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- W3181673670 abstract "Abstract Background: In our previous study, we have found that PPARγ-silenced BMSCs decreased adipogenic differentiation, but increased osteogenic differentiation after being induced by doxycycline. We demonstrated biphasic calcium phosphate (BCP) scaffold coated with multilayer of hydroxyapatite/poly-L-Lactide (HA/PLLA) nanocomposites is an excellent substitute for damaged and defect bone in bone tissue engineering. Combination of biomaterial scaffolds and therapeutic agents could contribute to a more predictable outcome with the potential of inducing bone formation while preventing bacterial infection. The delivery of BMSCs into Dox implant scaffolds aiming at enhancing the influence of BMSCs on the biocompatibility of the Dox implant has not been reported yet. Methods: The Poly-lactic-co-glycolic acid-Methoxypolyethylene glycols (PLGA-mPEG) microspheres were prepared by encapsulating the doxycycline, and they were incorporated into three dimensional BCP scaffold to build a doxycycline sustained release system of BCP scaffold. The preprocessed BCP scaffold is present to tBMSCs, then tBMSCs viability, tBMSCs proliferation and differentiation capacities are detected in vitro . Results: The microspheres were uniformly loaded on the BCP scaffolds and the pore structure was not affected, the BCP/Dox scaffolds were a good porous scaffold for the sustained release Dox for 2 months. The BCP/Dox scaffolds could promote transfected tBMSCs adhesion, proliferation and osteogenic differentiation in vitro . Conclusions: The BCP/Dox scaffold is a suitable carrier for localized delivery of the Dox, and he BCP/Dox scaffolds could promote adhesion, proliferation and osteogenic differentiation of undifferentiated tBMSCs in vitro, but more work is needed to research to meet the demands of tissue engineering." @default.
- W3181673670 created "2021-07-19" @default.
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- W3181673670 date "2021-07-06" @default.
- W3181673670 modified "2023-10-16" @default.
- W3181673670 title "Biocompatibility and Bioactivity of BCP/Dox Scaffolds Containing Doxycycline Microspheres for Rat Silencing Pparγ Gene Transfected Bone Mesenchymal Stem Cells" @default.
- W3181673670 doi "https://doi.org/10.21203/rs.3.rs-630227/v1" @default.
- W3181673670 hasPublicationYear "2021" @default.
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