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- W3182406641 endingPage "121018" @default.
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- W3182406641 abstract "Indoleamine 2,3-dioxygenase (IDO) as a principle enzyme in tryptophan (Trp) catabolism, modulates immune responses and promotes cancer progression. In recent decades, the newly emerging IDO inhibitors are regarded as the breakthrough for cancer immunotherapy. Intensified efforts have been increasingly made to, on the one hand, optimize the IDO inhibitors-based combination therapy in clinical trials; on the other hand, develop IDO inhibitors nanomedicines for tumor-targeted delivery in preclinical studies. This review will discuss the types of IDO inhibitors and the relevant clinical trials, especially those of the feasible combined therapeutic modalities. Moreover, it would be the first time to overview the cutting-edge nanomedicines that combine IDO inhibitors with other therapeutic modalities (e.g., chemotherapy, radiotherapy, photodynamic therapy (PDT), photothermal therapy (PTT) and immune checkpoint blockade) to effectively improve the effect of cancer therapy. Lastly, the prospects of IDO inhibitors in terms of clinical application and potential breakthroughs will be briefly discussed." @default.
- W3182406641 created "2021-07-19" @default.
- W3182406641 creator A5018073672 @default.
- W3182406641 creator A5024741363 @default.
- W3182406641 creator A5028349126 @default.
- W3182406641 creator A5035234824 @default.
- W3182406641 creator A5042792242 @default.
- W3182406641 creator A5044664499 @default.
- W3182406641 creator A5066567410 @default.
- W3182406641 date "2021-09-01" @default.
- W3182406641 modified "2023-10-13" @default.
- W3182406641 title "Indoleamine 2,3-dioxygenase (Ido) inhibitors and their nanomedicines for cancer immunotherapy" @default.
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