FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3181280253> ?p ?o ?g. }

• W3181280253 endingPage "837" @default.
• W3181280253 startingPage "823" @default.
• W3181280253 abstract "Considered as one of the major reasons of sudden cardiac death, hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease. However, effective treatment for HCM is still lacking. Identification of hub gene may be a powerful tool for discovering potential therapeutic targets and candidate biomarkers.We analysed three gene expression datasets for HCM from the Gene Expression Omnibus. Two of them were merged by sva package. The merged dataset was used for analysis while the other dataset was used for validation. Following this, a weighted gene coexpression network analysis (WGCNA) was performed, and the key module most related to HCM was identified. Based on the intramodular connectivity, we identified the potential hub genes. Then, a receiver operating characteristic curve analysis was performed to verify the diagnostic values of hub genes. Finally, we validated changes of hub genes, for genetic transcription and protein expression levels, in datasets of HCM patients and myocardium of transverse aortic constriction (TAC) mice.In the merged dataset, a total of 455 differentially expressed genes (DEGs) were identified from normal and hypertrophic myocardium. In WGCNA, the blue module was identified as the key module and the genes in this module showed a high positive correlation with HCM. Functional enrichment analysis of DEGs and key module revealed that the extracellular matrix, fibrosis, and neurohormone pathways played important roles in HCM. FRZB, COL14A1, CRISPLD1, LUM, and sFRP4 were identified as hub genes in the key module. These genes showed a good predictive value for HCM and were significantly up-regulated in HCM patients and TAC mice. We also found protein expression of LUM and sFRP4 increased in myocardium of TAC mice.This study revealed that five hub genes are involved in the occurrence and development of HCM, and they are potentially to be used as therapeutic targets and biomarkers for HCM." @default.
• W3181280253 created "2021-07-19" @default.
• W3181280253 creator A5002586476 @default.
• W3181280253 creator A5007830516 @default.
• W3181280253 creator A5018005821 @default.
• W3181280253 creator A5038250535 @default.
• W3181280253 creator A5040749068 @default.
• W3181280253 creator A5041664447 @default.
• W3181280253 creator A5042430714 @default.
• W3181280253 creator A5042950751 @default.
• W3181280253 creator A5045551923 @default.
• W3181280253 creator A5053579924 @default.
• W3181280253 creator A5054506269 @default.
• W3181280253 creator A5059788513 @default.
• W3181280253 date "2021-07-01" @default.
• W3181280253 modified "2023-10-02" @default.
• W3181280253 title "Identification of Underlying Hub Genes Associated with Hypertrophic Cardiomyopathy by Integrated Bioinformatics Analysis" @default.
• W3181280253 cites W1835047649 @default.
• W3181280253 cites W1860315828 @default.
• W3181280253 cites W1956332901 @default.
• W3181280253 cites W1966327575 @default.
• W3181280253 cites W1966644185 @default.
• W3181280253 cites W1976052678 @default.
• W3181280253 cites W1984606352 @default.
• W3181280253 cites W1984645774 @default.
• W3181280253 cites W2001686316 @default.
• W3181280253 cites W2004872126 @default.
• W3181280253 cites W2006617902 @default.
• W3181280253 cites W2006635776 @default.
• W3181280253 cites W2007081949 @default.
• W3181280253 cites W2016836965 @default.
• W3181280253 cites W2019119739 @default.
• W3181280253 cites W2021458745 @default.
• W3181280253 cites W2035618305 @default.
• W3181280253 cites W2050862994 @default.
• W3181280253 cites W2051811459 @default.
• W3181280253 cites W2060705109 @default.
• W3181280253 cites W2063254460 @default.
• W3181280253 cites W2067561333 @default.
• W3181280253 cites W2074156641 @default.
• W3181280253 cites W2082231490 @default.
• W3181280253 cites W2082676215 @default.
• W3181280253 cites W2097360283 @default.
• W3181280253 cites W2106330601 @default.
• W3181280253 cites W2113253187 @default.
• W3181280253 cites W2115673680 @default.
• W3181280253 cites W2116197923 @default.
• W3181280253 cites W2128914123 @default.
• W3181280253 cites W2142393775 @default.
• W3181280253 cites W2146512944 @default.
• W3181280253 cites W2147487806 @default.
• W3181280253 cites W2151046803 @default.
• W3181280253 cites W2153423299 @default.
• W3181280253 cites W2158626262 @default.
• W3181280253 cites W2159058635 @default.
• W3181280253 cites W2159675211 @default.
• W3181280253 cites W2173732482 @default.
• W3181280253 cites W2294592209 @default.
• W3181280253 cites W2355512956 @default.
• W3181280253 cites W2471875108 @default.
• W3181280253 cites W2507145112 @default.
• W3181280253 cites W2560017000 @default.
• W3181280253 cites W2727965221 @default.
• W3181280253 cites W2746624202 @default.
• W3181280253 cites W2765230035 @default.
• W3181280253 cites W2807214367 @default.
• W3181280253 cites W2887210220 @default.
• W3181280253 cites W2895934611 @default.
• W3181280253 cites W2905577111 @default.
• W3181280253 cites W2917605200 @default.
• W3181280253 cites W2943478561 @default.
• W3181280253 cites W2980538113 @default.
• W3181280253 cites W3000820803 @default.
• W3181280253 cites W3010009274 @default.
• W3181280253 cites W3025448947 @default.
• W3181280253 cites W3081807611 @default.
• W3181280253 cites W3096109950 @default.
• W3181280253 cites W4211100568 @default.
• W3181280253 cites W4239797347 @default.
• W3181280253 cites W4294541781 @default.
• W3181280253 cites W4362048428 @default.
• W3181280253 cites W74597864 @default.
• W3181280253 cites W765951455 @default.
• W3181280253 cites W2988009864 @default.
• W3181280253 doi "https://doi.org/10.2147/pgpm.s314880" @default.
• W3181280253 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8285300" @default.
• W3181280253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34285551" @default.
• W3181280253 hasPublicationYear "2021" @default.
• W3181280253 type Work @default.
• W3181280253 sameAs 3181280253 @default.
• W3181280253 citedByCount "3" @default.
• W3181280253 countsByYear W31812802532022 @default.
• W3181280253 countsByYear W31812802532023 @default.
• W3181280253 crossrefType "journal-article" @default.
• W3181280253 hasAuthorship W3181280253A5002586476 @default.
• W3181280253 hasAuthorship W3181280253A5007830516 @default.
• W3181280253 hasAuthorship W3181280253A5018005821 @default.
• W3181280253 hasAuthorship W3181280253A5038250535 @default.

• next