Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182181875> ?p ?o ?g. }
- W3182181875 abstract "Abstract Platelet transfusions are an integral component of balanced hemostatic resuscitation protocols used to manage severe hemorrhage following trauma. Enhancing the hemostatic potential of platelets could lead to further increases in the efficacy of transfusions, particularly for non‐compressible torso hemorrhage or severe hemorrhage with coagulopathy, by decreasing blood loss and improving overall patient outcomes. Advances in gene therapies, including RNA therapies, are leading to new strategies to enhance platelets for better control of hemorrhage. This review will highlight three approaches for creating modified platelets using gene therapies: (i) direct transfection of transfusable platelets ex vivo, (ii) in vitro production of engineered platelets from platelet‐precursor cells, and (iii) modifying the bone marrow for in vivo production of modified platelets. In summary, modifying platelets to enhance their hemostatic potential is an exciting new frontier in transfusion medicine, but more preclinical development as well as studies testing the safety and efficacy of these agents are needed." @default.
- W3182181875 created "2021-07-19" @default.
- W3182181875 creator A5001849498 @default.
- W3182181875 creator A5025987092 @default.
- W3182181875 creator A5071703309 @default.
- W3182181875 date "2021-07-01" @default.
- W3182181875 modified "2023-09-26" @default.
- W3182181875 title "Emerging gene therapies for enhancing the hemostatic potential of platelets" @default.
- W3182181875 cites W1510414151 @default.
- W3182181875 cites W1529566020 @default.
- W3182181875 cites W16089093 @default.
- W3182181875 cites W1921625623 @default.
- W3182181875 cites W1964548815 @default.
- W3182181875 cites W1964549099 @default.
- W3182181875 cites W1968287882 @default.
- W3182181875 cites W1970569414 @default.
- W3182181875 cites W1971402588 @default.
- W3182181875 cites W1979626640 @default.
- W3182181875 cites W1982376182 @default.
- W3182181875 cites W2000558617 @default.
- W3182181875 cites W2000912956 @default.
- W3182181875 cites W2008004245 @default.
- W3182181875 cites W2025303399 @default.
- W3182181875 cites W2025877828 @default.
- W3182181875 cites W2030809178 @default.
- W3182181875 cites W2039928766 @default.
- W3182181875 cites W2043167315 @default.
- W3182181875 cites W2050094423 @default.
- W3182181875 cites W2053776926 @default.
- W3182181875 cites W2054541525 @default.
- W3182181875 cites W2059303794 @default.
- W3182181875 cites W2072291715 @default.
- W3182181875 cites W2075751822 @default.
- W3182181875 cites W2079552505 @default.
- W3182181875 cites W2080299952 @default.
- W3182181875 cites W2087450488 @default.
- W3182181875 cites W2106662817 @default.
- W3182181875 cites W2112657827 @default.
- W3182181875 cites W2114348330 @default.
- W3182181875 cites W2132161976 @default.
- W3182181875 cites W2133226878 @default.
- W3182181875 cites W2139846563 @default.
- W3182181875 cites W2154298769 @default.
- W3182181875 cites W2159433999 @default.
- W3182181875 cites W2165448091 @default.
- W3182181875 cites W2188901027 @default.
- W3182181875 cites W2264372496 @default.
- W3182181875 cites W2275679820 @default.
- W3182181875 cites W2277194059 @default.
- W3182181875 cites W2346793215 @default.
- W3182181875 cites W2394530819 @default.
- W3182181875 cites W2413634893 @default.
- W3182181875 cites W2416901736 @default.
- W3182181875 cites W2438385881 @default.
- W3182181875 cites W2493930936 @default.
- W3182181875 cites W2518717287 @default.
- W3182181875 cites W2522336757 @default.
- W3182181875 cites W2546820174 @default.
- W3182181875 cites W2593598879 @default.
- W3182181875 cites W2600669583 @default.
- W3182181875 cites W2602572380 @default.
- W3182181875 cites W2608225419 @default.
- W3182181875 cites W2622634772 @default.
- W3182181875 cites W2734498030 @default.
- W3182181875 cites W2766034805 @default.
- W3182181875 cites W2788009939 @default.
- W3182181875 cites W2792125230 @default.
- W3182181875 cites W2793816106 @default.
- W3182181875 cites W2808464080 @default.
- W3182181875 cites W2810909862 @default.
- W3182181875 cites W2811416072 @default.
- W3182181875 cites W2883086294 @default.
- W3182181875 cites W2884705408 @default.
- W3182181875 cites W2885447533 @default.
- W3182181875 cites W2889857566 @default.
- W3182181875 cites W2893168313 @default.
- W3182181875 cites W2900124779 @default.
- W3182181875 cites W2905577463 @default.
- W3182181875 cites W2907017329 @default.
- W3182181875 cites W2917455007 @default.
- W3182181875 cites W2921074928 @default.
- W3182181875 cites W2938462293 @default.
- W3182181875 cites W2953774053 @default.
- W3182181875 cites W2967868928 @default.
- W3182181875 cites W2992823069 @default.
- W3182181875 cites W2997313349 @default.
- W3182181875 cites W2997775077 @default.
- W3182181875 cites W3004371339 @default.
- W3182181875 cites W3005100376 @default.
- W3182181875 cites W3027149287 @default.
- W3182181875 cites W3033201788 @default.
- W3182181875 cites W3042924866 @default.
- W3182181875 cites W3043722389 @default.
- W3182181875 cites W3045046608 @default.
- W3182181875 cites W3045966900 @default.
- W3182181875 cites W3080236435 @default.
- W3182181875 cites W3087924281 @default.
- W3182181875 cites W3094358252 @default.
- W3182181875 cites W3111255098 @default.
- W3182181875 cites W3114305588 @default.