FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182045589> ?p ?o ?g. }

• W3182045589 abstract "The present study aimed to investigate the effects of TGF‑β1, tissue inhibitor of metalloproteinase (TIMP)‑1 small interfering (si)RNA and TIMP‑2 siRNA on hepatic fibrosis in rats and explore the T helper (Th)1/Th2 balance. Moreover, IFN‑γ, IL‑4 and IL‑13 are the main cytokines associated with Th1/Th2 responses and have significant influence on the progression of hepatic fibrosis. The expression levels of IFN‑γ, IL‑4 and IL‑13 in rats with hepatic fibrosis that were treated with siRNAs against the aforementioned molecules were measured using various techniques including immunohistochemical staining, western blotting and reverse transcription‑quantitative PCR. The principal outcomes revealed the downregulation of IFN‑γ and the upregulation of IL‑4 and IL‑13 in the model group compared with the normal group. Moreover, the expression of IFN‑γ was significantly increased, while IL‑4 and IL‑13 demonstrated no significant difference in the TGF‑β1 siRNA treatment group compared with the model group. The TIMP‑1 and TIMP‑2 siRNA treatment groups exhibited significantly increased expression levels of IFN‑γ, but lower expression levels of IL‑4 and IL‑13 compared with the model group. These results indicated that TIMP‑1 and TIMP‑2 were improved antifibrotic targets compared with TGF‑β1." @default.
• W3182045589 created "2021-07-19" @default.
• W3182045589 creator A5040459032 @default.
• W3182045589 creator A5048369268 @default.
• W3182045589 creator A5054764710 @default.
• W3182045589 creator A5060969271 @default.
• W3182045589 creator A5065838737 @default.
• W3182045589 date "2021-07-07" @default.
• W3182045589 modified "2023-10-10" @default.
• W3182045589 title "Application of TGF‑β1, TIMP‑1 and TIMP‑2 small interfering RNAs can alleviate CCl₄‑induced hepatic fibrosis in rats by rebalancing Th1/Th2 cytokines" @default.
• W3182045589 cites W1935205446 @default.
• W3182045589 cites W1981469294 @default.
• W3182045589 cites W1983357763 @default.
• W3182045589 cites W2002364801 @default.
• W3182045589 cites W2004697163 @default.
• W3182045589 cites W2028527478 @default.
• W3182045589 cites W2030187502 @default.
• W3182045589 cites W2071799721 @default.
• W3182045589 cites W2107277218 @default.
• W3182045589 cites W2145317632 @default.
• W3182045589 cites W2149183432 @default.
• W3182045589 cites W2412061250 @default.
• W3182045589 cites W2417406464 @default.
• W3182045589 cites W2517275682 @default.
• W3182045589 cites W2588964480 @default.
• W3182045589 cites W2613180696 @default.
• W3182045589 cites W2679520842 @default.
• W3182045589 cites W2790513179 @default.
• W3182045589 cites W2811001233 @default.
• W3182045589 cites W2905700866 @default.
• W3182045589 cites W2939241979 @default.
• W3182045589 cites W3033040231 @default.
• W3182045589 cites W3092993367 @default.
• W3182045589 cites W3140110505 @default.
• W3182045589 doi "https://doi.org/10.3892/etm.2021.10395" @default.
• W3182045589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8290469" @default.
• W3182045589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34335905" @default.
• W3182045589 hasPublicationYear "2021" @default.
• W3182045589 type Work @default.
• W3182045589 sameAs 3182045589 @default.
• W3182045589 citedByCount "5" @default.
• W3182045589 countsByYear W31820455892022 @default.
• W3182045589 countsByYear W31820455892023 @default.
• W3182045589 crossrefType "journal-article" @default.
• W3182045589 hasAuthorship W3182045589A5040459032 @default.
• W3182045589 hasAuthorship W3182045589A5048369268 @default.
• W3182045589 hasAuthorship W3182045589A5054764710 @default.
• W3182045589 hasAuthorship W3182045589A5060969271 @default.
• W3182045589 hasAuthorship W3182045589A5065838737 @default.
• W3182045589 hasBestOaLocation W31820455891 @default.
• W3182045589 hasConcept C104317684 @default.
• W3182045589 hasConcept C118131993 @default.
• W3182045589 hasConcept C121608353 @default.
• W3182045589 hasConcept C126322002 @default.
• W3182045589 hasConcept C127561419 @default.
• W3182045589 hasConcept C164027704 @default.
• W3182045589 hasConcept C176891718 @default.
• W3182045589 hasConcept C203014093 @default.
• W3182045589 hasConcept C204232928 @default.
• W3182045589 hasConcept C22615655 @default.
• W3182045589 hasConcept C2776914184 @default.
• W3182045589 hasConcept C2780559512 @default.
• W3182045589 hasConcept C2781018059 @default.
• W3182045589 hasConcept C29537977 @default.
• W3182045589 hasConcept C2993667909 @default.
• W3182045589 hasConcept C502942594 @default.
• W3182045589 hasConcept C55493867 @default.
• W3182045589 hasConcept C67082663 @default.
• W3182045589 hasConcept C67705224 @default.
• W3182045589 hasConcept C71924100 @default.
• W3182045589 hasConcept C85265743 @default.
• W3182045589 hasConcept C86803240 @default.
• W3182045589 hasConceptScore W3182045589C104317684 @default.
• W3182045589 hasConceptScore W3182045589C118131993 @default.
• W3182045589 hasConceptScore W3182045589C121608353 @default.
• W3182045589 hasConceptScore W3182045589C126322002 @default.
• W3182045589 hasConceptScore W3182045589C127561419 @default.
• W3182045589 hasConceptScore W3182045589C164027704 @default.
• W3182045589 hasConceptScore W3182045589C176891718 @default.
• W3182045589 hasConceptScore W3182045589C203014093 @default.
• W3182045589 hasConceptScore W3182045589C204232928 @default.
• W3182045589 hasConceptScore W3182045589C22615655 @default.
• W3182045589 hasConceptScore W3182045589C2776914184 @default.
• W3182045589 hasConceptScore W3182045589C2780559512 @default.
• W3182045589 hasConceptScore W3182045589C2781018059 @default.
• W3182045589 hasConceptScore W3182045589C29537977 @default.
• W3182045589 hasConceptScore W3182045589C2993667909 @default.
• W3182045589 hasConceptScore W3182045589C502942594 @default.
• W3182045589 hasConceptScore W3182045589C55493867 @default.
• W3182045589 hasConceptScore W3182045589C67082663 @default.
• W3182045589 hasConceptScore W3182045589C67705224 @default.
• W3182045589 hasConceptScore W3182045589C71924100 @default.
• W3182045589 hasConceptScore W3182045589C85265743 @default.
• W3182045589 hasConceptScore W3182045589C86803240 @default.
• W3182045589 hasIssue "3" @default.
• W3182045589 hasLocation W31820455891 @default.
• W3182045589 hasLocation W31820455892 @default.
• W3182045589 hasOpenAccess W3182045589 @default.
• W3182045589 hasPrimaryLocation W31820455891 @default.
• W3182045589 hasRelatedWork W2023126270 @default.

• next