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- W3181266640 abstract "Radical cystectomy is the primary treatment for muscle-invasive bladder cancer; however, approximately 50% of patients develop metastatic disease within 2 years of diagnosis, which results in dismal prognosis. Therefore, systemic treatment is important to improve the prognosis of muscle-invasive bladder cancer. Currently, several guidelines recommend cisplatin-based neoadjuvant chemotherapy before radical cystectomy, and adjuvant chemotherapy is recommended in patients who have not received neoadjuvant chemotherapy. Immune checkpoint inhibitors have recently become the standard treatment option for metastatic urothelial carcinoma. Owing to their clinical benefits, several immune checkpoint inhibitors, with or without other agents (including other immunotherapy, cytotoxic chemotherapy, and emerging agents such as antibody drug conjugates), are being extensively investigated in perioperative settings. Several studies for perioperative immunotherapy have shown that immune checkpoint inhibitors have promising efficacy with relatively low toxicity, and have explored the predictive molecular biomarkers. Herein, we review the current evidence and discuss the future perspectives of perioperative systemic treatment for muscle-invasive bladder cancer." @default.
- W3181266640 created "2021-07-19" @default.
- W3181266640 creator A5024828401 @default.
- W3181266640 creator A5084818663 @default.
- W3181266640 date "2021-07-04" @default.
- W3181266640 modified "2023-09-24" @default.
- W3181266640 title "Perioperative Systemic Treatment for Muscle-Invasive Bladder Cancer: Current Evidence and Future Perspectives" @default.
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- W3181266640 doi "https://doi.org/10.3390/ijms22137201" @default.
- W3181266640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8268978" @default.
- W3181266640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34281253" @default.
- W3181266640 hasPublicationYear "2021" @default.
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