Matches in SemOpenAlex for { <https://semopenalex.org/work/W3182695211> ?p ?o ?g. }
- W3182695211 endingPage "138" @default.
- W3182695211 startingPage "115" @default.
- W3182695211 abstract "Currently, there are two safe and effective therapeutic strategies for chronic hepatitis B treatment, namely, nucleoside analogs and interferon alpha (pegylated or non-pegylated). These treatments can control viral replication and improve survival; however, they do not eliminate the virus and therefore require long-term continued therapy. In addition, there are significant concerns about virus rebound on discontinuation of therapy and the development of fibrosis and hepatocellular carcinoma despite therapy. Therefore, the search for new, more effective, and safer antiviral agents that can cure hepatitis B virus (HBV) continues. Anti-HBV drug discovery and development is fundamentally impacted by our current understanding of HBV replication, disease physiopathology, and persistence of HBV covalently closed circular DNA (cccDNA). Several HBV replication targets are the basis for novel anti-HBV drug development strategies. Many of them are already in clinical trial phase 1 or 2, while others with promising results are still in preclinical stages. As research intensifies, potential HBV curative therapies and modalities in the pipeline are now on the horizon." @default.
- W3182695211 created "2021-07-19" @default.
- W3182695211 creator A5006954915 @default.
- W3182695211 creator A5051240459 @default.
- W3182695211 creator A5087052821 @default.
- W3182695211 date "2021-01-01" @default.
- W3182695211 modified "2023-10-18" @default.
- W3182695211 title "Moving Fast Toward Hepatitis B Virus Elimination" @default.
- W3182695211 cites W1481774199 @default.
- W3182695211 cites W1500588094 @default.
- W3182695211 cites W1699150062 @default.
- W3182695211 cites W1844576826 @default.
- W3182695211 cites W1965075846 @default.
- W3182695211 cites W1972613143 @default.
- W3182695211 cites W1996221409 @default.
- W3182695211 cites W2006859864 @default.
- W3182695211 cites W2037402545 @default.
- W3182695211 cites W2043795685 @default.
- W3182695211 cites W2051173965 @default.
- W3182695211 cites W2061543400 @default.
- W3182695211 cites W2088474579 @default.
- W3182695211 cites W2094798000 @default.
- W3182695211 cites W2101032357 @default.
- W3182695211 cites W2107788106 @default.
- W3182695211 cites W2117991391 @default.
- W3182695211 cites W2120426460 @default.
- W3182695211 cites W2143103275 @default.
- W3182695211 cites W2305221193 @default.
- W3182695211 cites W2340384276 @default.
- W3182695211 cites W2415863453 @default.
- W3182695211 cites W2418554548 @default.
- W3182695211 cites W2462974575 @default.
- W3182695211 cites W2567060352 @default.
- W3182695211 cites W2567845659 @default.
- W3182695211 cites W2588981046 @default.
- W3182695211 cites W2605785536 @default.
- W3182695211 cites W2610009131 @default.
- W3182695211 cites W2625448726 @default.
- W3182695211 cites W2632757169 @default.
- W3182695211 cites W2734412053 @default.
- W3182695211 cites W2756572280 @default.
- W3182695211 cites W2765449392 @default.
- W3182695211 cites W2767728893 @default.
- W3182695211 cites W2767987272 @default.
- W3182695211 cites W2790373237 @default.
- W3182695211 cites W2793070915 @default.
- W3182695211 cites W2793638189 @default.
- W3182695211 cites W2800070529 @default.
- W3182695211 cites W2801421343 @default.
- W3182695211 cites W2803007778 @default.
- W3182695211 cites W2808018867 @default.
- W3182695211 cites W2887512747 @default.
- W3182695211 cites W2888170974 @default.
- W3182695211 cites W2889911303 @default.
- W3182695211 cites W2890260657 @default.
- W3182695211 cites W2912166467 @default.
- W3182695211 cites W2920438880 @default.
- W3182695211 cites W2922294623 @default.
- W3182695211 cites W2926965960 @default.
- W3182695211 cites W2935781022 @default.
- W3182695211 cites W2937373050 @default.
- W3182695211 cites W2937670169 @default.
- W3182695211 cites W2937842982 @default.
- W3182695211 cites W2937904419 @default.
- W3182695211 cites W2938431202 @default.
- W3182695211 cites W2938610700 @default.
- W3182695211 cites W2938947867 @default.
- W3182695211 cites W2945552842 @default.
- W3182695211 cites W2946917567 @default.
- W3182695211 cites W2948741448 @default.
- W3182695211 cites W2951604497 @default.
- W3182695211 cites W2965094856 @default.
- W3182695211 cites W2965488988 @default.
- W3182695211 cites W2972942466 @default.
- W3182695211 cites W2980699734 @default.
- W3182695211 cites W2981353644 @default.
- W3182695211 cites W2984221112 @default.
- W3182695211 cites W2986454336 @default.
- W3182695211 cites W2988352662 @default.
- W3182695211 cites W2988788411 @default.
- W3182695211 cites W2994578573 @default.
- W3182695211 cites W2994967047 @default.
- W3182695211 cites W3000169502 @default.
- W3182695211 cites W3008448491 @default.
- W3182695211 cites W3009378833 @default.
- W3182695211 cites W3010824469 @default.
- W3182695211 cites W3010832552 @default.
- W3182695211 cites W3011016130 @default.
- W3182695211 cites W3011632156 @default.
- W3182695211 cites W3013218605 @default.
- W3182695211 cites W3014302917 @default.
- W3182695211 cites W3014968572 @default.
- W3182695211 cites W3022210946 @default.
- W3182695211 cites W3025914846 @default.
- W3182695211 cites W3029052314 @default.
- W3182695211 cites W3035585198 @default.
- W3182695211 cites W3037965449 @default.
- W3182695211 cites W3084357673 @default.