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• W3181548570 abstract "A growing incidence, prevalence, morbidity and mortality from cardiovascular disease dictate an urgent need in identification of its risk factors and their pathogenetic links with coronary artery disease and stroke. Aging of the population is inevitably associated with an increasing prevalence of comorbid conditions. Among them are disorders of mineral homeostasis which, often being neglected, are clearly associated with major adverse cardiovascular events and cardiovascular death. Maintenance of mineral homeostasis in the human body is largely dependent on the formation of calciprotein particles (CPPs) which arise in the blood upon the binding of a mineral chaperone fetuin-A to nascent calcium phosphate crystals, thereby aggregating excessive calcium (Ca2+) and phosphate (PO4 3-), removing them from the bloodstream and preventing extraskeletal calcification. During the circulation, CPPs are internalised by arterial endothelial cells and provoke endothelial dysfunction through endothelial activation, endothelialto-mesenchymal transition and impairment of endothelial mechanotransduction. Animal studies demonstrated that regular intravenous injections of CPPs lead to intimal hyperplasia and adventitial/perivascular inflammation in the absence of any other cardiovascular risk factors, indicating pathophysiological importance of CPPs for cardiovascular disease. Further, a number of clinical studies suggested an association of an augmented serum calcification propensity or elevated CPP count with arterial hypertension, myocardial infarction, chronic brain ischemia, ischemic stroke and cardiovascular death in patients with chronic kidney disease (including those with end-stage renal disease as well as kidney transplant recipients) and individuals with a preserved renal function. Here, we critically discuss the pathophysiological consequences of CPP formation, mechanisms of their pathogenic effects, and potential therapeutic interventions." @default.
• W3181548570 created "2021-07-19" @default.
• W3181548570 creator A5051526142 @default.
• W3181548570 date "2021-07-01" @default.
• W3181548570 modified "2023-09-25" @default.
• W3181548570 title "Pathophysiological and clinical significance of mineral homeostasis disorders in the development of cardiovascular disease" @default.
• W3181548570 cites W1218089440 @default.
• W3181548570 cites W1580151493 @default.
• W3181548570 cites W1823050816 @default.
• W3181548570 cites W1914229765 @default.
• W3181548570 cites W1971529415 @default.
• W3181548570 cites W1972451748 @default.
• W3181548570 cites W1973948354 @default.
• W3181548570 cites W1990216816 @default.
• W3181548570 cites W1991525001 @default.
• W3181548570 cites W1992226521 @default.
• W3181548570 cites W2000936082 @default.
• W3181548570 cites W2004494117 @default.
• W3181548570 cites W2006076459 @default.
• W3181548570 cites W2011560262 @default.
• W3181548570 cites W2015445251 @default.
• W3181548570 cites W2036588459 @default.
• W3181548570 cites W2041793846 @default.
• W3181548570 cites W2043919846 @default.
• W3181548570 cites W2045888765 @default.
• W3181548570 cites W2049262743 @default.
• W3181548570 cites W2054540776 @default.
• W3181548570 cites W2055001542 @default.
• W3181548570 cites W2055144429 @default.
• W3181548570 cites W2055620105 @default.
• W3181548570 cites W2058579856 @default.
• W3181548570 cites W2060412589 @default.
• W3181548570 cites W2065133151 @default.
• W3181548570 cites W2067838633 @default.
• W3181548570 cites W2068755420 @default.
• W3181548570 cites W2085051977 @default.
• W3181548570 cites W2087787127 @default.
• W3181548570 cites W2090290501 @default.
• W3181548570 cites W2091781936 @default.
• W3181548570 cites W2101403851 @default.
• W3181548570 cites W2103888323 @default.
• W3181548570 cites W2108152450 @default.
• W3181548570 cites W2109006940 @default.
• W3181548570 cites W2113300052 @default.
• W3181548570 cites W2119360186 @default.
• W3181548570 cites W2121791481 @default.
• W3181548570 cites W2123432729 @default.
• W3181548570 cites W2130828535 @default.
• W3181548570 cites W2134566930 @default.
• W3181548570 cites W2137474409 @default.
• W3181548570 cites W2141306851 @default.
• W3181548570 cites W2142090475 @default.
• W3181548570 cites W2148134624 @default.
• W3181548570 cites W2150181374 @default.
• W3181548570 cites W2153942663 @default.
• W3181548570 cites W2155193274 @default.
• W3181548570 cites W2158070898 @default.
• W3181548570 cites W2158561625 @default.
• W3181548570 cites W2161706310 @default.
• W3181548570 cites W2161988331 @default.
• W3181548570 cites W2169669025 @default.
• W3181548570 cites W2228897323 @default.
• W3181548570 cites W2271287115 @default.
• W3181548570 cites W2275204317 @default.
• W3181548570 cites W2293372013 @default.
• W3181548570 cites W2294532682 @default.
• W3181548570 cites W2300272821 @default.
• W3181548570 cites W2327520940 @default.
• W3181548570 cites W2397076296 @default.
• W3181548570 cites W2400300049 @default.
• W3181548570 cites W2415180002 @default.
• W3181548570 cites W2418443178 @default.
• W3181548570 cites W2464505299 @default.
• W3181548570 cites W2496091118 @default.
• W3181548570 cites W2518807334 @default.
• W3181548570 cites W2524387459 @default.
• W3181548570 cites W2535718410 @default.
• W3181548570 cites W2538854486 @default.
• W3181548570 cites W2557337009 @default.
• W3181548570 cites W2560519247 @default.
• W3181548570 cites W2562981088 @default.
• W3181548570 cites W2570062782 @default.
• W3181548570 cites W2586038252 @default.
• W3181548570 cites W2588577136 @default.
• W3181548570 cites W2593144838 @default.
• W3181548570 cites W2617402343 @default.
• W3181548570 cites W2620594759 @default.
• W3181548570 cites W2637172877 @default.
• W3181548570 cites W2734506097 @default.
• W3181548570 cites W2734965439 @default.
• W3181548570 cites W2748107860 @default.
• W3181548570 cites W2750495218 @default.
• W3181548570 cites W2753969754 @default.
• W3181548570 cites W2762816177 @default.
• W3181548570 cites W2765497308 @default.
• W3181548570 cites W2773766732 @default.
• W3181548570 cites W2781524776 @default.
• W3181548570 cites W2787428677 @default.

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