FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182442569> ?p ?o ?g. }

• W3182442569 endingPage "139" @default.
• W3182442569 startingPage "131" @default.
• W3182442569 abstract "Allium sativum L. (garlic) has received a growing interest as both a food plant and folk remedy with promising antitumor and chemopreventive potential. So far, a large body of research has been conducted on garlic, mostly focusing on the bulbs, yet its roots remain unstudied and are discarded in considerable amounts as vegetable wastes. Accordingly, for the first time, this study examined the potential of A. sativum roots and their green synthesized silver nanoparticles (AgNPs) against hepatocellular carcinoma (HepG-2), breast cancer (Mcf-7), and colon cancer (Caco-2) cells lines. The formation of AgNPs was confirmed using a Transmission Electron Microscope (TEM), UV‒Visible spectroscopy, and Fourier-Transform Infrared Spectroscopy (FT-IR). Overall, the total ethanolic extract of A. sativum roots (TEEASR) significantly inhibited the growth of Caco-2, Mcf-7, and HepG-2 cells with IC50 values of 2.11 ± 0.03, 21.47 ± 0.15, and 45.12 ± 0.76 µg/mL, respectively, whereas AgNPs exhibited more prominent cytotoxic activity, which in the case of Caco-2 cells, was noticeably greater than doxorubicin (IC50= 0.47 ± 0.04 vs. 2.12 ± 0.04 µg/mL). Additionally, HPLC‒HESI‒HRMS analysis of TEEASR revealed the presence of a variety of metabolites with reported anticancer effects, largely dominated by organosulfur species. Interestingly, the characterized compounds showed moderate to promising binding interactions with the active site of human inositol phosphate multikinase (HIPMK), especially γ-glutamylphenylalanine (6) and allixin (7); highlighting their potential contribution to the notable cytotoxic properties of TEEASR as HIPMK inhibitors. These results might pave the way for the possible therapeutic and pharmaceutical applications of garlic by-products, including the roots, and their biogenic nanoparticles." @default.
• W3182442569 created "2021-07-19" @default.
• W3182442569 creator A5003601293 @default.
• W3182442569 creator A5007893610 @default.
• W3182442569 creator A5016755309 @default.
• W3182442569 creator A5035856756 @default.
• W3182442569 creator A5053985834 @default.
• W3182442569 creator A5054561716 @default.
• W3182442569 creator A5076058299 @default.
• W3182442569 creator A5076438240 @default.
• W3182442569 creator A5087100266 @default.
• W3182442569 date "2021-11-01" @default.
• W3182442569 modified "2023-10-07" @default.
• W3182442569 title "Cytotoxic potential of Allium sativum L. roots and their green synthesized nanoparticles supported with metabolomics and molecular docking analyses" @default.
• W3182442569 cites W1564578352 @default.
• W3182442569 cites W1566536699 @default.
• W3182442569 cites W1568891270 @default.
• W3182442569 cites W1845640203 @default.
• W3182442569 cites W1963541683 @default.
• W3182442569 cites W1968404863 @default.
• W3182442569 cites W1970858979 @default.
• W3182442569 cites W1971511412 @default.
• W3182442569 cites W1982605706 @default.
• W3182442569 cites W1991770236 @default.
• W3182442569 cites W2002801265 @default.
• W3182442569 cites W2023045586 @default.
• W3182442569 cites W2033069724 @default.
• W3182442569 cites W2046387695 @default.
• W3182442569 cites W2047469115 @default.
• W3182442569 cites W2047936455 @default.
• W3182442569 cites W2050529947 @default.
• W3182442569 cites W2051954596 @default.
• W3182442569 cites W2054621208 @default.
• W3182442569 cites W2054931962 @default.
• W3182442569 cites W2062586689 @default.
• W3182442569 cites W2071900033 @default.
• W3182442569 cites W2077491843 @default.
• W3182442569 cites W2078757278 @default.
• W3182442569 cites W2081340515 @default.
• W3182442569 cites W2089155556 @default.
• W3182442569 cites W2091741866 @default.
• W3182442569 cites W2104231958 @default.
• W3182442569 cites W2111934933 @default.
• W3182442569 cites W2114918609 @default.
• W3182442569 cites W2121318534 @default.
• W3182442569 cites W2128166349 @default.
• W3182442569 cites W2135890502 @default.
• W3182442569 cites W2144095756 @default.
• W3182442569 cites W2144495794 @default.
• W3182442569 cites W2162760085 @default.
• W3182442569 cites W2184794753 @default.
• W3182442569 cites W2221837786 @default.
• W3182442569 cites W2273992128 @default.
• W3182442569 cites W2467170939 @default.
• W3182442569 cites W2562413929 @default.
• W3182442569 cites W2625340940 @default.
• W3182442569 cites W2725582745 @default.
• W3182442569 cites W2734399791 @default.
• W3182442569 cites W2753593237 @default.
• W3182442569 cites W2753774547 @default.
• W3182442569 cites W2809820748 @default.
• W3182442569 cites W2883774964 @default.
• W3182442569 cites W2895473832 @default.
• W3182442569 cites W2896532887 @default.
• W3182442569 cites W2901975034 @default.
• W3182442569 cites W2927578120 @default.
• W3182442569 cites W2951902079 @default.
• W3182442569 cites W2955644861 @default.
• W3182442569 cites W2957657727 @default.
• W3182442569 cites W2958019033 @default.
• W3182442569 cites W2985648358 @default.
• W3182442569 cites W2993019081 @default.
• W3182442569 cites W2997649643 @default.
• W3182442569 cites W2999417355 @default.
• W3182442569 cites W3013025666 @default.
• W3182442569 cites W3041801186 @default.
• W3182442569 cites W3043866042 @default.
• W3182442569 cites W3124040543 @default.
• W3182442569 cites W4229692339 @default.
• W3182442569 doi "https://doi.org/10.1016/j.sajb.2021.06.020" @default.
• W3182442569 hasPublicationYear "2021" @default.
• W3182442569 type Work @default.
• W3182442569 sameAs 3182442569 @default.
• W3182442569 citedByCount "11" @default.
• W3182442569 countsByYear W31824425692022 @default.
• W3182442569 countsByYear W31824425692023 @default.
• W3182442569 crossrefType "journal-article" @default.
• W3182442569 hasAuthorship W3182442569A5003601293 @default.
• W3182442569 hasAuthorship W3182442569A5007893610 @default.
• W3182442569 hasAuthorship W3182442569A5016755309 @default.
• W3182442569 hasAuthorship W3182442569A5035856756 @default.
• W3182442569 hasAuthorship W3182442569A5053985834 @default.
• W3182442569 hasAuthorship W3182442569A5054561716 @default.
• W3182442569 hasAuthorship W3182442569A5076058299 @default.
• W3182442569 hasAuthorship W3182442569A5076438240 @default.
• W3182442569 hasAuthorship W3182442569A5087100266 @default.
• W3182442569 hasConcept C154317977 @default.
• W3182442569 hasConcept C178790620 @default.

• next