Matches in SemOpenAlex for { <https://semopenalex.org/work/W3181724055> ?p ?o ?g. }
- W3181724055 endingPage "1451" @default.
- W3181724055 startingPage "1443" @default.
- W3181724055 abstract "Abstract Previous evidence suggests that sialic acid‐binding Ig‐like lectin 7 (Siglec‐7) protein is significantly increased in patients with chronic hepatitis C virus (HCV) infection and directly correlates with clinical parameters of liver inflammation and fibrosis. The aim of this study was to determine the diagnostic value of Siglec‐7 as a non‐invasive tool to assess liver fibrosis in patients with chronic hepatitis C in a cross‐sectional study. Serum levels of Siglec‐7 were retrospectively tested in 1007 consecutive patients with chronic HCV infection recruited at three different European sites and data examined by the ‘imperfect gold‐standard’ statistical analysis. Liver stiffness obtained by transient elastography (TE) was considered the standard reference. Liver fibrosis was staged according to published cut‐offs of liver stiffness measurement by TE. Accuracy of detection of liver fibrosis stage was not increased by Siglec‐7 alone. However, we developed a new index (SiGAP) including Siglec‐7, γ‐glutamyl transferase, age and platelet count which showed increased sensitivity and specificity in predicting fibrosis compared with APRI or FIB4 indices. The AUROC of SiGAP for the diagnosis of significant (≥F2) and advanced liver fibrosis (≥F3) showed significantly higher values than those of APRI and FIB‐4. Siglec‐7 may be useful as a complementary tool to assess liver fibrosis stage in patients with chronic hepatitis C when included in a specifically designed algorithm, which showed high level of accuracy in the detection of F2 and F3 fibrosis stage." @default.
- W3181724055 created "2021-07-19" @default.
- W3181724055 creator A5000669253 @default.
- W3181724055 creator A5004666438 @default.
- W3181724055 creator A5006030450 @default.
- W3181724055 creator A5018414791 @default.
- W3181724055 creator A5021556779 @default.
- W3181724055 creator A5028311121 @default.
- W3181724055 creator A5029464276 @default.
- W3181724055 creator A5031957769 @default.
- W3181724055 creator A5041843332 @default.
- W3181724055 creator A5055005038 @default.
- W3181724055 creator A5055319838 @default.
- W3181724055 creator A5063942905 @default.
- W3181724055 creator A5064069847 @default.
- W3181724055 creator A5074836130 @default.
- W3181724055 creator A5087499191 @default.
- W3181724055 date "2021-07-14" @default.
- W3181724055 modified "2023-10-17" @default.
- W3181724055 title "A new algorithm shows superior ability to discriminate liver fibrosis stages in chronic hepatitis C" @default.
- W3181724055 cites W1817934112 @default.
- W3181724055 cites W1966056248 @default.
- W3181724055 cites W1971991764 @default.
- W3181724055 cites W1977830305 @default.
- W3181724055 cites W1982484050 @default.
- W3181724055 cites W1987349835 @default.
- W3181724055 cites W1997865776 @default.
- W3181724055 cites W2000518846 @default.
- W3181724055 cites W2015536561 @default.
- W3181724055 cites W2031140200 @default.
- W3181724055 cites W2058203033 @default.
- W3181724055 cites W2061337758 @default.
- W3181724055 cites W2073870582 @default.
- W3181724055 cites W2083718019 @default.
- W3181724055 cites W2088337379 @default.
- W3181724055 cites W2095068170 @default.
- W3181724055 cites W2099184552 @default.
- W3181724055 cites W2114376411 @default.
- W3181724055 cites W2136336812 @default.
- W3181724055 cites W2153880482 @default.
- W3181724055 cites W216121951 @default.
- W3181724055 cites W2308604144 @default.
- W3181724055 cites W2318933482 @default.
- W3181724055 cites W2328176404 @default.
- W3181724055 cites W2363023549 @default.
- W3181724055 cites W2519498039 @default.
- W3181724055 cites W2523553952 @default.
- W3181724055 cites W2742099420 @default.
- W3181724055 cites W2754990893 @default.
- W3181724055 cites W2766070061 @default.
- W3181724055 cites W2782867353 @default.
- W3181724055 cites W2894758234 @default.
- W3181724055 cites W2898378712 @default.
- W3181724055 cites W2918873588 @default.
- W3181724055 cites W2950514720 @default.
- W3181724055 cites W2993404739 @default.
- W3181724055 cites W3127821066 @default.
- W3181724055 doi "https://doi.org/10.1111/jvh.13570" @default.
- W3181724055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34228858" @default.
- W3181724055 hasPublicationYear "2021" @default.
- W3181724055 type Work @default.
- W3181724055 sameAs 3181724055 @default.
- W3181724055 citedByCount "2" @default.
- W3181724055 countsByYear W31817240552023 @default.
- W3181724055 crossrefType "journal-article" @default.
- W3181724055 hasAuthorship W3181724055A5000669253 @default.
- W3181724055 hasAuthorship W3181724055A5004666438 @default.
- W3181724055 hasAuthorship W3181724055A5006030450 @default.
- W3181724055 hasAuthorship W3181724055A5018414791 @default.
- W3181724055 hasAuthorship W3181724055A5021556779 @default.
- W3181724055 hasAuthorship W3181724055A5028311121 @default.
- W3181724055 hasAuthorship W3181724055A5029464276 @default.
- W3181724055 hasAuthorship W3181724055A5031957769 @default.
- W3181724055 hasAuthorship W3181724055A5041843332 @default.
- W3181724055 hasAuthorship W3181724055A5055005038 @default.
- W3181724055 hasAuthorship W3181724055A5055319838 @default.
- W3181724055 hasAuthorship W3181724055A5063942905 @default.
- W3181724055 hasAuthorship W3181724055A5064069847 @default.
- W3181724055 hasAuthorship W3181724055A5074836130 @default.
- W3181724055 hasAuthorship W3181724055A5087499191 @default.
- W3181724055 hasConcept C11413529 @default.
- W3181724055 hasConcept C126322002 @default.
- W3181724055 hasConcept C146357865 @default.
- W3181724055 hasConcept C151730666 @default.
- W3181724055 hasConcept C203014093 @default.
- W3181724055 hasConcept C2522874641 @default.
- W3181724055 hasConcept C2776455275 @default.
- W3181724055 hasConcept C2780559512 @default.
- W3181724055 hasConcept C2780826214 @default.
- W3181724055 hasConcept C2994217296 @default.
- W3181724055 hasConcept C3020491458 @default.
- W3181724055 hasConcept C40993552 @default.
- W3181724055 hasConcept C41008148 @default.
- W3181724055 hasConcept C71924100 @default.
- W3181724055 hasConcept C86803240 @default.
- W3181724055 hasConcept C90924648 @default.
- W3181724055 hasConceptScore W3181724055C11413529 @default.
- W3181724055 hasConceptScore W3181724055C126322002 @default.