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• W3183099221 abstract "Our research measures the essential oil analysis mineral substance profiles, total phenolic substance content, free radical scavenger properties, antioxidant capacity, and enzyme inhibitory activity of Sideritis akmanii Aytaç, Ekici & Dönmez, 1996.A mixture of S. akmanii plant roots and stems were used. Essential fatty acid components of S. akmanii were determined by gas chromatography-mass spectrometry and bioelement concentrations by inductively coupled plasma optical emission spectrometry. The antioxidant activity of extracts was screened by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities, total phenolic content, total antioxidant status (TAS), total oxidant status (TOS) analysis. Cholinesterase (ChE), α-glucosidase, α-amylase, and tyrosinase inhibitory activity was determined.The results demonstrated that the phenolic substance content was higher in methanol extract (144.08±2.01 μg gallic acid equivalent/mg extract). DPPH scavenging effect of S. akmanii methanol extract (73.2%) was higher than acetone extract (60.1%). TAS values of extract methanol and acetone were 2.32±0.4 and 2.38±0.2 μmol trolox Eq /g, TOS values were 4.88±0.6 and 5.04±0.5 μmol H2O2 Eq/g, and oxidative stress index values were 2.1±0.3 and 2.11±0.24 arbitrary units, respectively. Hexadecanoic acid (17.9%) was found as the main component in the plant essential oil. S. akmanii species was prominent with high Mg and Al concentrations. Anti-ChE activity was determined that acetone extract (42.95%±0.90; 217.37±0.81 mg galantamine equivalents [(GALAEs)/g] exhibited higher than methanol (33.33%±1.81; 208.76±1.62 mg GALAE/g). α-Amylase inhibition was high in methanol extract [53.62±1.85 mmol angiotensin converting enzymes (ACEs)/g extract] compared to acetone (47.73±0.92 mmol ACEs/g extract). The tyrosinase inhibitory activity of S. akmanii was determined very low inhibition of the reference compound.It has been determined that S. akmanii Aytaç, Ekici & Dönmez extracts have antioxidant properties and can inhibit acetylcholinesterase, α-glucosidase, α-amylase enzymes. This study is informative on future studies on S. akmanii a highly bioavailable species and very extensive studies should be carried out." @default.
• W3183099221 created "2021-07-19" @default.
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• W3183099221 date "2022-02-25" @default.
• W3183099221 modified "2023-09-28" @default.
• W3183099221 title "Essential Oil Content, Antioxidative Characteristics and Enzyme Inhibitory Activity of <i>Sideritis akmanii</i> Aytaç, Ekici & Dönmez" @default.
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• W3183099221 doi "https://doi.org/10.4274/tjps.galenos.2021.86422" @default.
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