FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182036049> ?p ?o ?g. }

• W3182036049 endingPage "148775" @default.
• W3182036049 startingPage "148775" @default.
• W3182036049 abstract "Sodium ρ-perfluorous nonenoxybenzene sulfonate (OBS), a novel kind of perfluoroalkyl and polyfluoroalkyl compound, has been widely detected in the environment. The toxicity of OBS to living organisms has become a public concern. A growing body of research showed that maternal exposure to environmental pollutants caused intestinal and metabolic diseases that could be conserved across offspring. Here, female C57BL/6 mice were treated OBS at dietary levels of 0.0 mg/L (CON), 0.5 mg/L (OBS-L) and 5.0 mg/L (OBS-H) during the gestation and lactation periods. The results demonstrated that OBS treatment not only induced significant changes in the mucus secretion and ionic transport, but also disrupted the expression of antimicrobial peptides (AMPs) in the intestine of F0 and F1 generations. Additionally, OBS exposure altered bile acids metabolism and affected the transcriptional levels of critical genes involved in bile acids synthesis, signaling transfer, transportation and apical uptake. Together, all these results indicated that OBS exposure was perceived as a major stress by the intestinal epithelium that strongly affected the intestinal barrier function (including mucus, CFTR, AMPs, inflammation), and ultimately led to imbalance in the metabolism of bile acids (BAs). Moreover, we found that maternal OBS exposure had a more obvious toxicity effect on the male offspring in this experiment. Taken together, maternal OBS exposure during pregnancy and lactation had the intestinal and metabolism toxic effects on the dams and offspring, indicating that effects of maternal exposure on the toxicity of offspring could not be ignored. • OBS accumulated in serum and gut of dams and pups after maternal exposure during the pregnancy and lactation. • Maternal OBS exposure could disturb intestinal barrier and further affect intestinal homeostasis of dams and offspring. • Maternal OBS exposure disturbed the hepatic BAs metabolism in dams and offspring and there are gender differences." @default.
• W3182036049 created "2021-07-19" @default.
• W3182036049 creator A5003214586 @default.
• W3182036049 creator A5020372758 @default.
• W3182036049 creator A5023321792 @default.
• W3182036049 creator A5029180269 @default.
• W3182036049 creator A5065896300 @default.
• W3182036049 date "2021-11-01" @default.
• W3182036049 modified "2023-09-24" @default.
• W3182036049 title "Maternal exposure to sodium ρ-perfluorous nonenoxybenzene sulfonate during pregnancy and lactation disrupts intestinal barrier and may cause obstacles to the nutrient transport and metabolism in F0 and F1 generations of mice" @default.
• W3182036049 cites W1599484575 @default.
• W3182036049 cites W1966514588 @default.
• W3182036049 cites W1974616640 @default.
• W3182036049 cites W1976611079 @default.
• W3182036049 cites W2007497599 @default.
• W3182036049 cites W2011337131 @default.
• W3182036049 cites W2014579455 @default.
• W3182036049 cites W2031743395 @default.
• W3182036049 cites W2075414439 @default.
• W3182036049 cites W2077590888 @default.
• W3182036049 cites W2078284700 @default.
• W3182036049 cites W2082732215 @default.
• W3182036049 cites W2087577664 @default.
• W3182036049 cites W2088788142 @default.
• W3182036049 cites W2090278017 @default.
• W3182036049 cites W2097136349 @default.
• W3182036049 cites W2111493612 @default.
• W3182036049 cites W2139008734 @default.
• W3182036049 cites W2143844722 @default.
• W3182036049 cites W2151396872 @default.
• W3182036049 cites W2165677144 @default.
• W3182036049 cites W2167567374 @default.
• W3182036049 cites W2169002310 @default.
• W3182036049 cites W2195770199 @default.
• W3182036049 cites W2250981334 @default.
• W3182036049 cites W2322346801 @default.
• W3182036049 cites W2344977507 @default.
• W3182036049 cites W2487359925 @default.
• W3182036049 cites W2550313850 @default.
• W3182036049 cites W2552151087 @default.
• W3182036049 cites W2556245433 @default.
• W3182036049 cites W2763917533 @default.
• W3182036049 cites W2771170274 @default.
• W3182036049 cites W2808238760 @default.
• W3182036049 cites W2889479406 @default.
• W3182036049 cites W2894219029 @default.
• W3182036049 cites W2906108241 @default.
• W3182036049 cites W2935676311 @default.
• W3182036049 cites W2947605419 @default.
• W3182036049 cites W2950737242 @default.
• W3182036049 cites W2961208466 @default.
• W3182036049 cites W2971287896 @default.
• W3182036049 cites W2973106217 @default.
• W3182036049 cites W2980884117 @default.
• W3182036049 cites W2990182987 @default.
• W3182036049 cites W3004827378 @default.
• W3182036049 cites W3047921304 @default.
• W3182036049 cites W3048004680 @default.
• W3182036049 cites W3086885273 @default.
• W3182036049 cites W3096650643 @default.
• W3182036049 cites W3110567614 @default.
• W3182036049 cites W3128356673 @default.
• W3182036049 cites W3131088459 @default.
• W3182036049 cites W3160607840 @default.
• W3182036049 doi "https://doi.org/10.1016/j.scitotenv.2021.148775" @default.
• W3182036049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34323766" @default.
• W3182036049 hasPublicationYear "2021" @default.
• W3182036049 type Work @default.
• W3182036049 sameAs 3182036049 @default.
• W3182036049 citedByCount "5" @default.
• W3182036049 countsByYear W31820360492022 @default.
• W3182036049 countsByYear W31820360492023 @default.
• W3182036049 crossrefType "journal-article" @default.
• W3182036049 hasAuthorship W3182036049A5003214586 @default.
• W3182036049 hasAuthorship W3182036049A5020372758 @default.
• W3182036049 hasAuthorship W3182036049A5023321792 @default.
• W3182036049 hasAuthorship W3182036049A5029180269 @default.
• W3182036049 hasAuthorship W3182036049A5065896300 @default.
• W3182036049 hasConcept C112672928 @default.
• W3182036049 hasConcept C126322002 @default.
• W3182036049 hasConcept C134018914 @default.
• W3182036049 hasConcept C18903297 @default.
• W3182036049 hasConcept C2776659692 @default.
• W3182036049 hasConcept C2777312293 @default.
• W3182036049 hasConcept C2779234561 @default.
• W3182036049 hasConcept C29730261 @default.
• W3182036049 hasConcept C54355233 @default.
• W3182036049 hasConcept C62231903 @default.
• W3182036049 hasConcept C71924100 @default.
• W3182036049 hasConcept C86803240 @default.
• W3182036049 hasConceptScore W3182036049C112672928 @default.
• W3182036049 hasConceptScore W3182036049C126322002 @default.
• W3182036049 hasConceptScore W3182036049C134018914 @default.
• W3182036049 hasConceptScore W3182036049C18903297 @default.
• W3182036049 hasConceptScore W3182036049C2776659692 @default.
• W3182036049 hasConceptScore W3182036049C2777312293 @default.
• W3182036049 hasConceptScore W3182036049C2779234561 @default.
• W3182036049 hasConceptScore W3182036049C29730261 @default.

• next