Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182116764> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W3182116764 endingPage "489" @default.
- W3182116764 startingPage "489" @default.
- W3182116764 abstract "Numerous members of the human G protein-coupled receptor (GPCR) superfamily are receptors of therapeutic interest. GPCRs are considered to be highly tractable for drug discovery, representing the targets of approximately one-third of currently licensed drugs. These successful drug discovery outcomes cover only a relatively small subset of the superfamily, however, and many other attractive receptors have proven to present significant challenges. Among these difficult GPCRs are those whose natural ligands are peptides and proteins. In this review we explain the obstacles faced by GPCR drug discovery campaigns, with particular focus on those related to peptide and protein GPCRs. We describe a novel and promising approach for these targets based on engineering of their natural ligands and describe an integrated discovery platform that allows potent ligand analogs to be discovered rapidly and efficiently. Finally, we present a case study involving the chemokine receptor CCR5 to show that this approach can be used to generate new drugs for peptide and protein GPCR targets combining best-in-class potency with tunable signaling activity." @default.
- W3182116764 created "2021-07-19" @default.
- W3182116764 creator A5020288455 @default.
- W3182116764 creator A5033345778 @default.
- W3182116764 creator A5082234525 @default.
- W3182116764 date "2021-06-30" @default.
- W3182116764 modified "2023-10-16" @default.
- W3182116764 title "Precision-engineered Peptide and Protein Analogs: Establishing a New Discovery Platform for Potent GPCR Modulators" @default.
- W3182116764 doi "https://doi.org/10.2533/chimia.2021.489" @default.
- W3182116764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34233810" @default.
- W3182116764 hasPublicationYear "2021" @default.
- W3182116764 type Work @default.
- W3182116764 sameAs 3182116764 @default.
- W3182116764 citedByCount "2" @default.
- W3182116764 countsByYear W31821167642022 @default.
- W3182116764 crossrefType "journal-article" @default.
- W3182116764 hasAuthorship W3182116764A5020288455 @default.
- W3182116764 hasAuthorship W3182116764A5033345778 @default.
- W3182116764 hasAuthorship W3182116764A5082234525 @default.
- W3182116764 hasBestOaLocation W31821167641 @default.
- W3182116764 hasConcept C12823836 @default.
- W3182116764 hasConcept C13373296 @default.
- W3182116764 hasConcept C135285700 @default.
- W3182116764 hasConcept C170493617 @default.
- W3182116764 hasConcept C2779281246 @default.
- W3182116764 hasConcept C55493867 @default.
- W3182116764 hasConcept C60644358 @default.
- W3182116764 hasConcept C70721500 @default.
- W3182116764 hasConcept C74187038 @default.
- W3182116764 hasConcept C86803240 @default.
- W3182116764 hasConcept C92028520 @default.
- W3182116764 hasConceptScore W3182116764C12823836 @default.
- W3182116764 hasConceptScore W3182116764C13373296 @default.
- W3182116764 hasConceptScore W3182116764C135285700 @default.
- W3182116764 hasConceptScore W3182116764C170493617 @default.
- W3182116764 hasConceptScore W3182116764C2779281246 @default.
- W3182116764 hasConceptScore W3182116764C55493867 @default.
- W3182116764 hasConceptScore W3182116764C60644358 @default.
- W3182116764 hasConceptScore W3182116764C70721500 @default.
- W3182116764 hasConceptScore W3182116764C74187038 @default.
- W3182116764 hasConceptScore W3182116764C86803240 @default.
- W3182116764 hasConceptScore W3182116764C92028520 @default.
- W3182116764 hasIssue "6" @default.
- W3182116764 hasLocation W31821167641 @default.
- W3182116764 hasLocation W31821167642 @default.
- W3182116764 hasOpenAccess W3182116764 @default.
- W3182116764 hasPrimaryLocation W31821167641 @default.
- W3182116764 hasRelatedWork W12379937 @default.
- W3182116764 hasRelatedWork W1979486486 @default.
- W3182116764 hasRelatedWork W2073812411 @default.
- W3182116764 hasRelatedWork W2150984290 @default.
- W3182116764 hasRelatedWork W2412072550 @default.
- W3182116764 hasRelatedWork W2618932375 @default.
- W3182116764 hasRelatedWork W2944441714 @default.
- W3182116764 hasRelatedWork W3091107267 @default.
- W3182116764 hasRelatedWork W3182116764 @default.
- W3182116764 hasRelatedWork W76298398 @default.
- W3182116764 hasVolume "75" @default.
- W3182116764 isParatext "false" @default.
- W3182116764 isRetracted "false" @default.
- W3182116764 magId "3182116764" @default.
- W3182116764 workType "article" @default.