Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182029025> ?p ?o ?g. }
- W3182029025 endingPage "321" @default.
- W3182029025 startingPage "312" @default.
- W3182029025 abstract "The rate of growth of primary melanoma is a robust predictor of aggressiveness, but the mutational profile of fast-growing melanomas (FGMM) and the potential to stratify patients at high risk of death has not been comprehensively studied.To investigate the epidemiologic, clinical, and mutational profile of primary cutaneous melanomas with a thickness ≥ 1 mm, stratified by rate of growth.Observational prospective study. Deep-targeted sequencing of 40 melanoma driver genes on formalin fixed, paraffin-embedded primary melanoma samples. Comparison of FGMM (rate of growth > 0.5 mm/month) and nonFGMM (rate of growth ≤ 0.5 mm/month).Two hundred patients were enrolled, among wom 70 had FGMM. The relapse-free survival was lower in the FGMM group (P = .014). FGMM had a higher number of predicted deleterious mutations within the 40 genes than nonFGMM (P = .033). Ulceration (P = .032), thickness (P = .006), lower sun exposure (P = .049), and fibroblast growth factor receptor 2 (FGFR2) mutations (P = .037) were significantly associated with fast growth.Single-center study, cohort size, potential memory bias, number of investigated genes.Fast growth is linked to specific tumor biology and environmental factors. Ulceration, thickness, and FGFR2 mutations are associated with fast growth. Screening for FGFR2 mutations might provide an additional tool to better identify FGMM, which are probably good candidates for adjuvant therapies." @default.
- W3182029025 created "2021-07-19" @default.
- W3182029025 creator A5010448208 @default.
- W3182029025 creator A5012668221 @default.
- W3182029025 creator A5015738864 @default.
- W3182029025 creator A5034361538 @default.
- W3182029025 creator A5036634814 @default.
- W3182029025 creator A5040001354 @default.
- W3182029025 creator A5042834885 @default.
- W3182029025 creator A5045881672 @default.
- W3182029025 creator A5054289982 @default.
- W3182029025 creator A5059637661 @default.
- W3182029025 creator A5061072132 @default.
- W3182029025 creator A5065248608 @default.
- W3182029025 creator A5069648259 @default.
- W3182029025 creator A5079795208 @default.
- W3182029025 creator A5082910742 @default.
- W3182029025 creator A5088690848 @default.
- W3182029025 date "2022-02-01" @default.
- W3182029025 modified "2023-10-14" @default.
- W3182029025 title "Molecular characterization of fast-growing melanomas" @default.
- W3182029025 cites W1950829641 @default.
- W3182029025 cites W1964226278 @default.
- W3182029025 cites W1983079102 @default.
- W3182029025 cites W1988476050 @default.
- W3182029025 cites W2001258296 @default.
- W3182029025 cites W2021580640 @default.
- W3182029025 cites W2029746613 @default.
- W3182029025 cites W2046786765 @default.
- W3182029025 cites W2068738245 @default.
- W3182029025 cites W2073852133 @default.
- W3182029025 cites W2074200851 @default.
- W3182029025 cites W2074893137 @default.
- W3182029025 cites W2080452140 @default.
- W3182029025 cites W2094889302 @default.
- W3182029025 cites W2096575630 @default.
- W3182029025 cites W2098475024 @default.
- W3182029025 cites W2108475180 @default.
- W3182029025 cites W2108939654 @default.
- W3182029025 cites W2114843025 @default.
- W3182029025 cites W2118863192 @default.
- W3182029025 cites W2130410032 @default.
- W3182029025 cites W2139046059 @default.
- W3182029025 cites W2149441684 @default.
- W3182029025 cites W2154758108 @default.
- W3182029025 cites W2156333450 @default.
- W3182029025 cites W2169612228 @default.
- W3182029025 cites W2179500290 @default.
- W3182029025 cites W2220812108 @default.
- W3182029025 cites W2284583894 @default.
- W3182029025 cites W2312662599 @default.
- W3182029025 cites W2319678007 @default.
- W3182029025 cites W2332292689 @default.
- W3182029025 cites W2537440061 @default.
- W3182029025 cites W2552082190 @default.
- W3182029025 cites W2560709085 @default.
- W3182029025 cites W2611222875 @default.
- W3182029025 cites W2762347490 @default.
- W3182029025 cites W2788324337 @default.
- W3182029025 cites W2898789672 @default.
- W3182029025 cites W2899454087 @default.
- W3182029025 cites W2901987494 @default.
- W3182029025 cites W2903686115 @default.
- W3182029025 cites W2949857618 @default.
- W3182029025 cites W3134688004 @default.
- W3182029025 doi "https://doi.org/10.1016/j.jaad.2021.07.011" @default.
- W3182029025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34280484" @default.
- W3182029025 hasPublicationYear "2022" @default.
- W3182029025 type Work @default.
- W3182029025 sameAs 3182029025 @default.
- W3182029025 citedByCount "11" @default.
- W3182029025 countsByYear W31820290252021 @default.
- W3182029025 countsByYear W31820290252022 @default.
- W3182029025 countsByYear W31820290252023 @default.
- W3182029025 crossrefType "journal-article" @default.
- W3182029025 hasAuthorship W3182029025A5010448208 @default.
- W3182029025 hasAuthorship W3182029025A5012668221 @default.
- W3182029025 hasAuthorship W3182029025A5015738864 @default.
- W3182029025 hasAuthorship W3182029025A5034361538 @default.
- W3182029025 hasAuthorship W3182029025A5036634814 @default.
- W3182029025 hasAuthorship W3182029025A5040001354 @default.
- W3182029025 hasAuthorship W3182029025A5042834885 @default.
- W3182029025 hasAuthorship W3182029025A5045881672 @default.
- W3182029025 hasAuthorship W3182029025A5054289982 @default.
- W3182029025 hasAuthorship W3182029025A5059637661 @default.
- W3182029025 hasAuthorship W3182029025A5061072132 @default.
- W3182029025 hasAuthorship W3182029025A5065248608 @default.
- W3182029025 hasAuthorship W3182029025A5069648259 @default.
- W3182029025 hasAuthorship W3182029025A5079795208 @default.
- W3182029025 hasAuthorship W3182029025A5082910742 @default.
- W3182029025 hasAuthorship W3182029025A5088690848 @default.
- W3182029025 hasConcept C104317684 @default.
- W3182029025 hasConcept C126322002 @default.
- W3182029025 hasConcept C143998085 @default.
- W3182029025 hasConcept C170493617 @default.
- W3182029025 hasConcept C2777658100 @default.
- W3182029025 hasConcept C50044444 @default.
- W3182029025 hasConcept C501734568 @default.