Matches in SemOpenAlex for { <https://semopenalex.org/work/W3181620688> ?p ?o ?g. }
- W3181620688 abstract "Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients typically present with a relapsing-remitting (RR) disease course, manifesting as sporadic attacks of neurological symptoms including ataxia, fatigue, and sensory impairment. While there are several effective disease-modifying therapies able to address the inflammatory relapses associated with RRMS, most patients will inevitably advance to a progressive disease course marked by a gradual and irreversible accrual of disabilities. Therapeutic intervention in progressive MS (PMS) suffers from a lack of well-characterized biological targets and, hence, a dearth of successful drugs. The few medications approved for the treatment of PMS are typically limited in their efficacy to active forms of the disease, have little impact on slowing degeneration, and fail to promote repair. In looking to address these unmet needs, the multifactorial therapeutic benefits of stem cell therapies are particularly compelling. Ostensibly providing neurotrophic support, immunomodulation and cell replacement, stem cell transplantation holds substantial promise in combatting the complex pathology of chronic neuroinflammation. Herein, we explore the current state of preclinical and clinical evidence supporting the use of stem cells in treating PMS and we discuss prospective hurdles impeding their translation into revolutionary regenerative medicines." @default.
- W3181620688 created "2021-07-19" @default.
- W3181620688 creator A5001612039 @default.
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- W3181620688 creator A5058920811 @default.
- W3181620688 creator A5078028585 @default.
- W3181620688 date "2021-07-09" @default.
- W3181620688 modified "2023-10-18" @default.
- W3181620688 title "Stem Cell Therapies for Progressive Multiple Sclerosis" @default.
- W3181620688 cites W1493585689 @default.
- W3181620688 cites W1718676046 @default.
- W3181620688 cites W1790809173 @default.
- W3181620688 cites W1943010815 @default.
- W3181620688 cites W1967750892 @default.
- W3181620688 cites W1968159361 @default.
- W3181620688 cites W1968513811 @default.
- W3181620688 cites W1970368333 @default.
- W3181620688 cites W1970600368 @default.
- W3181620688 cites W1971044205 @default.
- W3181620688 cites W1971218073 @default.
- W3181620688 cites W1973765063 @default.
- W3181620688 cites W1974469420 @default.
- W3181620688 cites W1980446723 @default.
- W3181620688 cites W1984954323 @default.
- W3181620688 cites W1986543208 @default.
- W3181620688 cites W1986628684 @default.
- W3181620688 cites W1987270591 @default.
- W3181620688 cites W1989180597 @default.
- W3181620688 cites W1993824683 @default.
- W3181620688 cites W1993970490 @default.
- W3181620688 cites W1994878371 @default.
- W3181620688 cites W1995922650 @default.
- W3181620688 cites W2000631468 @default.
- W3181620688 cites W2002145511 @default.
- W3181620688 cites W2002288888 @default.
- W3181620688 cites W2005355063 @default.
- W3181620688 cites W2006178657 @default.
- W3181620688 cites W2007128839 @default.
- W3181620688 cites W2007702618 @default.
- W3181620688 cites W2012283308 @default.
- W3181620688 cites W2019339732 @default.
- W3181620688 cites W2025274607 @default.
- W3181620688 cites W2025551721 @default.
- W3181620688 cites W2026383212 @default.
- W3181620688 cites W2027449023 @default.
- W3181620688 cites W2031038810 @default.
- W3181620688 cites W2031195065 @default.
- W3181620688 cites W2031472162 @default.
- W3181620688 cites W2034382093 @default.
- W3181620688 cites W2038428996 @default.
- W3181620688 cites W2046637170 @default.
- W3181620688 cites W2046941822 @default.
- W3181620688 cites W2047062145 @default.
- W3181620688 cites W2048082433 @default.
- W3181620688 cites W2051274614 @default.
- W3181620688 cites W2052301691 @default.
- W3181620688 cites W2052350227 @default.
- W3181620688 cites W2053362289 @default.
- W3181620688 cites W2055240008 @default.
- W3181620688 cites W2055569470 @default.
- W3181620688 cites W2056725513 @default.
- W3181620688 cites W2057641653 @default.
- W3181620688 cites W2058602216 @default.
- W3181620688 cites W2061344523 @default.
- W3181620688 cites W2061739297 @default.
- W3181620688 cites W2062521126 @default.
- W3181620688 cites W2063638559 @default.
- W3181620688 cites W2064256508 @default.
- W3181620688 cites W2068969996 @default.
- W3181620688 cites W2069307274 @default.
- W3181620688 cites W2069958858 @default.
- W3181620688 cites W2075603193 @default.
- W3181620688 cites W2077806591 @default.
- W3181620688 cites W2078609815 @default.
- W3181620688 cites W2078758159 @default.
- W3181620688 cites W2079322665 @default.
- W3181620688 cites W2079356804 @default.
- W3181620688 cites W2080431262 @default.
- W3181620688 cites W2081347853 @default.
- W3181620688 cites W2082470201 @default.
- W3181620688 cites W2082739503 @default.
- W3181620688 cites W2088341378 @default.
- W3181620688 cites W2094412198 @default.
- W3181620688 cites W2094613247 @default.
- W3181620688 cites W2096028032 @default.
- W3181620688 cites W2096219876 @default.
- W3181620688 cites W2096785977 @default.
- W3181620688 cites W2097114048 @default.
- W3181620688 cites W2106117542 @default.
- W3181620688 cites W2106226653 @default.
- W3181620688 cites W2107008240 @default.
- W3181620688 cites W2108005154 @default.
- W3181620688 cites W2108197744 @default.
- W3181620688 cites W2108538059 @default.
- W3181620688 cites W2111720594 @default.
- W3181620688 cites W2114190644 @default.
- W3181620688 cites W2115852450 @default.
- W3181620688 cites W2118818657 @default.