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- W3182408371 abstract "Membranous nephropathy (MN) is an organ-restricted autoimmune disease mainly caused by circulating autoantibodies against podocyte antigens, including the M-type phospholipase A2 receptor (PLA2R) and thrombospondin domain-containing 7A (THSD7A). Antibodies against PLA2R are present in 70%-80% and against THSD7A in 2% of adult patients, which provides a paradigm shift in molecular diagnosis and management monitoring. Both antigens share some similar characteristics: they are expressed by podocytes and have wide tissue distributions; they are bound by autoantibodies only under nonreducing conditions, and the subtype of most autoantibodies is IgG4. However, the factors triggering autoantibody production as well as the association among air pollution, malignancy, and the pathogenesis of MN remain unclear. In this review, we discuss the similarity between the pathological mechanisms triggered by disparate antigens and their associated diseases. Furthermore, we demonstrated the possibility that PM2.5, malignancy, and gene expression specifically induce exposure of these antigens through conformational changes, molecular mimicry, or increased expression eliciting autoimmune responses. Thus, this review provides novel insights into the pathological mechanism of MN." @default.
- W3182408371 created "2021-07-19" @default.
- W3182408371 creator A5000184677 @default.
- W3182408371 creator A5016556055 @default.
- W3182408371 creator A5029286129 @default.
- W3182408371 creator A5033150715 @default.
- W3182408371 creator A5059386427 @default.
- W3182408371 creator A5063746565 @default.
- W3182408371 creator A5079949674 @default.
- W3182408371 creator A5089157732 @default.
- W3182408371 date "2021-07-14" @default.
- W3182408371 modified "2023-10-15" @default.
- W3182408371 title "A Novel Insight into the Role of PLA2R and THSD7A in Membranous Nephropathy" @default.
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