Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182045910> ?p ?o ?g. }
- W3182045910 endingPage "10966" @default.
- W3182045910 startingPage "10951" @default.
- W3182045910 abstract "Influenza viruses cause approximately half a million deaths every year worldwide. Vaccines are available but partially effective, and the number of antiviral medications is limited. Thus, it is crucial to develop therapeutic strategies to counteract this major pathogen. Influenza viruses enter the host cell via their hemagglutinin (HA) proteins. The HA subtypes of influenza A virus are phylogenetically classified into groups 1 and 2. Here, we identified an inhibitor of the HA protein, a tertiary aryl sulfonamide, that prevents influenza virus entry and replication. This compound shows potent antiviral activity against diverse H1N1, H5N1, and H3N2 influenza viruses encoding HA proteins from both groups 1 and 2. Synthesis of derivatives of this aryl sulfonamide identified moieties important for antiviral activity. This compound may be considered as a lead for drug development with the intent to be used alone or in combination with other influenza A virus antivirals to enhance pan-subtype efficacy." @default.
- W3182045910 created "2021-07-19" @default.
- W3182045910 creator A5004889712 @default.
- W3182045910 creator A5005490552 @default.
- W3182045910 creator A5005522829 @default.
- W3182045910 creator A5008874854 @default.
- W3182045910 creator A5014882971 @default.
- W3182045910 creator A5025447182 @default.
- W3182045910 creator A5041400773 @default.
- W3182045910 creator A5042166531 @default.
- W3182045910 creator A5045374495 @default.
- W3182045910 creator A5056347853 @default.
- W3182045910 creator A5069578805 @default.
- W3182045910 creator A5081012778 @default.
- W3182045910 creator A5085844933 @default.
- W3182045910 creator A5088196532 @default.
- W3182045910 date "2021-07-14" @default.
- W3182045910 modified "2023-10-18" @default.
- W3182045910 title "Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein" @default.
- W3182045910 cites W1970801348 @default.
- W3182045910 cites W1984700526 @default.
- W3182045910 cites W1990437594 @default.
- W3182045910 cites W1994615479 @default.
- W3182045910 cites W2016677998 @default.
- W3182045910 cites W2033122170 @default.
- W3182045910 cites W2037115572 @default.
- W3182045910 cites W2048381160 @default.
- W3182045910 cites W2071412733 @default.
- W3182045910 cites W2079337999 @default.
- W3182045910 cites W2096091144 @default.
- W3182045910 cites W2096148788 @default.
- W3182045910 cites W2096495877 @default.
- W3182045910 cites W2106622743 @default.
- W3182045910 cites W2110097995 @default.
- W3182045910 cites W2128025490 @default.
- W3182045910 cites W2153074293 @default.
- W3182045910 cites W2154102997 @default.
- W3182045910 cites W2159734253 @default.
- W3182045910 cites W2191641478 @default.
- W3182045910 cites W2408181412 @default.
- W3182045910 cites W2773743563 @default.
- W3182045910 cites W2775569101 @default.
- W3182045910 cites W2921235572 @default.
- W3182045910 cites W2989876636 @default.
- W3182045910 cites W3008005588 @default.
- W3182045910 cites W3011613799 @default.
- W3182045910 cites W3014760370 @default.
- W3182045910 cites W3043559273 @default.
- W3182045910 cites W38265209 @default.
- W3182045910 doi "https://doi.org/10.1021/acs.jmedchem.1c00304" @default.
- W3182045910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34260245" @default.
- W3182045910 hasPublicationYear "2021" @default.
- W3182045910 type Work @default.
- W3182045910 sameAs 3182045910 @default.
- W3182045910 citedByCount "7" @default.
- W3182045910 countsByYear W31820459102021 @default.
- W3182045910 countsByYear W31820459102022 @default.
- W3182045910 countsByYear W31820459102023 @default.
- W3182045910 crossrefType "journal-article" @default.
- W3182045910 hasAuthorship W3182045910A5004889712 @default.
- W3182045910 hasAuthorship W3182045910A5005490552 @default.
- W3182045910 hasAuthorship W3182045910A5005522829 @default.
- W3182045910 hasAuthorship W3182045910A5008874854 @default.
- W3182045910 hasAuthorship W3182045910A5014882971 @default.
- W3182045910 hasAuthorship W3182045910A5025447182 @default.
- W3182045910 hasAuthorship W3182045910A5041400773 @default.
- W3182045910 hasAuthorship W3182045910A5042166531 @default.
- W3182045910 hasAuthorship W3182045910A5045374495 @default.
- W3182045910 hasAuthorship W3182045910A5056347853 @default.
- W3182045910 hasAuthorship W3182045910A5069578805 @default.
- W3182045910 hasAuthorship W3182045910A5081012778 @default.
- W3182045910 hasAuthorship W3182045910A5085844933 @default.
- W3182045910 hasAuthorship W3182045910A5088196532 @default.
- W3182045910 hasBestOaLocation W31820459102 @default.
- W3182045910 hasConcept C140704245 @default.
- W3182045910 hasConcept C159047783 @default.
- W3182045910 hasConcept C185592680 @default.
- W3182045910 hasConcept C2522874641 @default.
- W3182045910 hasConcept C2777546802 @default.
- W3182045910 hasConcept C2778692840 @default.
- W3182045910 hasConcept C2779756493 @default.
- W3182045910 hasConcept C2781039511 @default.
- W3182045910 hasConcept C519248777 @default.
- W3182045910 hasConcept C68434959 @default.
- W3182045910 hasConcept C71240020 @default.
- W3182045910 hasConcept C86803240 @default.
- W3182045910 hasConcept C89423630 @default.
- W3182045910 hasConceptScore W3182045910C140704245 @default.
- W3182045910 hasConceptScore W3182045910C159047783 @default.
- W3182045910 hasConceptScore W3182045910C185592680 @default.
- W3182045910 hasConceptScore W3182045910C2522874641 @default.
- W3182045910 hasConceptScore W3182045910C2777546802 @default.
- W3182045910 hasConceptScore W3182045910C2778692840 @default.
- W3182045910 hasConceptScore W3182045910C2779756493 @default.
- W3182045910 hasConceptScore W3182045910C2781039511 @default.
- W3182045910 hasConceptScore W3182045910C519248777 @default.
- W3182045910 hasConceptScore W3182045910C68434959 @default.
- W3182045910 hasConceptScore W3182045910C71240020 @default.