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- W3182020075 endingPage "793" @default.
- W3182020075 startingPage "793" @default.
- W3182020075 abstract "Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is secreted mostly by hepatocytes and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells. PCSK9 has been known to interact with the low-density lipoprotein receptor (LDLR) and chaperones the receptor to its degradation. In this manner, targeting PCSK9 is a novel attractive approach to reduce hyperlipidaemia and the risk for cardiovascular diseases. Recently, it has been recognised that the effects of PCSK9 in relation to cardiovascular complications are not only LDLR related, but that various LDLR-independent pathways and processes are also influenced. In this review, the various LDLR dependent and especially independent effects of PCSK9 on the cardiovascular system are discussed, followed by an overview of related PCSK9-polymorphisms and currently available and future therapeutic approaches to manipulate PCSK9 expression." @default.
- W3182020075 created "2021-07-19" @default.
- W3182020075 creator A5007641943 @default.
- W3182020075 creator A5025368031 @default.
- W3182020075 creator A5063726355 @default.
- W3182020075 date "2021-07-08" @default.
- W3182020075 modified "2023-10-10" @default.
- W3182020075 title "PCSK9: A Multi-Faceted Protein That Is Involved in Cardiovascular Biology" @default.
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