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- W3183161080 abstract "Abstract SARS-CoV-2 spike mRNA vaccines 1–3 mediate protection from severe disease as early as ten days after prime vaccination 3 , when neutralizing antibodies are hardly detectable 4–6 . Vaccine-induced CD8 + T cells may therefore be the main mediators of protection at this early stage 7,8 . The details of their induction, comparison to natural infection, and association with other arms of vaccine-induced immunity remain, however, incompletely understood. Here we show on a single-epitope level that a stable and fully functional CD8 + T cell response is vigorously mobilized one week after prime vaccination with bnt162b2, when circulating CD4 + T cells and neutralizing antibodies are still weakly detectable. Boost vaccination induced a robust expansion that generated highly differentiated effector CD8 + T cells; however, neither the functional capacity nor the memory precursor T cell pool was affected. Compared with natural infection, vaccine-induced early memory T cells exhibited similar functional capacities but a different subset distribution. Our results indicate that CD8 + T cells are important effector cells, are expanded in the early protection window after prime vaccination, precede maturation of other effector arms of vaccine-induced immunity and are stably maintained after boost vaccination." @default.
- W3183161080 created "2021-08-02" @default.
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- W3183161080 date "2021-07-28" @default.
- W3183161080 modified "2023-10-17" @default.
- W3183161080 title "Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine" @default.
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- W3183161080 doi "https://doi.org/10.1038/s41586-021-03841-4" @default.
- W3183161080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8426185" @default.
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