Matches in SemOpenAlex for { <https://semopenalex.org/work/W3181691036> ?p ?o ?g. }
- W3181691036 endingPage "109308" @default.
- W3181691036 startingPage "109308" @default.
- W3181691036 abstract "Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to identify commonalities in glial pathobiology across species and models. Mouse striatal astrocytes are fluorescence-activated cell sorted (FACS) from R6/2 and zQ175 mice, which respectively express exon1-only or full-length mHTT, and human astrocytes are generated either from human embryonic stem cells (hESCs) expressing full-length mHTT or from fetal striatal astrocytes transduced with exon1-only mHTT. Comparison of differential gene expression across these conditions, all with respect to normal HTT controls, reveals cell-type-specific changes in transcription common to both species, yet with differences that distinguish glia expressing truncated mHTT versus full-length mHTT. These data indicate that the differential gene expression of glia expressing truncated mHTT may differ from that of cells expressing full-length mHTT, while identifying a conserved set of dysregulated pathways in HD glia." @default.
- W3181691036 created "2021-07-19" @default.
- W3181691036 creator A5032967943 @default.
- W3181691036 creator A5035080848 @default.
- W3181691036 creator A5041897712 @default.
- W3181691036 creator A5048670055 @default.
- W3181691036 creator A5051896298 @default.
- W3181691036 creator A5069724247 @default.
- W3181691036 creator A5070481491 @default.
- W3181691036 creator A5073855506 @default.
- W3181691036 date "2021-07-01" @default.
- W3181691036 modified "2023-10-11" @default.
- W3181691036 title "Cell-intrinsic glial pathology is conserved across human and murine models of Huntington’s disease" @default.
- W3181691036 cites W1769569140 @default.
- W3181691036 cites W1833314573 @default.
- W3181691036 cites W1880941604 @default.
- W3181691036 cites W1933979928 @default.
- W3181691036 cites W1963487339 @default.
- W3181691036 cites W1965044068 @default.
- W3181691036 cites W1965271056 @default.
- W3181691036 cites W1970900916 @default.
- W3181691036 cites W1973055895 @default.
- W3181691036 cites W1973791782 @default.
- W3181691036 cites W1974897920 @default.
- W3181691036 cites W1976420135 @default.
- W3181691036 cites W1978842326 @default.
- W3181691036 cites W1980775054 @default.
- W3181691036 cites W1987426179 @default.
- W3181691036 cites W1987559348 @default.
- W3181691036 cites W1999574084 @default.
- W3181691036 cites W2003336885 @default.
- W3181691036 cites W2003410399 @default.
- W3181691036 cites W2011930181 @default.
- W3181691036 cites W2012606399 @default.
- W3181691036 cites W2012616814 @default.
- W3181691036 cites W2020469828 @default.
- W3181691036 cites W2022908550 @default.
- W3181691036 cites W2024917635 @default.
- W3181691036 cites W2025740004 @default.
- W3181691036 cites W2028138492 @default.
- W3181691036 cites W2031703601 @default.
- W3181691036 cites W2032864658 @default.
- W3181691036 cites W2039436205 @default.
- W3181691036 cites W2040305049 @default.
- W3181691036 cites W2045949302 @default.
- W3181691036 cites W2047028501 @default.
- W3181691036 cites W2051052284 @default.
- W3181691036 cites W2055998713 @default.
- W3181691036 cites W2057951356 @default.
- W3181691036 cites W2059670143 @default.
- W3181691036 cites W2062682951 @default.
- W3181691036 cites W2074192627 @default.
- W3181691036 cites W2078253393 @default.
- W3181691036 cites W2082843411 @default.
- W3181691036 cites W2084566588 @default.
- W3181691036 cites W2086920741 @default.
- W3181691036 cites W2096035000 @default.
- W3181691036 cites W2096239313 @default.
- W3181691036 cites W2101504245 @default.
- W3181691036 cites W2106708530 @default.
- W3181691036 cites W2110579982 @default.
- W3181691036 cites W2111353279 @default.
- W3181691036 cites W2113249378 @default.
- W3181691036 cites W2115999215 @default.
- W3181691036 cites W2116634113 @default.
- W3181691036 cites W2119898992 @default.
- W3181691036 cites W2120218847 @default.
- W3181691036 cites W2122440289 @default.
- W3181691036 cites W2125910575 @default.
- W3181691036 cites W2128775004 @default.
- W3181691036 cites W2133082213 @default.
- W3181691036 cites W2133775329 @default.
- W3181691036 cites W2137499573 @default.
- W3181691036 cites W2143827549 @default.
- W3181691036 cites W2146267270 @default.
- W3181691036 cites W2146512944 @default.
- W3181691036 cites W2148708580 @default.
- W3181691036 cites W2159675211 @default.
- W3181691036 cites W2160749536 @default.
- W3181691036 cites W2166763675 @default.
- W3181691036 cites W2169353806 @default.
- W3181691036 cites W2169456326 @default.
- W3181691036 cites W2170989872 @default.
- W3181691036 cites W2197124664 @default.
- W3181691036 cites W2206699319 @default.
- W3181691036 cites W2252384906 @default.
- W3181691036 cites W2254540178 @default.
- W3181691036 cites W2271681808 @default.
- W3181691036 cites W2307837122 @default.
- W3181691036 cites W2347076456 @default.
- W3181691036 cites W2411185224 @default.
- W3181691036 cites W2485397215 @default.
- W3181691036 cites W2515584957 @default.
- W3181691036 cites W2518959324 @default.
- W3181691036 cites W2550922779 @default.
- W3181691036 cites W2559547969 @default.
- W3181691036 cites W2604498541 @default.
- W3181691036 cites W2613687023 @default.