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- W3183131010 endingPage "109574" @default.
- W3183131010 startingPage "109574" @default.
- W3183131010 abstract "NAD(P)H: Quinone Oxidoreductase 1 (NQO1) is an antioxidant enzyme that catalyzes the two-electron reduction of several different classes of quinone-like compounds (quinones, quinone imines, nitroaromatics, and azo dyes). One-electron reduction of quinone or quinone-like metabolites is considered to generate semiquinones to initiate redox cycling that is responsible for the generation of reactive oxygen species and oxidative stress and may contribute to the initiation of adverse drug reactions and adverse health effects. On the other hand, the two-electron reduction of quinoid compounds appears important for drug activation (bioreductive activation) via chemical rearrangement or autoxidation. Two-electron reduction decreases quinone levels and opportunities for the generation of reactive species that can deplete intracellular thiol pools. Also, studies have shown that induction or depletion (knockout) of NQO1 were associated with decreased or increased susceptibilities to oxidative stress, respectively. Moreover, another member of the quinone reductase family, NRH: Quinone Oxidoreductase 2 (NQO2), has a significant functional and structural similarity with NQO1. The activity of both antioxidant enzymes, NQO1 and NQO2, becomes critically important when other detoxification pathways are exhausted. Therefore, this article summarizes the interactions of NQO1 and NQO2 with different pharmacological agents, endogenous biochemicals, and environmental contaminants that would be useful in the development of therapeutic approaches to reduce the adverse drug reactions as well as protection against quinone-induced oxidative damage. Also, future directions and areas of further study for NQO1 and NQO2 are discussed." @default.
- W3183131010 created "2021-07-19" @default.
- W3183131010 creator A5028928208 @default.
- W3183131010 creator A5029718905 @default.
- W3183131010 creator A5058904298 @default.
- W3183131010 date "2021-08-01" @default.
- W3183131010 modified "2023-10-12" @default.
- W3183131010 title "Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants" @default.
- W3183131010 cites W112949929 @default.
- W3183131010 cites W1417333514 @default.
- W3183131010 cites W1489452981 @default.
- W3183131010 cites W1514135333 @default.
- W3183131010 cites W1523565294 @default.
- W3183131010 cites W1537365266 @default.
- W3183131010 cites W1544674423 @default.
- W3183131010 cites W1583228069 @default.
- W3183131010 cites W1604748982 @default.
- W3183131010 cites W1683600212 @default.
- W3183131010 cites W173455673 @default.
- W3183131010 cites W1781217464 @default.
- W3183131010 cites W1822834486 @default.
- W3183131010 cites W1903041271 @default.
- W3183131010 cites W1925723678 @default.
- W3183131010 cites W1964851962 @default.
- W3183131010 cites W1966586194 @default.
- W3183131010 cites W1967684747 @default.
- W3183131010 cites W1968101365 @default.
- W3183131010 cites W1970060837 @default.
- W3183131010 cites W1971179661 @default.
- W3183131010 cites W1972065523 @default.
- W3183131010 cites W1973118156 @default.
- W3183131010 cites W1974741013 @default.
- W3183131010 cites W1977390940 @default.
- W3183131010 cites W1978153568 @default.
- W3183131010 cites W1979013339 @default.
- W3183131010 cites W1979092710 @default.
- W3183131010 cites W1979578283 @default.
- W3183131010 cites W1980490891 @default.
- W3183131010 cites W1981224192 @default.
- W3183131010 cites W1981740916 @default.
- W3183131010 cites W1982805396 @default.
- W3183131010 cites W1985368964 @default.
- W3183131010 cites W1986805238 @default.
- W3183131010 cites W1986851225 @default.
- W3183131010 cites W1989991152 @default.
- W3183131010 cites W1990283519 @default.
- W3183131010 cites W1990927292 @default.
- W3183131010 cites W1991259149 @default.
- W3183131010 cites W1991681755 @default.
- W3183131010 cites W1992346119 @default.
- W3183131010 cites W1995367007 @default.
- W3183131010 cites W1995474710 @default.
- W3183131010 cites W1996531619 @default.
- W3183131010 cites W1997346441 @default.
- W3183131010 cites W1998871018 @default.
- W3183131010 cites W1999228082 @default.
- W3183131010 cites W1999986726 @default.
- W3183131010 cites W2000474839 @default.
- W3183131010 cites W2002053509 @default.
- W3183131010 cites W2003891537 @default.
- W3183131010 cites W2003894821 @default.
- W3183131010 cites W2004856155 @default.
- W3183131010 cites W2008158988 @default.
- W3183131010 cites W2008258984 @default.
- W3183131010 cites W2009080781 @default.
- W3183131010 cites W2009593507 @default.
- W3183131010 cites W2010128263 @default.
- W3183131010 cites W2011638807 @default.
- W3183131010 cites W2013024999 @default.
- W3183131010 cites W2013656214 @default.
- W3183131010 cites W2015055507 @default.
- W3183131010 cites W2015957376 @default.
- W3183131010 cites W2016228585 @default.
- W3183131010 cites W2016804918 @default.
- W3183131010 cites W2017319763 @default.
- W3183131010 cites W2019179222 @default.
- W3183131010 cites W2019190381 @default.
- W3183131010 cites W2021236142 @default.
- W3183131010 cites W2021923729 @default.
- W3183131010 cites W2022582116 @default.
- W3183131010 cites W2023062971 @default.
- W3183131010 cites W2024603645 @default.
- W3183131010 cites W2025250967 @default.
- W3183131010 cites W2025396651 @default.
- W3183131010 cites W2026109950 @default.
- W3183131010 cites W2026317368 @default.
- W3183131010 cites W2026531109 @default.
- W3183131010 cites W2028965527 @default.
- W3183131010 cites W2029063576 @default.
- W3183131010 cites W2029587579 @default.
- W3183131010 cites W2029591534 @default.
- W3183131010 cites W2031091418 @default.
- W3183131010 cites W2034173353 @default.
- W3183131010 cites W2034584551 @default.
- W3183131010 cites W2034665339 @default.
- W3183131010 cites W2035475671 @default.
- W3183131010 cites W2045393285 @default.
- W3183131010 cites W2045516863 @default.