Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182019922> ?p ?o ?g. }
- W3182019922 abstract "Abstract Bacterial vaginosis (BV) is a gynecologic disorder characterized by a shift in cervicovaginal microbiota from Lactobacillus spp. dominance to a polymicrobial biofilm composed of diverse anaerobes. We utilized a well-characterized human three-dimensional cervical epithelial cell model in conjunction with untargeted metabolomics and immunoproteomics analyses to determine the immunometabolic contribution of three members of the Veillonellaceae family: Veillonella atypica , Veillonella montpellierensis and Megasphaera micronuciformis at this site. We found that Veillonella spp. infections induced significant elevation of polyamines. M. micronuciformis infections significantly increased soluble inflammatory mediators, induced moderate levels of cell cytotoxicity, and accumulation of cell membrane lipids relative to Veillonella spp. Notably, both V. atypica and V. montpellierensis infections resulted in consumption of lactate, a key metabolite linked to gynecologic and reproductive health. Collectively our approach and data provide unique insights into the specific contributions of Veillonellaceae members to the pathogenesis of BV and women’s health." @default.
- W3182019922 created "2021-07-19" @default.
- W3182019922 creator A5002269357 @default.
- W3182019922 creator A5009887131 @default.
- W3182019922 creator A5046024274 @default.
- W3182019922 creator A5051541375 @default.
- W3182019922 creator A5055170324 @default.
- W3182019922 date "2021-07-06" @default.
- W3182019922 modified "2023-10-14" @default.
- W3182019922 title "Veillonellaceae family members uniquely alter the cervical metabolic microenvironment in a human three-dimensional epithelial model" @default.
- W3182019922 cites W1491890181 @default.
- W3182019922 cites W1504061422 @default.
- W3182019922 cites W1517638146 @default.
- W3182019922 cites W1531888307 @default.
- W3182019922 cites W1544032451 @default.
- W3182019922 cites W1547082834 @default.
- W3182019922 cites W1548772785 @default.
- W3182019922 cites W1617495083 @default.
- W3182019922 cites W1754047185 @default.
- W3182019922 cites W179325632 @default.
- W3182019922 cites W1892509609 @default.
- W3182019922 cites W1908906771 @default.
- W3182019922 cites W1966918442 @default.
- W3182019922 cites W1968670250 @default.
- W3182019922 cites W1984227898 @default.
- W3182019922 cites W1985903545 @default.
- W3182019922 cites W1997805852 @default.
- W3182019922 cites W2010393163 @default.
- W3182019922 cites W2013553461 @default.
- W3182019922 cites W2014605450 @default.
- W3182019922 cites W2018420111 @default.
- W3182019922 cites W2021787227 @default.
- W3182019922 cites W2033063267 @default.
- W3182019922 cites W2041515539 @default.
- W3182019922 cites W2047740187 @default.
- W3182019922 cites W2048839739 @default.
- W3182019922 cites W2058124179 @default.
- W3182019922 cites W2061733438 @default.
- W3182019922 cites W2061774324 @default.
- W3182019922 cites W2062179619 @default.
- W3182019922 cites W2063756198 @default.
- W3182019922 cites W2070561614 @default.
- W3182019922 cites W2079095790 @default.
- W3182019922 cites W2079276179 @default.
- W3182019922 cites W2082992817 @default.
- W3182019922 cites W2097423946 @default.
- W3182019922 cites W2117943649 @default.
- W3182019922 cites W2127934824 @default.
- W3182019922 cites W2135679184 @default.
- W3182019922 cites W2136432779 @default.
- W3182019922 cites W2140174751 @default.
- W3182019922 cites W2154988722 @default.
- W3182019922 cites W2155185367 @default.
- W3182019922 cites W2158353135 @default.
- W3182019922 cites W2171843523 @default.
- W3182019922 cites W2171959793 @default.
- W3182019922 cites W2175259778 @default.
- W3182019922 cites W2308105260 @default.
- W3182019922 cites W2324832744 @default.
- W3182019922 cites W2476742596 @default.
- W3182019922 cites W2485188523 @default.
- W3182019922 cites W2498998695 @default.
- W3182019922 cites W2514590885 @default.
- W3182019922 cites W2599062916 @default.
- W3182019922 cites W2766612280 @default.
- W3182019922 cites W2789536221 @default.
- W3182019922 cites W2790162881 @default.
- W3182019922 cites W2806769319 @default.
- W3182019922 cites W2886254175 @default.
- W3182019922 cites W2887706592 @default.
- W3182019922 cites W2902487298 @default.
- W3182019922 cites W2904635536 @default.
- W3182019922 cites W2907800765 @default.
- W3182019922 cites W2941842978 @default.
- W3182019922 cites W2966771290 @default.
- W3182019922 cites W2970213122 @default.
- W3182019922 cites W2974361058 @default.
- W3182019922 cites W2977541623 @default.
- W3182019922 cites W2978671551 @default.
- W3182019922 cites W2990915312 @default.
- W3182019922 cites W2998715069 @default.
- W3182019922 cites W3000678207 @default.
- W3182019922 cites W3002359225 @default.
- W3182019922 cites W3007674389 @default.
- W3182019922 cites W3016625243 @default.
- W3182019922 cites W3040245690 @default.
- W3182019922 cites W3062702076 @default.
- W3182019922 cites W3097890239 @default.
- W3182019922 cites W3109953950 @default.
- W3182019922 doi "https://doi.org/10.1038/s41522-021-00229-0" @default.
- W3182019922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8260719" @default.
- W3182019922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34230496" @default.
- W3182019922 hasPublicationYear "2021" @default.
- W3182019922 type Work @default.
- W3182019922 sameAs 3182019922 @default.
- W3182019922 citedByCount "22" @default.
- W3182019922 countsByYear W31820199222021 @default.
- W3182019922 countsByYear W31820199222022 @default.
- W3182019922 countsByYear W31820199222023 @default.
- W3182019922 crossrefType "journal-article" @default.