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• W3181330283 endingPage "672" @default.
• W3181330283 startingPage "661" @default.
• W3181330283 abstract "Abstract Objective: Recent cannabis exposure has been associated with lower rates of neurocognitive impairment in people with HIV (PWH). Cannabis’s anti-inflammatory properties may underlie this relationship by reducing chronic neuroinflammation in PWH. This study examined relations between cannabis use and inflammatory biomarkers in cerebrospinal fluid (CSF) and plasma, and cognitive correlates of these biomarkers within a community-based sample of PWH. Methods: 263 individuals were categorized into four groups: HIV− non-cannabis users ( n = 65), HIV+ non-cannabis users ( n = 105), HIV+ moderate cannabis users ( n = 62), and HIV+ daily cannabis users ( n = 31). Differences in pro-inflammatory biomarkers (IL-6, MCP-1/CCL2, IP-10/CXCL10, sCD14, sTNFR-II, TNF- α ) by study group were determined by Kruskal–Wallis tests. Multivariable linear regressions examined relationships between biomarkers and seven cognitive domains, adjusting for age, sex/gender, race, education, and current CD4 count. Results: HIV+ daily cannabis users showed lower MCP-1 and IP-10 levels in CSF compared to HIV+ non-cannabis users ( p = .015; p = .039) and were similar to HIV− non-cannabis users. Plasma biomarkers showed no differences by cannabis use. Among PWH, lower CSF MCP-1 and lower CSF IP-10 were associated with better learning performance (all p s < .05). Conclusions: Current daily cannabis use was associated with lower levels of pro-inflammatory chemokines implicated in HIV pathogenesis and these chemokines were linked to the cognitive domain of learning which is commonly impaired in PWH. Cannabinoid-related reductions of MCP-1 and IP-10, if confirmed, suggest a role for medicinal cannabis in the mitigation of persistent inflammation and cognitive impacts of HIV." @default.
• W3181330283 created "2021-07-19" @default.
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• W3181330283 date "2021-07-01" @default.
• W3181330283 modified "2023-10-16" @default.
• W3181330283 title "Daily Cannabis Use is Associated With Lower CNS Inflammation in People With HIV" @default.
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• W3181330283 doi "https://doi.org/10.1017/s1355617720001447" @default.
• W3181330283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8288448" @default.
• W3181330283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34261550" @default.
• W3181330283 hasPublicationYear "2021" @default.
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