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- W3182732366 abstract "Abstract Background & Aims : Coronavirus-19 (COVID-19) due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) is an ongoing global pandemic causing more than three million deaths. Protease inhibitors had been shown to decrease viral entry. However, the role of dabigatran, an inhibitor of multiple proteases, on coronavirus remains unknown. Methods: MRC-5 cells, HCT-8, or Huh-7 cells were infected with Beta-coronavirus OC43 and SARS-CoV-2. Cytopathic effects (CPE) were monitored by imaging. Viral load was measured by quantitative RT-PCR. Viral protein was detected by Western blot. Results : Camostat, a serine protease inhibitor, had no effect on the replication of OC43 and SARS CoV-2 even at higher doses. Dabigatran inhibited replication, viral entry and CPE of OC43 in a dose-dependent manner. Dabigatran and Remdisivir synergistically inhibited OC43 virus replication. Conclusions : Dabigatran may be beneficial in treating SARS-CoV-2 both for anticoagulation and viral replication inhibition need to be evaluated further." @default.
- W3182732366 created "2021-07-19" @default.
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- W3182732366 date "2021-07-07" @default.
- W3182732366 modified "2023-09-27" @default.
- W3182732366 title "Dabigatran and Remdesivir Synergistically Inhibit Coronavirus Replication" @default.
- W3182732366 doi "https://doi.org/10.21203/rs.3.rs-600798/v1" @default.
- W3182732366 hasPublicationYear "2021" @default.
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