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• W3183136870 abstract "Identify the effect of ultrathin drug eluting stents on long term outcomes in coronary artery disease.Although second-generation drug eluting stents (DES) are superior to first-generation DES, persistence of adverse outcomes has led to continued refinement in design. Ultrathin second-generation DES have been shown to improve outcomes at 1-year follow-up. Beyond 1-year their effect remains unknown.PubMed, Embase and Cochrane Database were searched for randomized controlled trials that compared ultrathin (defined as <70 um) to standard thickness second-generation DES. Studies were chosen according to the PROSPERO protocol (CRD42020185374). Data from randomized controlled trials were pooled using random-effects model (Mantel-Haenszel). The primary outcome was target lesion failure (TLF) at 2 years, a composite of cardiac death, target vessel myocardial infarction, and ischemia-driven target vessel revascularization. Secondary outcomes included TLF at 3 and 5 years, the components of TLF and definite or probable stent thrombosis. Differences in outcomes between groups were presented in Forest plots as risk ratios (RR) with corresponding 95% confidence intervals (CIs) for each trial.We identified 18 publications from 10 trials with14,649 patients. At 2-years there was a significant 12% reduction in TLF (RR, 0.88; 95% CI 0.78-0.99; p < 0.05) associated with the use of ultrathin DES. At 3-years, there was a significant 19% reduction in TLF with ultrathin DES (RR, 0.79; 95% CI 0.64-0.98; p < 0.05).In patients undergoing percutaneous coronary intervention, ultrathin DES improve long term clinical outcomes." @default.
• W3183136870 created "2021-07-19" @default.
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• W3183136870 date "2021-07-08" @default.
• W3183136870 modified "2023-10-16" @default.
• W3183136870 title "Long term outcomes of ultrathin versus standard thickness <scp>second‐generation</scp> drug eluting stents: <scp>Meta‐analysis</scp> of randomized trials" @default.
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• W3183136870 doi "https://doi.org/10.1002/ccd.29866" @default.
• W3183136870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34236755" @default.
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