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- W3181853288 abstract "Objective: To investigate the dynamics of NSE during treatment of isoosmolar 0.9% NaCl solution and the hyperosmolar mannitol solution in acute ischemic stroke.Methods: It was studied 15 patients with acute ischemic stroke. The investigated isoosmolar 0.9% Nacl solution and the solution hyperosmolar mannitol administered intravenously in a conventionally effective dose (defined in the experiment) directly upon confirmation of the diagnosis of acute ischemic stroke and further every day, every 12 hours for 7 days. A control group were patients treated with infusion therapy only 0.9% NaCl solution, the comparison group were patients treated with 0.9% NaCl solution + mannitol. Blood sampling was conducted for determination of specific marker of cerebral ischemia the neuron-specific enolase (1st, 4th and 7th day of stroke).Results: Treatment of patients with acute ischemic stroke with mannitol was accompanied by the dynamic growth of the test marker of neurodestruction from 17 to 23 nm / ml in all periods of observation with a statistically significant increase in the activity of NSE on the seventh day of stroke. A similar picture is viewed in the group with 0.9% NaCl solution.Conclusion: infusion therapy with isoosmolar 0.9% NaCl solution + hyperosmolar mannitol with standard therapy was accompanied by a dynamic growth of NSE in patients with acute cerebrovascular accident on ischemic type as in the control group." @default.
- W3181853288 created "2021-07-19" @default.
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- W3181853288 date "2015-12-15" @default.
- W3181853288 modified "2023-10-18" @default.
- W3181853288 title "Effect of infusion solutions on the dynamics of neuronspecific enolase activity in patients with acute cerebral ischemia" @default.
- W3181853288 hasPublicationYear "2015" @default.
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