208303 cites W2113282092 @default.
• W3181208303 cites W2120589083 @default.
• W3181208303 cites W2121921695 @default.
• W3181208303 cites W2123036936 @default.
• W3181208303 cites W2124662703 @default.
• W3181208303 cites W2125458901 @default.
• W3181208303 cites W2126887491 @default.
• W3181208303 cites W2128528264 @default.
• W3181208303 cites W2133443224 @default.
• W3181208303 cites W2136286344 @default.
• W3181208303 cites W2137113653 @default.
• W3181208303 cites W2139714275 @default.
• W3181208303 cites W2139948235 @default.
• W3181208303 cites W2141348363 @default.
• W3181208303 cites W2142401625 @default.
• W3181208303 cites W2142405752 @default.
• W3181208303 cites W2144413932 @default.
• W3181208303 cites W2148245437 @default.
• W3181208303 cites W2150330555 @default.
• W3181208303 cites W2152971024 @default.
• W3181208303 cites W2153778605 @default.
• W3181208303 cites W2154205595 @default.

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