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- W3182044385 abstract "More than 50% of proteinogenic amino acid sidechains can bind metal ions, enabling proteins and peptides to bear these ions as cofactors. Nevertheless, post-translational modifications and incorporation of noncanonical amino acids bestow peptides and proteins myriads of other coordination capabilities, thanks to an enhanced metal binding. Here we summarize selected examples of natural and artificial systems that contain one or more noncanonical amino acids coordinating a metal ion and subsequently achieve a new or enhanced function. We report on a wide array of systems: from disease-related proteins that undergo sulfurylation or phosphorylation through natural metallophores that selectively capture precious essential ions to synthetic selfassembly strategies, biocatalysts, and chelating agents against toxic metals. Regardless of their (bio)synthetic routes, all possess unique metal-binding properties that could not be effectively achieved by systems composed of canonical residues." @default.
- W3182044385 created "2021-07-19" @default.
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- W3182044385 date "2021-06-30" @default.
- W3182044385 modified "2023-10-16" @default.
- W3182044385 title "Enhancing Metal-binding with Noncanonical Coordinating Amino Acids" @default.
- W3182044385 doi "https://doi.org/10.2533/chimia.2021.530" @default.
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