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• W3182403886 abstract "MGA, a transcription factor and member of the MYC network, is mutated or deleted in a broad spectrum of malignancies. As a critical test of a tumor suppressive role, we inactivated Mga in two mouse models of non-small cell lung cancer using a CRISPR-based approach. MGA loss significantly accelerated tumor growth in both models and led to de-repression of non-canonical Polycomb ncPRC1.6 targets, including genes involved in metastasis and meiosis. Moreover, MGA deletion in human lung adenocarcinoma lines augmented invasive capabilities. We further show that MGA-MAX, E2F6, and L3MBTL2 co-occupy thousands of promoters and that MGA stabilizes these ncPRC1.6 subunits. Lastly, we report that MGA loss also induces a pro-growth effect in human colon organoids. Our studies establish MGA as a bona fide tumor suppressor in vivo and suggest a tumor suppressive mechanism in adenocarcinomas resulting from widespread transcriptional attenuation of MYC and E2F target genes mediated by MGA-MAX associated with a non-canonical Polycomb complex." @default.
• W3182403886 created "2021-07-19" @default.
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• W3182403886 date "2021-07-08" @default.
• W3182403886 modified "2023-09-29" @default.
• W3182403886 title "Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness" @default.
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• W3182403886 cites W2795073885 @default.
• W3182403886 cites W2883764945 @default.
• W3182403886 cites W2888423279 @default.
• W3182403886 cites W2899760200 @default.
• W3182403886 cites W2905640619 @default.
• W3182403886 cites W2921930449 @default.
• W3182403886 cites W2941917579 @default.
• W3182403886 cites W2942431730 @default.
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• W3182403886 doi "https://doi.org/10.7554/elife.64212" @default.
• W3182403886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8266391" @default.
• W3182403886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34236315" @default.
• W3182403886 hasPublicationYear "2021" @default.

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