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• W3182656683 abstract "The prefrontal cortex (PFC) governs top–down control of attention and is known to be vulnerable in aging. Cortical reorganization with increased PFC recruitment is suggested to account for functional compensation. Here, we hypothesized that reduced PFC output would exert differential effects on attentional capacities in young and aged rats, with the latter exhibiting a more robust decline in performance. A chemogenetic approach involving designer receptors exclusively activated by designer drugs was utilized to determine the impact of silencing PFC projection neurons in rats performing an operant attention task. Visual distractors were presented in all behavioral testing sessions to tax attentional resources. Under control conditions, aged rats exhibited impairments in discriminating signals with the shortest duration from non-signal events. Surprisingly, chemogenetic inhibition of PFC output neurons did not worsen performance amongst aged animals. Conversely, significant impairments in attentional capacities were observed in young subjects following such manipulation. Given the involvement of PFC-projecting basal forebrain cholinergic neurons in top–down regulation of attention, amperometric recordings were conducted to measure alterations in prefrontal cholinergic transmission in a separate cohort of young and aged rats. While PFC silencing resulted in a robust attenuation of tonic cholinergic signaling across age groups, the capacity to generate phasic cholinergic transients was impaired only amongst young animals. Collectively, our findings suggest a reduced efficiency of PFC-mediated top–down control of attention and cholinergic system in aging, and that activity of PFC output neurons does not reflect compensation in aged rats, at least in the attention domain." @default.
• W3182656683 created "2021-07-19" @default.
• W3182656683 creator A5001213022 @default.
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• W3182656683 creator A5048480572 @default.
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• W3182656683 date "2021-07-10" @default.
• W3182656683 modified "2023-09-24" @default.
• W3182656683 title "Chemogenetic inhibition of prefrontal projection neurons constrains top–down control of attention in young but not aged rats" @default.
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• W3182656683 doi "https://doi.org/10.1007/s00429-021-02336-2" @default.
• W3182656683 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8355172" @default.
• W3182656683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34247267" @default.

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