Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182659576> ?p ?o ?g. }
- W3182659576 endingPage "107933" @default.
- W3182659576 startingPage "107933" @default.
- W3182659576 abstract "T cell immunoglobulin and mucin domain 3 (TIM-3) was originally found to be expressed on the surface of Th1 cells, acting as a negative regulator and binding to the ligand galectin-9 to mediate Th1 cell the apoptosis. Recent studies have shown that TIM-3 is also expressed on other immune cells, such as macrophages, dendritic cells, and monocytes. In addition, TIM-3 ligands also include Psdter, High Mobility Group Box 1 (HMGB1) and Carcinoembryonic antigen associated cell adhesion molecules (Ceacam-1), which have different effects upon biding to different ligands on immune cells. Studies have shown that TIM-3 plays an important role in autoimmune diseases, chronic viral infections and tumors. A large amount of experimental data supports TIM-3 as an immune checkpoint, and targeting TIM-3 is a promising treatment method in current immunotherapy, especially the new combination of other immune checkpoint blockers. In this review, we summarize the role of TIM-3 in different diseases and its possible signaling pathway mechanisms, providing new insights for better breakthrough immunotherapy." @default.
- W3182659576 created "2021-07-19" @default.
- W3182659576 creator A5015521724 @default.
- W3182659576 creator A5048718343 @default.
- W3182659576 creator A5080256378 @default.
- W3182659576 creator A5088345733 @default.
- W3182659576 creator A5090492498 @default.
- W3182659576 date "2021-10-01" @default.
- W3182659576 modified "2023-10-16" @default.
- W3182659576 title "TIM-3: An update on immunotherapy" @default.
- W3182659576 cites W1519297113 @default.
- W3182659576 cites W1543067125 @default.
- W3182659576 cites W1585589080 @default.
- W3182659576 cites W1593046582 @default.
- W3182659576 cites W1856206988 @default.
- W3182659576 cites W1936170382 @default.
- W3182659576 cites W1937813437 @default.
- W3182659576 cites W1962920088 @default.
- W3182659576 cites W1969925688 @default.
- W3182659576 cites W1971425687 @default.
- W3182659576 cites W1972839746 @default.
- W3182659576 cites W1976105607 @default.
- W3182659576 cites W1981674995 @default.
- W3182659576 cites W1985117788 @default.
- W3182659576 cites W1991807494 @default.
- W3182659576 cites W1993528700 @default.
- W3182659576 cites W1996032846 @default.
- W3182659576 cites W1996890691 @default.
- W3182659576 cites W1997731331 @default.
- W3182659576 cites W1998286441 @default.
- W3182659576 cites W1998618704 @default.
- W3182659576 cites W1999700641 @default.
- W3182659576 cites W2007610160 @default.
- W3182659576 cites W2008914281 @default.
- W3182659576 cites W2010212241 @default.
- W3182659576 cites W2013177587 @default.
- W3182659576 cites W2031627869 @default.
- W3182659576 cites W2033309446 @default.
- W3182659576 cites W2036574174 @default.
- W3182659576 cites W2037393136 @default.
- W3182659576 cites W2048542646 @default.
- W3182659576 cites W2055819944 @default.
- W3182659576 cites W2056211666 @default.
- W3182659576 cites W2068047393 @default.
- W3182659576 cites W2070631889 @default.
- W3182659576 cites W2071638842 @default.
- W3182659576 cites W2091493364 @default.
- W3182659576 cites W2097995306 @default.
- W3182659576 cites W2101581360 @default.
- W3182659576 cites W2103950437 @default.
- W3182659576 cites W2107598346 @default.
- W3182659576 cites W2107777135 @default.
- W3182659576 cites W2112400160 @default.
- W3182659576 cites W2113649995 @default.
- W3182659576 cites W2113787335 @default.
- W3182659576 cites W2114238926 @default.
- W3182659576 cites W2114688998 @default.
- W3182659576 cites W2117156688 @default.
- W3182659576 cites W2122730216 @default.
- W3182659576 cites W2123363005 @default.
- W3182659576 cites W2125616358 @default.
- W3182659576 cites W2126259300 @default.
- W3182659576 cites W2128758225 @default.
- W3182659576 cites W2134644618 @default.
- W3182659576 cites W2135744728 @default.
- W3182659576 cites W2136546379 @default.
- W3182659576 cites W2142015379 @default.
- W3182659576 cites W2145476394 @default.
- W3182659576 cites W2151293773 @default.
- W3182659576 cites W2160834915 @default.
- W3182659576 cites W2163385161 @default.
- W3182659576 cites W2167048802 @default.
- W3182659576 cites W2167717479 @default.
- W3182659576 cites W2167939758 @default.
- W3182659576 cites W2168231169 @default.
- W3182659576 cites W2172223853 @default.
- W3182659576 cites W2299170905 @default.
- W3182659576 cites W2329173260 @default.
- W3182659576 cites W2337496778 @default.
- W3182659576 cites W2403400382 @default.
- W3182659576 cites W2564210377 @default.
- W3182659576 cites W2593059553 @default.
- W3182659576 cites W2596120176 @default.
- W3182659576 cites W2758753873 @default.
- W3182659576 cites W2811036051 @default.
- W3182659576 cites W2971886417 @default.
- W3182659576 cites W3010585909 @default.
- W3182659576 cites W3012422862 @default.
- W3182659576 cites W3014670641 @default.
- W3182659576 cites W3043396196 @default.
- W3182659576 cites W3106878515 @default.
- W3182659576 cites W3112281175 @default.
- W3182659576 cites W3128803455 @default.
- W3182659576 cites W3133854897 @default.
- W3182659576 doi "https://doi.org/10.1016/j.intimp.2021.107933" @default.
- W3182659576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34224993" @default.
- W3182659576 hasPublicationYear "2021" @default.
- W3182659576 type Work @default.